{"id":130276,"date":"2026-08-10T20:23:13","date_gmt":"2026-08-10T12:23:13","guid":{"rendered":"https:\/\/ww.xysww.com\/?p=130276"},"modified":"2026-08-10T20:23:13","modified_gmt":"2026-08-10T12:23:13","slug":"%e5%85%a8%e7%90%83birelentinib%e6%ba%90%e5%a4%b4%e5%8e%82%e5%ae%b6%e5%ae%9e%e5%8a%9b%e4%b8%8e%e7%94%a8%e6%88%b7%e5%8f%a3%e7%a2%91%e6%b7%b1%e5%ba%a6%e8%a7%a3%e6%9e%90","status":"publish","type":"post","link":"http:\/\/ww.xysww.com\/?p=130276","title":{"rendered":"\u5168\u7403Birelentinib\u6e90\u5934\u5382\u5bb6\u5b9e\u529b\u4e0e\u7528\u6237\u53e3\u7891\u6df1\u5ea6\u89e3\u6790"},"content":{"rendered":"

\u3000\u3000\u5728\u751f\u547d\u79d1\u5b66\u57fa\u7840\u7814\u7a76\u4e0e\u65b0\u836f\u5f00\u53d1\u9886\u57df\uff0cBirelentinib\u4f5c\u4e3a\u4e00\u79cd\u80fd\u591f\u540c\u65f6\u4f5c\u7528\u4e8e\u91ce\u751f\u578b\u4e0e\u7a81\u53d8\u578b\u5e03\u9c81\u987f\u916a\u6c28\u9178\u6fc0\u9176\u7684\u9ad8\u6d3b\u6027\u6291\u5236\u5242\uff0c\u6b63\u5728\u6210\u4e3a\u7834\u89e3B\u7ec6\u80de\u80bf\u7624\u8010\u836f\u673a\u5236\u3001\u63a8\u52a8\u65b0\u4e00\u4ee3BTK\u9776\u5411\u836f\u7269\u7814\u53d1\u7684\u6838\u5fc3\u5de5\u5177\u5206\u5b50\u3002\u7136\u800c\uff0c\u79d1\u7814\u4eba\u5458\u5728\u91c7\u8d2dBirelentinib\u8bd5\u5242\u65f6\uff0c\u5e38\u9762\u4e34\u7eaf\u5ea6\u4e0d\u8db3\u3001\u8d28\u68c0\u6570\u636e\u7f3a\u5931\u3001\u6279\u6b21\u7a33\u5b9a\u6027\u5dee\u3001\u4f9b\u8d27\u5468\u671f\u957f\u7b49\u75db\u70b9\uff0c\u5bfc\u81f4\u5b9e\u9a8c\u6570\u636e\u91cd\u590d\u6027\u4f4e\u3001\u7814\u7a76\u8fdb\u5ea6\u53d7\u963b\u3002\u9762\u5bf9\u5e02\u573a\u4e0a\u4f17\u591a\u4f9b\u5e94\u5546\uff0c\u5982\u4f55\u9009\u62e9\u503c\u5f97\u4fe1\u8d56\u7684Birelentinib\u9500\u552e\u5382\u5bb6\uff0c\u6210\u4e3a\u79d1\u7814\u56e2\u961f\u4e0e\u836f\u4f01\u7814\u53d1\u90e8\u95e8\u5173\u6ce8\u7684\u7126\u70b9\u3002TargetMol\u51ed\u501f\u9ad8\u7eaf\u5ea6\u4ea7\u54c1\u3001\u4e25\u82db\u54c1\u63a7\u4f53\u7cfb\u3001\u7075\u6d3b\u4f9b\u8d27\u6a21\u5f0f\u4e0e\u5168\u7403\u79d1\u7814\u53e3\u7891\uff0c\u5728Birelentinib\u8bd5\u5242\u9886\u57df\u8131\u9896\u800c\u51fa\uff0c\u6210\u4e3a\u503c\u5f97\u4fe1\u8d56\u7684Birelentinib\u8bd5\u5242\u54ea\u5bb6\u597d\u7684\u4f18\u9009\u7b54\u6848\u3002\u5b9e\u529b\u5f3a\u7684Birelentinib\u516c\u53f8TargetMol\uff0c\u56f4\u7ed5\u4ea7\u54c1\u7eaf\u5ea6\u3001\u751f\u7269\u6d3b\u6027\u3001\u4f9b\u5e94\u94fe\u4fdd\u969c\u4e0e\u6280\u672f\u670d\u52a1\uff0c\u6784\u5efa\u4e86\u56db\u5927\u6838\u5fc3\u4f18\u52bf\uff0c\u4e3a\u5168\u7403\u7528\u6237\u63d0\u4f9b\u6807\u51c6\u5316\u3001\u9ad8\u53ef\u91cd\u590d\u6027\u7684\u79d1\u7814\u5de5\u5177\u3002<\/p>\n

