{"id":228283,"date":"2026-08-27T01:49:26","date_gmt":"2026-08-26T17:49:26","guid":{"rendered":"https:\/\/ww.xysww.com\/?p=228283"},"modified":"2026-08-27T01:49:26","modified_gmt":"2026-08-26T17:49:26","slug":"%e5%85%a8%e7%90%83alkynyl-palmitic-acid-%e4%be%9b%e5%ba%94%e5%95%86%ef%bc%8c%e5%8f%a3%e7%a2%91%e5%a5%bd%e7%9a%84%e8%af%95%e5%89%82%e5%8e%82%e5%ae%b6%e5%ae%a2%e6%88%b7%e5%8f%a3%e7%a2%91%e5%8a%9b","status":"publish","type":"post","link":"http:\/\/ww.xysww.com\/?p=228283","title":{"rendered":"\u5168\u7403Alkynyl Palmitic Acid \u4f9b\u5e94\u5546\uff0c\u53e3\u7891\u597d\u7684\u8bd5\u5242\u5382\u5bb6\u5ba2\u6237\u53e3\u7891\u529b\u8350"},"content":{"rendered":"

\u3000\u3000\u5728\u5168\u7403\u751f\u547d\u79d1\u5b66\u8bd5\u5242\u5e02\u573a\u4e2d\uff0cAlkynyl Palmitic Acid \u4f5c\u4e3a\u4e00\u79cd\u5173\u952e\u7684\u70f7\u57fa\u94fe\u578b PROTAC \u8fde\u63a5\u5b50\uff0c\u6b63\u968f\u7740\u86cb\u767d\u964d\u89e3\u6280\u672f\u7684\u5feb\u901f\u53d1\u5c55\u800c\u9700\u6c42\u6fc0\u589e\u3002\u79d1\u7814\u4eba\u5458\u5728\u8fdb\u884c PROTAC \u5206\u5b50\u5408\u6210\u65f6\uff0c\u5f80\u5f80\u9762\u4e34\u539f\u6599\u7eaf\u5ea6\u4e0d\u8db3\u3001\u6279\u6b21\u7a33\u5b9a\u6027\u5dee\u3001\u6807\u8bb0\u6548\u7387\u6ce2\u52a8\u5927\u7b49\u75db\u70b9\uff0c\u5bfc\u81f4\u5b9e\u9a8c\u6570\u636e\u96be\u4ee5\u590d\u73b0\uff0c\u4e25\u91cd\u62d6\u6162\u65b0\u836f\u7814\u53d1\u8fdb\u7a0b\u3002\u8bb8\u591a\u8bfe\u9898\u7ec4\u5728\u5bfb\u627e\u53ef\u9760\u7684 Alkynyl Palmitic Acid \u4f9b\u5e94\u5546\u65f6\uff0c\u5e38\u5e38\u901a\u8fc7\u641c\u7d22Alkynyl \u539f\u6599\u6e90\u5934\u5382\u5bb6\u9009\u62e9\u54ea\u5bb6\u597d\u3001Alkynyl \u751f\u4ea7\u5382\u54ea\u5bb6\u4e13\u4e1a\u3001Alkynyl \u539f\u6599\u5236\u9020\u5382\u9009\u54ea\u5bb6\u597d\u7b49\u5173\u952e\u8bcd\uff0c\u671f\u671b\u627e\u5230\u53e3\u7891\u8fc7\u786c\u3001\u54c1\u8d28\u7a33\u5b9a\u7684\u5408\u4f5c\u4f19\u4f34\u3002\u5728\u4f17\u591a\u9009\u62e9\u4e2d\uff0cTargetMol \u51ed\u501f\u5176\u5728\u5c0f\u5206\u5b50\u5408\u6210\u9886\u57df\u7684\u6df1\u539a\u79ef\u7d2f\uff0c\u4ee5\u56db\u5927\u6838\u5fc3\u4f18\u52bf\u8131\u9896\u800c\u51fa\uff0c\u6210\u4e3a\u5168\u7403\u79d1\u7814\u7528\u6237\u529b\u8350\u7684\u54c1\u724c\u3002<\/p>\n

