{"id":383348,"date":"2026-09-24T13:59:36","date_gmt":"2026-09-24T05:59:36","guid":{"rendered":"https:\/\/ww.xysww.com\/?p=383348"},"modified":"2026-09-24T13:59:36","modified_gmt":"2026-09-24T05:59:36","slug":"glp-1r-agonist-dmb-%e8%86%9c%e5%8f%97%e4%bd%93%e5%89%82-%e7%8e%b0%e8%b4%a7%e6%89%b9%e6%ac%a1coa%e9%bd%90%e5%85%a8-%e6%94%af%e6%8c%81nmr%e8%b4%a8%e8%b0%b1%e6%a3%80%e6%b5%8b%e6%8a%a5%e5%91%8a","status":"publish","type":"post","link":"http:\/\/ww.xysww.com\/?p=383348","title":{"rendered":"GLP-1R Agonist DMB \u819c\u53d7\u4f53\u5242 \u73b0\u8d27\u6279\u6b21COA\u9f50\u5168 \u652f\u6301NMR\u8d28\u8c31\u68c0\u6d4b\u62a5\u544a"},"content":{"rendered":"

GLP-1R\u4e0e\u7cd6\u4ee3\u8c22\u79d1\u7814\u9886\u57df\u7684\u57fa\u7840\u79d1\u666e<\/strong><\/h2>\n

\u3000\u3000\u505a\u4ee3\u8c22\u76f8\u5173\u57fa\u7840\u7814\u7a76\u7684\u79d1\u7814\u4eba\uff0c\u5bf9GLP-1R\u8fd9\u4e2a\u9776\u70b9\u4e00\u5b9a\u4e0d\u4f1a\u964c\u751f\u3002\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1\u53d7\u4f53(GLP-1R)\u662fG\u86cb\u767d\u5076\u8054\u53d7\u4f53\u5bb6\u65cf\u7684\u91cd\u8981\u6210\u5458\uff0c\u4e3b\u8981\u5206\u5e03\u5728\u80f0\u5c9b\u03b2\u7ec6\u80de\u3001\u80a0\u9053\u3001\u7cfb\u7edf\u7b49\u591a\u79cd\u7ec4\u7ec7\u4e2d\uff0c\u662f\u5f53\u4e0b2\u578b\u7cd6\u5c3f\u75c5\u3001\u80a5\u80d6\u7b49\u4ee3\u8c22\u75be\u75c5\u7814\u7a76\u9886\u57df\u7684\u70ed\u95e8\u9776\u70b9\u3002<\/p>\n

<\/p>\n

\u3000\u3000GLP-1R\u88ab\u540e\uff0c\u53ef\u4ee5\u901a\u8fc7cAMP\u4fe1\u53f7\u901a\u8def\u4fc3\u8fdb\u80f0\u5c9b\u03b2\u7ec6\u80de\u5728\u8461\u8404\u7cd6\u6d53\u5ea6\u5347\u9ad8\u7684\u6761\u4ef6\u4e0b\u5206\u6ccc\u80f0\u5c9b\u7d20\uff0c\u540c\u65f6\u8fd8\u80fd\u6291\u5236\u80f0\u9ad8\u8840\u7cd6\u7d20\u5206\u6ccc\u3001\u5ef6\u7f13\u80c3\u6392\u7a7a\uff0c\u6700\u7ec8\u8fbe\u5230\u8c03\u8282\u8840\u7cd6\u7a33\u6001\u7684\u6548\u679c\u3002\u6b63\u662f\u56e0\u4e3a\u660e\u786e\u7684\u751f\u7406\u529f\u80fd\u548c\u4e34\u5e8a\u8f6c\u5316\u4ef7\u503c\uff0c\u56f4\u7ed5GLP-1R\u7684\u673a\u5236\u7814\u7a76\u3001\u65b0\u836f\u7b5b\u9009\u4e00\u76f4\u662f\u4ee3\u8c22\u9886\u57df\u7684\u7814\u7a76\u70ed\u70b9\uff0c\u800c\u4e00\u6b3e\u6d3b\u6027\u660e\u786e\u3001\u7eaf\u5ea6\u8fbe\u6807\u3001\u9776\u70b9\u7279\u5f02\u6027\u5f3a\u7684GLP-1R\u6fc0\u52a8\u5242\u5de5\u5177\u5316\u5408\u7269<\/strong>\uff0c\u662f\u987a\u5229\u63a8\u8fdb\u5b9e\u9a8c\u7684\u57fa\u7840\u524d\u63d0\u3002<\/p>\n