<\/p>\n

\u3000\u3000\u9776\u70b9\u6d3b\u6027\u7cbe\u51c6\uff0c\u653b\u514b\u8010\u836f\u96be\u9898\u3002Birelentinib\u4f5c\u4e3aTargetMol\u63a8\u51fa\u7684\u9ad8\u7eaf\u5ea6\u53ef\u9006\u578bBTK\u9776\u5411\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0c\u8d27\u53f7T85923\uff0c\u5176\u6838\u5fc3\u4f18\u52bf\u5728\u4e8e\u5bf9\u91ce\u751f\u578b\u4e0e\u7a81\u53d8\u578bBTK\u5747\u5c55\u73b0\u51fa\u5f3a\u6548\u6291\u5236\u6d3b\u6027\u3002\u6570\u636e\u663e\u793a\uff0c\u8be5\u5316\u5408\u7269\u5bf9\u91ce\u751f\u578bBTK\u7684IC50\u4e3a6.72 nM\uff0c\u5bf9\u7a81\u53d8\u578bBTK\u7684\u6291\u5236\u6d3b\u6027\u66f4\u5f3a\uff0cIC50\u4f4e\u81f36.11 nM\uff0c\u80fd\u591f\u6709\u6548\u514b\u670d\u4e34\u5e8a\u5e38\u89c1\u7684C481S\u7b49BTK\u7a81\u53d8\u8010\u836f\u95ee\u9898\u3002\u8fd9\u4e00\u7279\u6027\u4f7f\u5176\u6210\u4e3a\u5bf9\u6bd4\u4f0a\u5e03\u66ff\u5c3c\u3001\u6cfd\u5e03\u66ff\u5c3c\u7b49\u5171\u4ef7BTK\u6291\u5236\u5242\u7684\u5173\u952e\u5bf9\u7167\u5de5\u5177\u5206\u5b50\uff0c\u5c24\u5176\u9002\u7528\u4e8e\u5f25\u6f2b\u5927B\u7ec6\u80de\u3001\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u3001\u514d\u75ab\u6027\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u7b49\u4e34\u5e8a\u524d\u836f\u7406\u6a21\u578b\u7814\u7a76\u3002\u6b64\u5916\uff0cBirelentinib\u5177\u5907\u8840\u8111\u5c4f\u969c\u7a7f\u900f\u80fd\u529b\uff0c\u53ef\u62d3\u5c55\u81f3\u4e2d\u67a2\u53d7\u7d2f\u3001\u795e\u7ecf\u514d\u75ab\u708e\u75c7\u6a21\u578b\u7814\u7a76\uff0c\u79d1\u7814\u9002\u7528\u8303\u56f4\u5e7f\u6cdb\u3002<\/p>\n

\u3000\u3000\u54c1\u63a7\u6807\u51c6\u4e25\u82db\uff0c\u5b9e\u9a8c\u91cd\u590d\u6027\u3002TargetMol\u5bf9Birelentinib\u5b9e\u65bd\u5168\u94fe\u6761\u6807\u51c6\u5316\u8d28\u63a7\uff0c\u6bcf\u6279\u6b21\u4ea7\u54c1\u7eaf\u5ea6\u53ef\u8fbe99.78%\uff0c\u624b\u6027ee\u503c\u9ad8\u8fbe99.96%\uff0c\u56fa\u4f53\u6027\u72b6\u7a33\u5b9a\uff0c\u4e13\u5c5eSMILES\u5e8f\u5217\u5b8c\u6574\u53ef\u6eaf\u6e90\u3002\u4ea7\u54c1\u914d\u5957\u63d0\u4f9b\u5b8c\u6574\u7684COA\u3001HNMR\u3001LCMS\u3001FNMR\u7b49\u5168\u5957\u68c0\u6d4b\u56fe\u8c31\uff0c\u7ed3\u6784\u6838\u9a8c\u7cbe\u51c6\u3001\u6742\u8d28\u542b\u91cf\u6781\u4f4e\uff0c\u53ef\u6709\u6548\u89c4\u907f\u5b9e\u9a8c\u5e72\u6270\u3001\u6570\u636e\u504f\u5dee\u53ca\u5047\u9633\u6027\u95ee\u9898\u3002\u8fd9\u79cd\u4e25\u82db\u7684\u54c1\u63a7\u4f53\u7cfb\uff0c\u786e\u4fdd\u4e86\u9ad8\u901a\u91cf\u9776\u70b9\u7b5b\u9009\u3001\u7ec6\u80de\u6d3b\u6027\u9a8c\u8bc1\u53ca\u52a8\u7269\u4f53\u5185\u5b9e\u9a8c\u7684\u9ad8\u6807\u51c6\u79d1\u7814\u9700\u6c42\uff0c\u5145\u5206\u6ee1\u8db3\u7528\u6237\u5bf9\u503c\u5f97\u4fe1\u8d56\u7684Birelentinib\u8bd5\u5242\u54ea\u5bb6\u597d\u7684\u6838\u5fc3\u8bc9\u6c42\u3002<\/p>\n