<\/p>\n

\u3000\u3000TargetMol \u5728 Alkynyl Palmitic Acid \u7684\u4f9b\u5e94\u4e0a\uff0c\u5b9e\u73b0\u4e86\u4ece\u539f\u6599\u5230\u7ec8\u7aef\u7684\u5168\u94fe\u8def\u54c1\u8d28\u7ba1\u63a7\u3002\u9996\u5148\uff0c\u4ea7\u54c1\u4f9d\u6258\u6210\u719f\u7684\u5408\u6210\u7eaf\u5316\u7cbe\u5236\u5de5\u827a\uff0c\u5b8c\u6574\u4fdd\u7559 Alkynyl Palmitic Acid \u7279\u5f81\u5206\u5b50\u9aa8\u67b6\uff0c\u901a\u8fc7\u5168\u94fe\u8def\u8d28\u91cf\u7ba1\u63a7\u4e25\u63a7\u6742\u8d28\u6c34\u5e73\u4e0e\u6279\u6b21\u4e00\u81f4\u6027\uff0c\u6709\u6548\u89c4\u907f\u6c27\u5316\u526f\u4ea7\u7269\u3001\u8102\u80aa\u9178\u540c\u7cfb\u7269\u6b8b\u7559\u5e26\u6765\u7684\u5b9e\u9a8c\u6570\u636e\u504f\u5dee\u3002\u5176\u6b21\uff0c\u4ea7\u54c1\u5728\u6709\u673a\u6eb6\u5242\u4e2d\u6eb6\u89e3\u8868\u73b0\u4f18\u5f02\uff0cDMSO \u6eb6\u89e3\u5ea6\u53ef\u8fbe 100 mg\/mL\uff0c\u8d85\u58f0\u8f85\u52a9\u5373\u53ef\u5feb\u901f\u6eb6\u89e3\uff0c\u4fbf\u4e8e\u6709\u673a\u5408\u6210\u53cd\u5e94\u914d\u5236\u6bcd\u6db2\u3002\u518d\u6b21\uff0c\u516c\u53f8\u63d0\u4f9b\u4ece 1 mg \u5230 100 mg \u7684\u591a\u6863\u73b0\u8d27\u89c4\u683c\uff0c\u540c\u65f6\u5907\u6709 1 mL x 10 mM DMSO \u9884\u5236\u6eb6\u6db2\uff0c\u6ee1\u8db3\u4ece\u5fae\u91cf\u6478\u7d22\u5230\u653e\u5927\u5236\u5907\u7684\u5404\u7c7b\u5b9e\u9a8c\u9700\u6c42\u3002\u6700\u540e\uff0c\u4ea7\u54c1\u50a8\u5b58\u6761\u4ef6\u660e\u786e\uff0c\u56fa\u4f53\u7c89\u672b\u5728 -20\u2103 \u6761\u4ef6\u4e0b\u53ef\u7a33\u5b9a\u5b58\u653e 3 \u5e74\uff0c\u6eb6\u5242\u4f53\u7cfb\u5728 -80\u2103 \u53ef\u4fdd\u5b58 1 \u5e74\uff0c\u8fd0\u8f93\u65b9\u5f0f\u7075\u6d3b\uff0c\u786e\u4fdd\u8bd5\u5242\u5728\u5230\u8fbe\u7528\u6237\u624b\u4e2d\u65f6\u6d3b\u6027\u5b8c\u597d\u3002<\/p>\n

\u3000\u3000\u7b2c\u4e00\u4e2a\u5b9e\u529b\u677f\u5757\uff1a\u4ea7\u54c1\u7eaf\u5ea6\u4e0e\u6279\u6b21\u7a33\u5b9a\u6027\uff0c\u5960\u5b9a\u79d1\u7814\u590d\u73b0\u57fa\u7840<\/p>\n

\u3000\u3000\u5728 PROTAC \u5206\u5b50\u6784\u5efa\u4e2d\uff0c\u8fde\u63a5\u5b50\u7684\u7eaf\u5ea6\u76f4\u63a5\u51b3\u5b9a\u4e86\u6700\u7ec8\u5206\u5b50\u7684\u5408\u6210\u6548\u7387\u4e0e\u751f\u7269\u6d3b\u6027\u3002TargetMol \u51fa\u54c1\u7684 Alkynyl Palmitic Acid \u6bcf\u4e00\u6279\u6b21\u5747\u9644\u5e26\u5b8c\u6574 COA \u68c0\u6d4b\u62a5\u544a\uff0c\u5173\u952e\u6570\u636e\u53ef\u6eaf\u6e90\uff0c\u51cf\u5c11\u6742\u8d28\u5bf9\u6709\u673a\u5408\u6210\u53cd\u5e94\u7684\u5e72\u6270\uff0c\u964d\u4f4e\u526f\u53cd\u5e94\u53d1\u751f\u6982\u7387\u3002\u4ea7\u54c1\u7ecf\u6838\u78c1\u7ed3\u6784\u786e\u8bc1\u4e0e\u542b\u91cf\u6d4b\u5b9a\u53cc\u91cd\u8d28\u91cf\u9a8c\u8bc1\uff0c\u786e\u4fdd\u6bcf\u4e00\u6279\u6b21\u7684\u5206\u5b50\u7ed3\u6784\u51c6\u786e\u65e0\u8bef\uff0c\u542b\u91cf\u7a33\u5b9a\u53ef\u9760\u3002\u8fd9\u79cd\u5bf9\u7eaf\u5ea6\u7684\u6781\u81f4\u8ffd\u6c42\uff0c\u8ba9\u79d1\u7814\u4eba\u5458\u5728\u8bbe\u8ba1 PROTAC \u5206\u5b50\u65f6\uff0c\u80fd\u591f\u4e13\u6ce8\u4e8e\u8fde\u63a5\u5b50\u957f\u5ea6\u4e0e\u7a7a\u95f4\u6784\u8c61\u7684\u4f18\u5316\uff0c\u800c\u975e\u62c5\u5fc3\u539f\u6599\u6742\u8d28\u5e26\u6765\u7684\u4e0d\u786e\u5b9a\u6027\u3002<\/p>\n