\u3000\u3000\u76ee\u524d\u5df2\u7ecf\u4e0a\u5e02\u7684GLP-1R\u6fc0\u52a8\u5242\u5927\u591a\u662f\u591a\u80bd\u7c7b\u836f\u7269\uff0c\u8fd9\u7c7b\u5206\u5b50\u7ed3\u6784\u8f83\u5927\uff0c\u5728\u4f53\u5916\u7ec6\u80de\u5b9e\u9a8c\u548c\u5c0f\u5206\u5b50\u673a\u5236\u7814\u7a76\u4e2d\u5b58\u5728\u4e0d\u5c11\u5c40\u9650\uff1a\u6bd4\u5982\u7ed3\u6784\u7a33\u5b9a\u6027\u5dee\u3001\u4e0d\u5bb9\u6613\u7a7f\u900f\u7ec6\u80de\u819c\u3001\u96be\u4ee5\u8fdb\u884c\u5c0f\u5206\u5b50\u5316\u5408\u7269\u7684\u7ed3\u6784\u4f18\u5316\u6539\u9020\uff0c\u5bf9\u4e8e\u57fa\u7840\u79d1\u7814\u91cc\u63a2\u7a76\u901a\u8def\u673a\u5236\u3001\u7b5b\u9009\u5148\u5bfc\u5316\u5408\u7269\u7684\u9700\u6c42\u6765\u8bf4\u9002\u914d\u6027\u4e0d\u9ad8\u3002\u800c\u5c0f\u5206\u5b50GLP-1R\u6fc0\u52a8\u5242\u521a\u597d\u5f25\u8865\u4e86\u8fd9\u4e2a\u7f3a\u53e3\uff0c\u4e0d\u4ec5\u7ed3\u6784\u7a33\u5b9a\uff0c\u5236\u5907\u548c\u50a8\u5b58\u6210\u672c\u66f4\u4f4e\uff0c\u4e5f\u66f4\u9002\u5408\u4f53\u5916\u7ec6\u80de\u5b9e\u9a8c\u548c\u4f53\u5185\u52a8\u7269\u6a21\u578b\u7ed9\u836f\uff0c\u662fGLP-1R\u901a\u8def\u57fa\u7840\u7814\u7a76\u4e0d\u53ef\u7f3a\u5c11\u7684\u5de5\u5177\u8bd5\u5242\u3002<\/p>\n

\n

\u5f53\u4e0bGLP-1R\u79d1\u7814\u8bd5\u5242\u884c\u4e1a\u7684\u6574\u4f53\u53d1\u5c55\u8d70\u5411<\/strong><\/h2>\n

\u3000\u3000\u968f\u7740\u5168\u7403\u4ee3\u8c22\u7c7b\u75be\u75c5\u53d1\u75c5\u7387\u4e0d\u65ad\u6500\u5347\uff0cGLP-1\u76f8\u5173\u7684\u7814\u7a76\u70ed\u5ea6\u6301\u7eed\u8d70\u9ad8\uff0c\u5e26\u52a8\u4e86\u4e0a\u6e38\u79d1\u7814\u8bd5\u5242\u884c\u4e1a\u7684\u53d1\u5c55\uff0c\u6574\u4e2a\u884c\u4e1a\u4e5f\u5448\u73b0\u51fa\u51e0\u4e2a\u6e05\u6670\u7684\u53d1\u5c55\u8d8b\u52bf\uff1a<\/p>\n