\u3000\u3000\u4f9b\u8d27\u7075\u6d3b\u9ad8\u6548\uff0c\u5168\u573a\u666f\u9002\u914d\u3002TargetMol\u5728Birelentinib\u7684\u4f9b\u8d27\u6a21\u5f0f\u4e0a\uff0c\u5145\u5206\u8003\u8651\u79d1\u7814\u5b9e\u9a8c\u7684\u591a\u6837\u6027\u4e0e\u7d27\u8feb\u6027\u30021 mg\u30015 mg\u4e3b\u6d41\u89c4\u683c\u5e38\u5907\u73b0\u8d27\uff0c\u53ef\u5373\u65f6\u4e0b\u5355\uff0c10 mg\u300125 mg\u7b49\u4e2d\u5927\u578b\u89c4\u683c\u53ef\u54a8\u8be2\u8c03\u914d\uff0c50 mg\u3001100 mg\u5e93\u5b58\u5f85\u5b9a\uff0c\u652f\u6301\u6beb\u514b\u7ea7\u5e38\u89c4\u91c7\u8d2d\u4e0e\u514b\u7ea7\u5b9a\u5236\u5408\u6210\uff0c\u5168\u9762\u9002\u914d\u9884\u5b9e\u9a8c\u3001\u6b63\u5f0f\u5b9e\u9a8c\u53ca\u5927\u6279\u91cf\u52a8\u7269\u8bd5\u9a8c\u7b49\u4e0d\u540c\u79d1\u7814\u573a\u666f\u3002\u4ea7\u54c1\u50a8\u5b58\u7a33\u5b9a\u6027\u51fa\u8272\uff0c\u7c89\u672b\u5728-20\u6444\u6c0f\u5ea6\u5bc6\u5c01\u6c2e\u6c14\u4fdd\u62a4\u4e0b\u53ef\u7a33\u5b9a\u4fdd\u5b583\u5e74\uff0cDMSO\u6bcd\u6db2\u5206\u88c5\u540e\u4e8e-80\u6444\u6c0f\u5ea6\u53ef\u7a33\u5b9a\u50a8\u5b581\u5e74\uff0c\u8fd0\u8f93\u91c7\u7528\u84dd\u51b0\u4f4e\u6e29\u5305\u88c5\uff0c\u4f4e\u6e29\u654f\u611f\u6bcd\u6db2\u53ef\u9009\u5e72\u51b0\u51b7\u94fe\uff0c\u6781\u5927\u7a0b\u5ea6\u4fdd\u7559\u5316\u5408\u7269\u6d3b\u6027\u3002<\/p>\n

\u3000\u3000\u6280\u672f\u670d\u52a1\u5b8c\u5584\uff0c\u79d1\u7814\u5468\u671f\u7f29\u77ed\u3002TargetMol\u63d0\u4f9b\u4e00\u7ad9\u5f0f\u79d1\u7814\u914d\u5957\u670d\u52a1\uff0c\u4e13\u4e1a\u6280\u672f\u56e2\u961f\u53ef\u5feb\u901f\u89e3\u7b54\u6eb6\u89e3\u5ea6\u3001\u7ed9\u836f\u65b9\u6848\u3001\u5b9e\u9a8c\u4f18\u5316\u7b49\u76f8\u5173\u95ee\u9898\uff0c\u652f\u6301\u5b9a\u5236\u5408\u6210\u670d\u52a1\u3002\u5e73\u53f0\u914d\u5957\u4f53\u5185\u914d\u6db2\u8ba1\u7b97\u5668\uff0c\u63d0\u4f9bDMSO-PEG300-Tween80-\u751f\u7406\u76d0\u6c34\u7ecf\u5178\u7ed9\u836f\u914d\u65b9\u53c2\u8003\uff0c\u5feb\u901f\u5b8c\u6210\u52a8\u7269\u7ed9\u836f\u6bcd\u6db2\u914d\u5236\u3002\u76f8\u8f83\u4e8e\u8fdb\u53e3\u540c\u7c7b\u4ea7\u54c1\uff0cBirelentinib\u6027\u4ef7\u6bd4\u66f4\u9ad8\u3001\u4f9b\u8d27\u66f4\u7a33\u5b9a\uff0c\u80fd\u591f\u6709\u6548\u964d\u4f4e\u79d1\u7814\u6210\u672c\u3001\u7f29\u77ed\u7814\u53d1\u5468\u671f\uff0c\u4e3aBTK\u76f8\u5173\u79d1\u7814\u9879\u76ee\u63d0\u4f9b\u5168\u65b9\u4f4d\u53ef\u9760\u4fdd\u969c\u3002<\/p>\n