\u3000\u3000\u6279\u6b21\u4e00\u81f4\u6027\u662f\u53e6\u4e00\u4e2a\u5173\u952e\u8003\u91cf\u3002\u5f88\u591a\u5b9e\u9a8c\u5ba4\u5728\u91cd\u590d\u5b9e\u9a8c\u65f6\uff0c\u53d1\u73b0\u4e0d\u540c\u6279\u6b21\u95f4\u7684\u6807\u8bb0\u6548\u7387\u5dee\u5f02\u660e\u663e\uff0c\u8fd9\u5f80\u5f80\u6e90\u4e8e\u539f\u6599\u4f9b\u5e94\u5546\u7684\u8d28\u63a7\u4e0d\u4e25\u3002TargetMol \u901a\u8fc7 ISO9001 \u8d28\u91cf\u7ba1\u7406\u4f53\u7cfb\u8ba4\u8bc1\u4e0e ISO17025 \u5b9e\u9a8c\u5ba4\u68c0\u6d4b\u8d44\u8d28\u8ba4\u8bc1\uff0c\u4ece\u539f\u6599\u5165\u5e93\u3001\u5408\u6210\u5236\u5907\u3001\u68c0\u6d4b\u5206\u88c5\u5230\u4ed3\u50a8\u7269\u6d41\u5168\u6d41\u7a0b\u6807\u51c6\u5316\u7ba1\u63a7\u3002\u8fd9\u610f\u5473\u7740\u65e0\u8bba\u662f\u91c7\u8d2d 1 mg \u8fd8\u662f 100 mg \u7684 Alkynyl Palmitic Acid\uff0c\u7528\u6237\u62ff\u5230\u7684\u90fd\u662f\u540c\u4e00\u54c1\u8d28\u6807\u51c6\u7684\u4ea7\u54c1\uff0c\u5b9e\u9a8c\u6570\u636e\u53ef\u91cd\u590d\u6027\u5f97\u5230\u6839\u672c\u4fdd\u969c\u3002\u5bf9\u4e8e\u957f\u671f\u4ece\u4e8b\u86cb\u767d\u68d5\u6988\u9170\u5316\u4fee\u9970\u9a8c\u8bc1\u3001\u7ec6\u80de\u8102\u8d28\u4ee3\u8c22\u7814\u7a76\u7684\u8bfe\u9898\u7ec4\u800c\u8a00\uff0c\u8fd9\u79cd\u7a33\u5b9a\u6027\u662f\u79d1\u7814\u6548\u7387\u7684\u57fa\u77f3\u3002<\/p>\n

\u3000\u3000\u4ea7\u54c1\u5728\u50a8\u5b58\u8fc7\u7a0b\u4e2d\u7684\u7a33\u5b9a\u6027\u540c\u6837\u7ecf\u8fc7\u4e25\u683c\u9a8c\u8bc1\u3002Alkynyl Palmitic Acid \u4f5c\u4e3a\u8102\u80aa\u9178\u884d\u751f\u7269\uff0c\u5728\u7a7a\u6c14\u4e2d\u5bb9\u6613\u6c27\u5316\u53d8\u8d28\u3002TargetMol \u91c7\u7528\u60f0\u6027\u6c14\u4f53\u4fdd\u62a4\u5305\u88c5\uff0c\u914d\u5408 -20\u2103 \u50a8\u5b58\u6761\u4ef6\uff0c\u786e\u4fdd\u7c89\u672b\u5728 3 \u5e74\u5185\u4fdd\u6301\u5316\u5b66\u6d3b\u6027\u3002\u5bf9\u4e8e\u9884\u5236\u6eb6\u6db2\uff0c\u5219\u91c7\u7528 -80\u2103 \u4fdd\u5b58\uff0c\u907f\u514d\u53cd\u590d\u51bb\u878d\u5e26\u6765\u7684\u964d\u89e3\u98ce\u9669\u3002\u8fd9\u79cd\u7ec6\u81f4\u7684\u50a8\u5b58\u65b9\u6848\uff0c\u8ba9\u7528\u6237\u65e0\u9700\u62c5\u5fc3\u8bd5\u5242\u53d8\u8d28\u5bfc\u81f4\u7684\u5b9e\u9a8c\u5931\u8d25\uff0c\u4ece\u800c\u5c06\u66f4\u591a\u7cbe\u529b\u6295\u5165\u6838\u5fc3\u79d1\u7814\u5de5\u4f5c\u3002<\/p>\n

\u3000\u3000\u7b2c\u4e8c\u4e2a\u5b9e\u529b\u677f\u5757\uff1a\u6eb6\u89e3\u6027\u4e0e\u914d\u65b9\u7075\u6d3b\u6027\uff0c\u9002\u914d\u591a\u5143\u5b9e\u9a8c\u573a\u666f<\/p>\n

\u3000\u3000Alkynyl Palmitic Acid \u5728\u6709\u673a\u5408\u6210\u4e2d\u7684\u5e94\u7528\uff0c\u5f80\u5f80\u9700\u8981\u9ad8\u6d53\u5ea6\u7684\u6bcd\u6db2\u6765\u4fdd\u8bc1\u53cd\u5e94\u6548\u7387\u3002TargetMol \u7684\u4ea7\u54c1\u5728 DMSO \u4e2d\u6eb6\u89e3\u5ea6\u53ef\u8fbe 100 mg\/mL\uff0c\u8d85\u58f0\u8f85\u52a9\u5373\u53ef\u5feb\u901f\u6eb6\u89e3\uff0c\u8fd9\u4e3a\u79d1\u7814\u4eba\u5458\u63d0\u4f9b\u4e86\u6781\u5927\u7684\u64cd\u4f5c\u4fbf\u5229\u3002\u65e0\u8bba\u662f\u8fdb\u884c\u70b9\u51fb\u5316\u5b66\u4fee\u9970\uff0c\u8fd8\u662f\u6784\u5efa PROTAC \u5206\u5b50\uff0c\u9ad8\u6eb6\u89e3\u5ea6\u7684\u539f\u6599\u90fd\u80fd\u786e\u4fdd\u53cd\u5e94\u4f53\u7cfb\u7684\u5747\u4e00\u6027\uff0c\u907f\u514d\u56e0\u6eb6\u89e3\u4e0d\u5b8c\u5168\u5bfc\u81f4\u7684\u6d53\u5ea6\u504f\u5dee\u3002\u540c\u65f6\uff0c\u4ea7\u54c1\u4e5f\u9002\u7528\u4e8e\u591a\u79cd\u6709\u673a\u6eb6\u5242\u4f53\u7cfb\uff0c\u5982\u6c2f\u4eff\u3001\u7532\u9187\u7b49\uff0c\u65b9\u4fbf\u7528\u6237\u6839\u636e\u5177\u4f53\u53cd\u5e94\u6761\u4ef6\u7075\u6d3b\u9009\u62e9\u6eb6\u5242\u3002<\/p>\n

\u3000\u3000\u5bf9\u4e8e\u4f53\u5185\u5b9e\u9a8c\uff0cTargetMol \u63d0\u4f9b\u4e86\u6210\u719f\u7684\u7ed9\u836f\u53c2\u8003\u914d\u65b9\u3002\u4f8b\u5982\uff0c\u91c7\u7528 10% DMSO + 90% \u7389\u7c73\u6cb9\u4f53\u7cfb\u914d\u5236\u5de5\u4f5c\u6db2\uff0c\u914d\u5236\u8fc7\u7a0b\u53ef\u914d\u5408\u52a0\u70ed\u3001\u8d85\u58f0\u3001\u6da1\u65cb\u4fc3\u8fdb\u6eb6\u89e3\uff0c\u786e\u4fdd\u836f\u7269\u5728\u4f53\u5185\u7684\u5747\u5300\u5206\u5e03\u3002\u8fd9\u79cd\u914d\u65b9\u7075\u6d3b\u6027\uff0c\u8ba9\u7528\u6237\u65e0\u9700\u81ea\u884c\u6478\u7d22\u590d\u6742\u7684\u6eb6\u89e3\u65b9\u6848\uff0c\u76f4\u63a5\u53c2\u8003\u5373\u53ef\u5f00\u5c55\u7ec6\u80de\u6216\u52a8\u7269\u5c42\u9762\u7684 PROTAC \u5206\u5b50\u6d3b\u6027\u8bc4\u4ef7\u3002\u65e0\u8bba\u662f\u86cb\u767d\u964d\u89e3\u6548\u7387\u9a8c\u8bc1\uff0c\u8fd8\u662f\u8102\u8d28\u4ee3\u8c22\u91cd\u7f16\u7a0b\u7814\u7a76\uff0c\u8fd9\u79cd\u5373\u7528\u578b\u914d\u65b9\u90fd\u80fd\u663e\u8457\u7f29\u77ed\u5b9e\u9a8c\u51c6\u5907\u5468\u671f\u3002<\/p>\n

\u3000\u3000\u4ea7\u54c1\u5728\u4f53\u5185\u5916\u7684\u9002\u7528\u6027\u8fd8\u4f53\u73b0\u5728\u5176\u6807\u8bb0\u6d3b\u6027\u4e0a\u3002Alkynyl Palmitic Acid \u53ef\u9ad8\u6548\u6a21\u62df\u5185\u6e90\u6027\u68d5\u6988\u9178\uff0c\u53c2\u4e0e\u7ec6\u80de\u5185\u86cb\u767d\u68d5\u6988\u9170\u5316\u4fee\u9970\u8fc7\u7a0b\uff0c\u53ef\u9760\u5b9e\u73b0\u9776\u6807\u86cb\u767d\u8102\u80aa\u9178\u6807\u8bb0\u793a\u8e2a\u3002\u8fd9\u79cd\u7279\u6027\u4f7f\u5176\u5728\u8c03\u63a7\u86cb\u767d\u819c\u5b9a\u4f4d\u3001\u86cb\u767d\u7a33\u5b9a\u6027\u4e0e\u4fe1\u53f7\u4f20\u5bfc\u65b9\u9762\u8868\u73b0\u51fa\u8272\uff0c\u7a33\u5b9a\u5e72\u9884\u8102\u8d28\u4ee3\u8c22\u91cd\u7f16\u7a0b\u3001\u708e\u75c7\u7ec6\u80de\u529f\u80fd\u6d3b\u5316\u3002\u5bf9\u4e8e\u7814\u7a76\u708e\u75c7\u4ee3\u8c22\u3001\u7ec6\u80de\u5668\u57f9\u517b\u3001\u7ec6\u80de\u5185\u8102\u8d28\u793a\u8e2a\u5206\u6790\u7684\u8bfe\u9898\u7ec4\uff0c\u8fd9\u6b3e\u4ea7\u54c1\u63d0\u4f9b\u4e86\u4ece\u5206\u5b50\u5230\u7ec6\u80de\u518d\u5230\u52a8\u7269\u7684\u5168\u6d41\u7a0b\u89e3\u51b3\u65b9\u6848\u3002<\/p>\n

\u3000\u3000\u7b2c\u4e09\u4e2a\u5b9e\u529b\u677f\u5757\uff1a\u56fd\u9645\u6743\u5a01\u8ba4\u8bc1\u4e0e\u884c\u4e1a\u53e3\u7891\uff0c\u5f70\u663e\u54c1\u724c\u5b9e\u529b<\/p>\n