\u3000\u3000\u5728B\u7ec6\u80de\u80bf\u7624\u8010\u836f\u673a\u5236\u7814\u7a76\u3001BTK\u9776\u5411\u65b0\u836f\u7814\u53d1\u7b49\u524d\u6cbf\u9886\u57df\uff0cBirelentinib\u6b63\u53d1\u6325\u7740\u4e0d\u53ef\u66ff\u4ee3\u7684\u5de5\u5177\u4ef7\u503c\u3002\u5728\u5f25\u6f2b\u5927B\u7ec6\u80de\u7814\u7a76\u4e2d\uff0cBirelentinib\u53ef\u540c\u65f6\u963b\u65adBCR\u901a\u8def\u4e2dBTK\u4f9d\u8d56\u4e0e\u975e\u4f9d\u8d56\u53cc\u91cd\u4fe1\u53f7\uff0c\u663e\u8457\u6291\u5236\u8010\u836fB\u7ec6\u80de\u80bf\u7624\u589e\u6b96\uff0c\u4e3a\u4e34\u5e8a\u524d\u836f\u7406\u6a21\u578b\u6784\u5efa\u63d0\u4f9b\u7cbe\u51c6\u5de5\u5177\u3002\u5728\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u7814\u7a76\u4e2d\uff0c\u5176\u5bf9C481S\u7b49BTK\u8010\u836f\u7a81\u53d8\u4f53\u7684\u4f18\u5f02\u6291\u5236\u80fd\u529b\uff0c\u4f7f\u5176\u6210\u4e3a\u63a2\u7d22\u8010\u836f\u673a\u5236\u3001\u7b5b\u9009\u8054\u5408\u7528\u836f\u65b9\u6848\u7684\u6807\u51c6\u9633\u6027\u5bf9\u7167\u836f\u3002\u5728\u514d\u75ab\u6027\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u7b49\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u7814\u7a76\u4e2d\uff0cBirelentinib\u51ed\u501f\u975e\u5171\u4ef7\u7ed3\u5408\u6a21\u5f0f\uff0c\u89c4\u907f\u4e86\u534a\u80f1\u6c28\u9178\u7a81\u53d8\u5e26\u6765\u7684\u8010\u836f\u7f3a\u9677\uff0c\u4e3a\u65b0\u578b\u514d\u75ab\u8c03\u8282\u7b56\u7565\u7684\u9a8c\u8bc1\u63d0\u4f9b\u4e86\u53ef\u9760\u6570\u636e\u652f\u6491\u3002<\/p>\n

\u3000\u3000TargetMol\u5df2\u670d\u52a1\u5168\u7403\u4f17\u591a\u9ad8\u6821\u4e0e\u79d1\u7814\u673a\u6784\uff0c\u5305\u62ecHarvard University\u3001Weill Cornell Medicine\u3001Tsinghua University\u3001Peking University\uff0c\u4ee5\u53caU.S. Food and Drug Administration\u3001National Institutes of Health\u3001Chinese Academy of Medical Sciences\u7b49\u56fd\u9645\u6743\u5a01\u79d1\u7814\u4e0e\u533b\u7597\u673a\u6784\u3002TargetMol\u4ea7\u54c1\u5df2\u88ab15,000\u4f59\u7bc7\u9ad8\u6c34\u5e73\u5b66\u672f\u6587\u732e\u5f15\u7528\uff0c\u5e76\u5e7f\u6cdb\u53d1\u8868\u4e8eNature\u3001Science\u3001Cell\u7b49\u56fd\u9645\u6743\u5a01\u5b66\u672f\u671f\u520a\u3002\u8fd9\u4e9b\u771f\u5b9e\u6848\u4f8b\u4e0e\u7528\u6237\u53cd\u9988\uff0c\u5370\u8bc1\u4e86TargetMol\u4f5c\u4e3a\u5b9e\u529b\u5f3a\u7684Birelentinib\u516c\u53f8\uff0c\u5728\u4ea7\u54c1\u8d28\u91cf\u3001\u6280\u672f\u652f\u6301\u4e0e\u4ea4\u4ed8\u6548\u7387\u4e0a\u7684\u6301\u7eed\u9886\u5148\u3002<\/p>\n