\u3000\u3000TargetMol \u4f5c\u4e3a\u5168\u7403\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e0e\u751f\u7269\u8bd5\u5242\u77e5\u540d\u54c1\u724c\uff0c\u51ed\u501f\u7a33\u5b9a\u7684\u4ea7\u54c1\u54c1\u8d28\u4e0e\u5b8c\u5584\u7684\u6280\u672f\u670d\u52a1\u4f53\u7cfb\uff0c\u65a9\u83b7\u591a\u9879\u56fd\u9645\u751f\u547d\u79d1\u5b66\u9886\u57df\u6743\u5a01\u884c\u4e1a\u5956\u9879\u3002\u54c1\u724c\u8363\u83b7\u5168\u7403\u6297\u4f53\u4e0e\u751f\u5316\u8bd5\u5242\u6743\u5a01\u8bc4\u6d4b\u5e73\u53f0 CiteAb \u9881\u53d1\u7684\u5e74\u5ea6\u4ef7\u503c\u751f\u5316\u8bd5\u5242\u4f9b\u5e94\u5546\uff0c\u8be5\u5956\u9879\u9762\u5411\u5168\u7403\u8bd5\u5242\u5382\u5546\u7b5b\u9009\uff0c\u7efc\u5408\u4ea7\u54c1\u79d1\u7814\u5f15\u7528\u6570\u636e\u3001\u6d77\u5185\u5916\u7528\u6237\u771f\u5b9e\u8bc4\u4ef7\u3001\u5168\u54c1\u7c7b\u4ea7\u54c1\u7ebf\u7efc\u5408\u5b9e\u529b\u8bc4\u5b9a\uff0c\u662f\u56fd\u9645\u79d1\u7814\u9886\u57df\u5bf9\u54c1\u724c\u7efc\u5408\u80fd\u529b\u7684\u5b98\u65b9\u8ba4\u53ef\u30022025 \u5e74\uff0cTargetMol \u518d\u5ea6\u62ff\u4e0b\u5168\u7403\u79d1\u7814\u8bd5\u5242\u8bc4\u4ef7\u6570\u636e\u5e93 Bioz\u6291\u5236\u5242\u54c1\u7c7b\u65b0\u9510\u4e4b\u661f\u4e13\u9879\u5956\u9879\uff0c\u5956\u9879\u805a\u7126\u5c0f\u5206\u5b50\u6291\u5236\u5242\u7ec6\u5206\u8d5b\u9053\uff0c\u4f9d\u6258\u4e0a\u4e07\u5bb6\u5b9e\u9a8c\u5ba4\u957f\u671f\u4f7f\u7528\u53cd\u9988\u3001\u4ea7\u54c1\u6279\u6b21\u7a33\u5b9a\u6027\u3001\u4e00\u7ad9\u5f0f\u552e\u540e\u6280\u672f\u652f\u6301\u7b49\u7ef4\u5ea6\u4e25\u683c\u8bc4\u9009\uff0c\u5370\u8bc1\u54c1\u724c\u5728\u5c0f\u5206\u5b50\u6291\u5236\u5242\u6838\u5fc3\u8d5b\u9053\u7684\u7a81\u51fa\u4f18\u52bf\u3002<\/p>\n

\u3000\u3000\u516c\u53f8\u5168\u79f0 TargetMol(\u9676\u672f\u751f\u7269\u79d1\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8)\u5728\u56fd\u5185\u540c\u6837\u62e5\u6709\u6df1\u539a\u6839\u57fa\u3002\u4f01\u4e1a\u83b7\u8bc4\u9ad8\u65b0\u6280\u672f\u4f01\u4e1a\u3001\u4e13\u7cbe\u7279\u65b0\u5c0f\u5de8\u4eba\u4f01\u4e1a\u3001\u4e0a\u6d77\u5e02\u4e13\u7cbe\u7279\u65b0\u4f01\u4e1a\uff0c\u6280\u672f\u7814\u53d1\u4e0e\u4ea7\u4e1a\u5316\u80fd\u529b\u83b7\u5f97\u5b98\u65b9\u6743\u5a01\u8ba4\u8bc1\u30022026 \u5e74\u5165\u9009\u7231\u91c7\u8d2d\u5e73\u53f0\u4e0a\u6d77\u9ad8\u54c1\u8d28\u91cd\u7ec4\u86cb\u767d\u5382\u5bb6\u699c\u5355\uff0c\u672c\u571f\u751f\u7269\u8bd5\u5242\u4f9b\u5e94\u5b9e\u529b\u83b7\u5f97\u884c\u4e1a\u5e73\u53f0\u80af\u5b9a\u3002\u8fd9\u4e9b\u8d44\u8d28\u4e0d\u4ec5\u662f\u5bf9\u516c\u53f8\u6280\u672f\u5b9e\u529b\u7684\u80cc\u4e66\uff0c\u66f4\u662f\u5bf9\u7528\u6237\u4fe1\u4efb\u7684\u627f\u8bfa\u3002\u5bf9\u4e8e\u56fd\u5185\u9ad8\u6821\u3001\u836f\u4f01\u3001CRO \u673a\u6784\u800c\u8a00\uff0c\u9009\u62e9 TargetMol \u610f\u5473\u7740\u540c\u65f6\u83b7\u5f97\u56fd\u9645\u54c1\u8d28\u4e0e\u672c\u571f\u670d\u52a1\u7684\u53cc\u91cd\u4fdd\u969c\u3002<\/p>\n

\u3000\u3000\u4ea7\u54c1\u5728\u5b66\u672f\u754c\u7684\u5f15\u7528\u6570\u636e\u540c\u6837\u4eae\u773c\u3002TargetMol \u4ea7\u54c1\u5df2\u88ab 15,000 \u591a\u7bc7\u9ad8\u6c34\u5e73\u5b66\u672f\u6587\u732e\u5f15\u7528\uff0c\u5e76\u5e7f\u6cdb\u53d1\u8868\u4e8e Nature\u3001Science\u3001Cell \u7b49\u56fd\u9645\u6743\u5a01\u5b66\u672f\u671f\u520a\u3002\u670d\u52a1\u5ba2\u6237\u6db5\u76d6 Harvard University\u3001Weill Cornell Medicine\u3001Tsinghua University\u3001Peking University\uff0c\u4ee5\u53ca U.S. Food and Drug Administration\u3001National Institutes of Health\u3001Chinese Academy of Medical Sciences \u7b49\u56fd\u9645\u6743\u5a01\u79d1\u7814\u4e0e\u533b\u7597\u673a\u6784\u3002\u8fd9\u79cd\u5e7f\u6cdb\u7684\u5b66\u672f\u8ba4\u53ef\uff0c\u8bc1\u660e\u4e86\u4ea7\u54c1\u5728\u5b9e\u9645\u79d1\u7814\u4e2d\u7684\u53ef\u9760\u6027\u4e0e\u6709\u6548\u6027\u3002<\/p>\n