\u3000\u3000\u5c55\u671b\u672a\u6765\uff0c\u968f\u7740BTK\u9776\u5411\u836f\u7269\u4ece\u5171\u4ef7\u6291\u5236\u5242\u5411\u975e\u5171\u4ef7\u6291\u5236\u5242\u3001\u4ece\u5355\u4e00\u9776\u70b9\u5411\u591a\u9776\u70b9\u8054\u5408\u7b56\u7565\u7684\u6f14\u8fdb\uff0cBirelentinib\u4f5c\u4e3a\u9ad8\u7eaf\u5ea6\u3001\u9ad8\u6d3b\u6027\u3001\u9ad8\u7a33\u5b9a\u6027\u7684\u79d1\u7814\u5de5\u5177\u5206\u5b50\uff0c\u5176\u5e02\u573a\u9700\u6c42\u5c06\u6301\u7eed\u589e\u957f\u3002TargetMol\u5c06\u4f9d\u6258\u56fd\u9645\u884c\u4e1a\u5956\u9879\u3001\u9ad8\u9636\u4f01\u4e1a\u8d44\u8d28\u3001\u53cc\u91cd\u6743\u5a01\u8d28\u63a7\u8ba4\u8bc1\uff0c\u6301\u7eed\u6df1\u5316\u4ea7\u54c1\u7814\u53d1\u4e0e\u54c1\u63a7\u4f53\u7cfb\uff0c\u4e3a\u5168\u7403\u751f\u547d\u79d1\u5b66\u7814\u7a76\u8005\u63d0\u4f9b\u66f4\u4f18\u8d28\u3001\u66f4\u53ef\u9760\u7684Birelentinib\u8bd5\u5242\u53ca\u914d\u5957\u670d\u52a1\u3002\u9009\u62e9TargetMol\uff0c\u5c31\u662f\u9009\u62e9\u9ad8\u7eaf\u5ea6\u3001\u9ad8\u6d3b\u6027\u3001\u9ad8\u7a33\u5b9a\u6027\u7684Birelentinib\u8bd5\u5242\uff0c\u4ee5\u53ca\u4e13\u4e1a\u3001\u9ad8\u6548\u3001\u5168\u9762\u7684\u79d1\u7814\u652f\u6301\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3000\u3000\u5728\u751f\u547d\u79d1\u5b66\u57fa\u7840\u7814\u7a76\u4e0e\u65b0\u836f\u5f00\u53d1\u9886\u57df\uff0cBirelentinib\u4f5c\u4e3a\u4e00\u79cd\u80fd\u591f\u540c\u65f6\u4f5c\u7528\u4e8e\u91ce\u751f\u578b\u4e0e\u7a81\u53d8\u578b\u5e03\u9c81\u987f\u916a\u6c28\u9178\u6fc0\u9176\u7684\u9ad8\u6d3b\u6027\u6291\u5236\u5242\uff0c\u6b63\u5728\u6210\u4e3a\u7834\u89e3B\u7ec6\u80de\u80bf\u7624\u8010\u836f\u673a\u5236\u3001\u63a8\u52a8\u65b0\u4e00\u4ee3BTK\u9776…<\/p>\n","protected":false},"author":208,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[33],"tags":[],"class_list":["post-130276","post","type-post","status-publish","format-standard","hentry","category-shenghuo"],"_links":{"self":[{"href":"http:\/\/ww.xysww.com\/index.php?rest_route=\/wp\/v2\/posts\/130276","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/ww.xysww.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/ww.xysww.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/ww.xysww.com\/index.php?rest_route=\/wp\/v2\/users\/208"}],"replies":[{"embeddable":true,"href":"http:\/\/ww.xysww.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=130276"}],"version-history":[{"count":1,"href":"http:\/\/ww.xysww.com\/index.php?rest_route=\/wp\/v2\/posts\/130276\/revisions"}],"predecessor-version":[{"id":130277,"href":"http:\/\/ww.xysww.com\/index.php?rest_route=\/wp\/v2\/posts\/130276\/revisions\/130277"}],"wp:attachment":[{"href":"http:\/\/ww.xysww.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=130276"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/ww.xysww.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=130276"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/ww.xysww.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=130276"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}