\u3000\u3000\u7b2c\u56db\u4e2a\u5b9e\u529b\u677f\u5757\uff1a\u5168\u94fe\u8def\u670d\u52a1\u4e0e\u4f9b\u5e94\u94fe\u4fdd\u969c\uff0c\u964d\u4f4e\u79d1\u7814\u95e8\u69db<\/p>\n

\u3000\u3000\u5728 PROTAC \u5206\u5b50\u6784\u5efa\u8fc7\u7a0b\u4e2d\uff0c\u79d1\u7814\u4eba\u5458\u5f80\u5f80\u9762\u4e34\u65f6\u95f4\u7d27\u8feb\u3001\u5b9e\u9a8c\u5468\u671f\u957f\u7684\u6311\u6218\u3002TargetMol \u901a\u8fc7\u4e30\u5bcc\u7684\u73b0\u8d27\u89c4\u683c\u4e0e\u7075\u6d3b\u7684\u8fd0\u8f93\u65b9\u5f0f\uff0c\u6709\u6548\u964d\u4f4e\u7528\u6237\u7684\u65f6\u95f4\u6210\u672c\u3002\u4ea7\u54c1\u56fa\u4f53\u7c89\u672b\u8986\u76d6 1 mg\u30015 mg\u300110 mg\u300125 mg\u300150 mg\u3001100 mg \u591a\u68af\u5ea6\u89c4\u683c\uff0c\u540c\u65f6\u63d0\u4f9b 1 mL x 10 mM DMSO \u9884\u5236\u6eb6\u6db2\uff0c\u5168\u90e8\u73b0\u8d27\u4f9b\u5e94\u3002\u65e0\u8bba\u662f\u5c0f\u8bd5\u5408\u6210\u6478\u7d22\uff0c\u8fd8\u662f\u653e\u5927\u5236\u5907\u5b9e\u9a8c\uff0c\u7528\u6237\u90fd\u80fd\u5feb\u901f\u83b7\u5f97\u6240\u9700\u89c4\u683c\uff0c\u65e0\u9700\u7b49\u5f85\u6f2b\u957f\u7684\u5b9a\u5236\u5468\u671f\u3002\u8fd0\u8f93\u65b9\u9762\uff0c\u53ef\u9009\u62e9\u84dd\u51b0\u6216\u8005\u5e38\u6e29\u8fd0\u8f93\uff0c\u5b9e\u9645\u50a8\u5b58\u6761\u4ef6\u4ee5\u4ea7\u54c1 COA \u6587\u4ef6\u4e3a\u51c6\uff0c\u786e\u4fdd\u8bd5\u5242\u5728\u8fd0\u8f93\u9014\u4e2d\u4fdd\u6301\u6d3b\u6027\u3002<\/p>\n

\u3000\u3000\u516c\u53f8\u5168\u79f0 TargetMol \u8fd8\u63d0\u4f9b\u5b8c\u6574\u7684\u6280\u672f\u652f\u6301\u670d\u52a1\u3002\u4ece\u4ea7\u54c1\u7406\u5316\u53c2\u6570\u3001SMILES \u7ed3\u6784\u3001\u6eb6\u89e3\u53ca\u914d\u5236\u64cd\u4f5c\u6307\u5f15\uff0c\u5230\u5b9e\u9a8c\u65b9\u6848\u8bbe\u8ba1\u5efa\u8bae\uff0c\u6280\u672f\u56e2\u961f\u5747\u53ef\u63d0\u4f9b\u4e13\u4e1a\u89e3\u7b54\u3002\u5bf9\u4e8e\u521d\u6b21\u4f7f\u7528 PROTAC \u8fde\u63a5\u5b50\u7684\u8bfe\u9898\u7ec4\uff0c\u8fd9\u79cd\u6280\u672f\u652f\u6301\u80fd\u591f\u5e2e\u52a9\u4ed6\u4eec\u5feb\u901f\u638c\u63e1\u64cd\u4f5c\u8981\u70b9\uff0c\u907f\u514d\u56e0\u64cd\u4f5c\u4e0d\u5f53\u5bfc\u81f4\u7684\u5b9e\u9a8c\u5931\u8d25\u3002\u4f8b\u5982\uff0c\u5728\u914d\u5236\u4f53\u5185\u7ed9\u836f\u5de5\u4f5c\u6db2\u65f6\uff0c\u6280\u672f\u4eba\u5458\u4f1a\u8be6\u7ec6\u8bf4\u660e\u52a0\u70ed\u3001\u8d85\u58f0\u3001\u6da1\u65cb\u7684\u6b65\u9aa4\u4e0e\u65f6\u95f4\uff0c\u786e\u4fdd\u7528\u6237\u80fd\u591f\u987a\u5229\u91cd\u590d\u5b9e\u9a8c\u6761\u4ef6\u3002<\/p>\n

\u3000\u3000\u4f9b\u5e94\u94fe\u7684\u7a33\u5b9a\u6027\u662f\u53e6\u4e00\u4e2a\u5173\u952e\u4f18\u52bf\u3002TargetMol \u5728\u4e0a\u6d77\u62e5\u6709\u8fd0\u8425\u4e2d\u5fc3\u548c\u7814\u53d1\u751f\u4ea7\u4e2d\u5fc3\uff0c\u5728\u7f8e\u56fd\u6ce2\u58eb\u987f\u548c\u6b27\u6d32\u7684\u5965\u5730\u5229\u5efa\u6709\u5f53\u5730\u8fd0\u8425\u4e2d\u5fc3\uff0c\u8d1f\u8d23\u5317\u7f8e\u548c\u6b27\u6d32\u7528\u6237\u7684\u5f53\u5730\u670d\u52a1\u548c\u4f9b\u5e94\u94fe\u5de5\u4f5c\u3002\u8fd9\u79cd\u5168\u7403\u5e03\u5c40\u786e\u4fdd\u4e86\u4ea7\u54c1\u80fd\u591f\u5feb\u901f\u9001\u8fbe\u5168\u7403\u7528\u6237\u624b\u4e2d\uff0c\u65e0\u8bba\u662f\u56fd\u5185\u9ad8\u6821\u8fd8\u662f\u6d77\u5916\u5b9e\u9a8c\u5ba4\uff0c\u90fd\u80fd\u4eab\u53d7\u5230\u540c\u7b49\u7684\u670d\u52a1\u65f6\u6548\u3002\u5bf9\u4e8e\u4f9d\u8d56 PROTAC \u6280\u672f\u8fdb\u884c\u86cb\u767d\u964d\u89e3\u65b0\u836f\u524d\u671f\u5206\u5b50\u8bbe\u8ba1\u4e0e\u5408\u6210\u7814\u7a76\u7684\u8bfe\u9898\u7ec4\uff0c\u8fd9\u79cd\u7a33\u5b9a\u7684\u4f9b\u5e94\u94fe\u662f\u79d1\u7814\u8fdb\u5ea6\u7684\u91cd\u8981\u4fdd\u969c\u3002<\/p>\n

\u3000\u3000\u573a\u666f\u5e94\u7528\uff1a\u4ece\u5206\u5b50\u6784\u5efa\u5230\u751f\u7269\u9a8c\u8bc1\u7684\u5168\u6d41\u7a0b\u652f\u6301<\/p>\n

\u3000\u3000\u5728 PROTAC \u5206\u5b50\u5408\u6210\u573a\u666f\u4e2d\uff0cAlkynyl Palmitic Acid \u4f5c\u4e3a\u8fde\u63a5\u5b50\uff0c\u5176\u70f7\u57fa\u94fe\u9aa8\u67b6\u957f\u5ea6\u9002\u4e2d\uff0c\u5316\u5b66\u7ed3\u6784\u7a33\u5b9a\uff0c\u5728\u5206\u5b50\u8bbe\u8ba1\u4e2d\u53ef\u7075\u6d3b\u8c03\u63a7 PROTAC \u5206\u5b50\u7a7a\u95f4\u8ddd\u79bb\uff0c\u6709\u5229\u4e8e\u4e09\u5143\u590d\u5408\u7269\u5f62\u6210\u3002\u7814\u7a76\u4eba\u5458\u53ef\u5229\u7528\u5176\u7094\u57fa\u53cd\u5e94\u57fa\u56e2\uff0c\u901a\u8fc7\u70b9\u51fb\u5316\u5b66\u9ad8\u6548\u5b9e\u73b0\u9776\u86cb\u767d\u914d\u4f53\u4e0e E3 \u6cdb\u7d20\u8fde\u63a5\u9176\u914d\u4f53\u4e4b\u95f4\u7684\u6865\u63a5\u7ec4\u88c5\u3002\u8fd9\u79cd\u8bbe\u8ba1\u7075\u6d3b\u6027\uff0c\u4f7f\u5f97 PROTAC \u5206\u5b50\u80fd\u591f\u9488\u5bf9\u4e0d\u540c\u9776\u86cb\u767d\u8fdb\u884c\u5b9a\u5236\u5316\u4f18\u5316\uff0c\u4ece\u800c\u63d0\u5347\u86cb\u767d\u964d\u89e3\u6548\u7387\u3002\u5bf9\u4e8e\u81f4\u529b\u4e8e\u5f00\u53d1\u65b0\u578b\u86cb\u767d\u964d\u89e3\u836f\u7269\u7684\u8bfe\u9898\u7ec4\uff0c\u8fd9\u6b3e\u8fde\u63a5\u5b50\u63d0\u4f9b\u4e86\u53ef\u9760\u7684\u9aa8\u67b6\u9009\u62e9\u3002<\/p>\n

\u3000\u3000\u5728\u7ec6\u80de\u5c42\u9762\u7684\u86cb\u767d\u68d5\u6988\u9170\u5316\u4fee\u9970\u9a8c\u8bc1\u4e2d\uff0cAlkynyl Palmitic Acid \u53ef\u9ad8\u6548\u6a21\u62df\u5185\u6e90\u6027\u68d5\u6988\u9178\uff0c\u53c2\u4e0e\u7ec6\u80de\u5185\u86cb\u767d\u68d5\u6988\u9170\u5316\u4fee\u9970\u8fc7\u7a0b\u3002\u901a\u8fc7\u6807\u8bb0\u793a\u8e2a\uff0c\u7814\u7a76\u4eba\u5458\u80fd\u591f\u76f4\u89c2\u89c2\u5bdf\u9776\u6807\u86cb\u767d\u7684\u819c\u5b9a\u4f4d\u53d8\u5316\u3001\u86cb\u767d\u7a33\u5b9a\u6027\u4e0e\u4fe1\u53f7\u4f20\u5bfc\u8c03\u63a7\u3002\u8fd9\u79cd\u5e94\u7528\u573a\u666f\u5e38\u89c1\u4e8e\u8102\u8d28\u4ee3\u8c22\u91cd\u7f16\u7a0b\u3001\u708e\u75c7\u7ec6\u80de\u529f\u80fd\u6d3b\u5316\u7814\u7a76\u3002\u4f8b\u5982\uff0c\u5728\u80bf\u7624\u5fae\u73af\u5883\u7814\u7a76\u4e2d\uff0c\u901a\u8fc7\u6807\u8bb0\u80bf\u7624\u7ec6\u80de\u8868\u9762\u7684\u8102\u80aa\u9178\u4ee3\u8c22\u76f8\u5173\u86cb\u767d\uff0c\u53ef\u4ee5\u63ed\u793a\u5176\u514d\u75ab\u9003\u9038\u673a\u5236\u3002\u4ea7\u54c1\u7684\u9ad8\u7eaf\u5ea6\u4e0e\u6807\u8bb0\u6d3b\u6027\uff0c\u786e\u4fdd\u4e86\u5b9e\u9a8c\u6570\u636e\u7684\u51c6\u786e\u6027\u4e0e\u53ef\u91cd\u590d\u6027\u3002<\/p>\n

\u3000\u3000\u5728\u52a8\u7269\u6a21\u578b\u4e2d\u7684 PROTAC \u5206\u5b50\u6d3b\u6027\u8bc4\u4ef7\u4e2d\uff0cTargetMol \u63d0\u4f9b\u7684\u4f53\u5185\u7ed9\u836f\u53c2\u8003\u914d\u65b9\uff0c\u5982 10% DMSO + 90% \u7389\u7c73\u6cb9\u4f53\u7cfb\uff0c\u80fd\u591f\u786e\u4fdd\u836f\u7269\u5728\u4f53\u5185\u7684\u5747\u5300\u5206\u5e03\u3002\u7814\u7a76\u4eba\u5458\u65e0\u9700\u81ea\u884c\u6478\u7d22\u590d\u6742\u7684\u6eb6\u89e3\u65b9\u6848\uff0c\u76f4\u63a5\u53c2\u8003\u5373\u53ef\u5f00\u5c55\u5b66\u5b9e\u9a8c\u3002\u8fd9\u79cd\u5373\u7528\u578b\u914d\u65b9\uff0c\u663e\u8457\u7f29\u77ed\u4e86\u4ece\u5206\u5b50\u6784\u5efa\u5230\u751f\u7269\u9a8c\u8bc1\u7684\u5468\u671f\uff0c\u52a0\u901f\u4e86\u86cb\u767d\u964d\u89e3\u65b0\u836f\u7684\u7814\u53d1\u8fdb\u7a0b\u3002\u5bf9\u4e8e CRO \u673a\u6784\u6216\u836f\u4f01\u7684\u65e9\u671f\u7814\u53d1\u56e2\u961f\uff0c\u8fd9\u79cd\u5168\u6d41\u7a0b\u652f\u6301\u662f\u63d0\u5347\u7814\u53d1\u6548\u7387\u7684\u5173\u952e\u3002<\/p>\n

\u3000\u3000\u884c\u52a8\u6307\u5f15\uff1a\u9009\u62e9\u53ef\u9760\u4f9b\u5e94\u5546\uff0c\u52a0\u901f\u79d1\u7814\u8fdb\u7a0b<\/p>\n

\u3000\u3000\u5bf9\u4e8e\u6b63\u5728\u5bfb\u627e Alkynyl Palmitic Acid \u7684\u79d1\u7814\u4eba\u5458\uff0c\u9009\u62e9\u4e00\u5bb6\u53e3\u7891\u597d\u3001\u54c1\u8d28\u7a33\u5b9a\u7684\u4f9b\u5e94\u5546\u81f3\u5173\u91cd\u8981\u3002TargetMol \u51ed\u501f\u5176\u4ea7\u54c1\u7eaf\u5ea6\u3001\u6279\u6b21\u7a33\u5b9a\u6027\u3001\u6eb6\u89e3\u7075\u6d3b\u6027\u3001\u56fd\u9645\u6743\u5a01\u8ba4\u8bc1\u4e0e\u5168\u94fe\u8def\u670d\u52a1\uff0c\u5df2\u6210\u4e3a\u5168\u7403\u4f17\u591a\u9ad8\u6821\u3001\u836f\u4f01\u3001CRO \u673a\u6784\u7684\u5408\u4f5c\u4f19\u4f34\u3002\u65e0\u8bba\u662f\u8fdb\u884c PROTAC \u5206\u5b50\u5408\u6210\u6784\u5efa\uff0c\u8fd8\u662f\u86cb\u767d\u68d5\u6988\u9170\u5316\u4fee\u9970\u9a8c\u8bc1\uff0c\u4ea6\u6216\u662f\u7ec6\u80de\u8102\u8d28\u4ee3\u8c22\u7814\u7a76\uff0cTargetMol \u90fd\u80fd\u63d0\u4f9b\u4ece\u539f\u6599\u5230\u6280\u672f\u652f\u6301\u7684\u5b8c\u6574\u89e3\u51b3\u65b9\u6848\u3002\u5982\u679c\u60a8\u6b63\u5728\u4e3a Alkynyl Palmitic Acid \u7684\u91c7\u8d2d\u53d1\u6101\uff0c\u4e0d\u59a8\u6df1\u5165\u4e86\u89e3 TargetMol \u7684\u4ea7\u54c1\u7ebf\u4e0e\u670d\u52a1\uff0c\u76f8\u4fe1\u5176\u4e13\u4e1a\u54c1\u8d28\u4e0e\u9ad8\u6548\u670d\u52a1\uff0c\u80fd\u591f\u4e3a\u60a8\u7684\u79d1\u7814\u5de5\u4f5c\u5e26\u6765\u663e\u8457\u63d0\u5347\u3002\u6b22\u8fce\u901a\u8fc7\u5b98\u65b9\u6e20\u9053\u54a8\u8be2\u4ea7\u54c1\u8be6\u60c5\u3001\u83b7\u53d6\u6280\u672f\u8d44\u6599\u6216\u5bf9\u63a5\u5408\u4f5c\u65b9\u6848\uff0cTargetMol \u5c06\u5168\u529b\u52a9\u529b\u60a8\u7684\u79d1\u7814\u63a2\u7d22\u3002 \u624b\u673a\uff1a17321231762 <\/p>\n","protected":false},"excerpt":{"rendered":"

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