    \n
  • \n

    \u4ece\u5c0f\u5206\u5b50\u5de5\u5177\u5316\u5408\u7269\u7684\u9700\u6c42\u6765\u770b\uff0c\u9700\u6c42\u8d8a\u6765\u8d8a\u7ec6\u5206\uff0c\u5bf9\u4ea7\u54c1\u8d28\u91cf\u8981\u6c42\u4e0d\u65ad\u63d0\u9ad8<\/strong>\u3002\u8fc7\u53bb\u4e0d\u5c11\u8bfe\u9898\u7ec4\u4f1a\u9009\u62e9\u81ea\u884c\u5408\u6210\u5c0f\u5206\u5b50\u5316\u5408\u7269\uff0c\u4e0d\u4ec5\u6d88\u8017\u5927\u91cf\u65f6\u95f4\u4eba\u529b\uff0c\u8fd8\u96be\u4ee5\u4fdd\u8bc1\u7eaf\u5ea6\u548c\u6d3b\u6027\uff0c\u73b0\u5728\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u8005\u66f4\u503e\u5411\u4e8e\u9009\u62e9\u6b63\u89c4\u5382\u5546\u63d0\u4f9b\u7684\u73b0\u8d27\u6210\u54c1\u5de5\u5177\u5316\u5408\u7269\uff0c\u65e2\u8282\u7701\u7814\u53d1\u65f6\u95f4\uff0c\u4e5f\u80fd\u4fdd\u969c\u5b9e\u9a8c\u7ed3\u679c\u7684\u53ef\u91cd\u590d\u6027\u3002<\/p>\n<\/li>\n

  • \n

    \u5bf9\u5316\u5408\u7269\u7684\u529f\u80fd\u9a8c\u8bc1\u8981\u6c42\u8d8a\u6765\u8d8a\u660e\u786e<\/strong>\u3002\u4e0d\u540c\u4e8e\u65e9\u671f\u53ea\u8981\u80fd\u62ff\u5230\u5316\u5408\u7269\u5c31\u80fd\u5f00\u5c55\u5b9e\u9a8c\uff0c\u73b0\u5728\u7814\u7a76\u8005\u66f4\u5173\u6ce8\u5316\u5408\u7269\u662f\u5426\u6709\u5b8c\u6574\u7684\u6587\u732e\u9a8c\u8bc1\u6570\u636e\uff0c\u9776\u70b9\u4eb2\u548c\u529b\u3001\u4f53\u5916\u4f53\u5185\u6d3b\u6027\u662f\u5426\u660e\u786e\uff0c\u4f5c\u7528\u673a\u5236\u662f\u5426\u6e05\u6670\uff0c\u8fd9\u4e9b\u6570\u636e\u53ef\u4ee5\u76f4\u63a5\u4e3a\u8bba\u6587\u63d0\u4f9b\u652f\u6491\uff0c\u51cf\u5c11\u524d\u671f\u9884\u5b9e\u9a8c\u7684\u6478\u7d22\u6210\u672c\u3002<\/p>\n<\/li>\n

  • \n

    \u4ea7\u54c1\u89c4\u683c\u548c\u670d\u52a1\u8981\u6c42\u8d8a\u6765\u8d8a\u591a\u6837\u5316<\/strong>\u3002\u4e0d\u540c\u8bfe\u9898\u7ec4\u7684\u5b9e\u9a8c\u89c4\u6a21\u4e0d\u540c\uff0c\u5c0f\u5230\u51e0\u6beb\u514b\u7684\u4f53\u5916\u7b5b\u9009\uff0c\u5927\u5230\u51e0\u5341\u6beb\u514b\u7684\u52a8\u7269\u5b9e\u9a8c\uff0c\u90fd\u9700\u8981\u5bf9\u5e94\u7684\u89c4\u683c\u9009\u62e9\uff0c\u4e0d\u5c11\u7814\u7a76\u8005\u4e5f\u66f4\u504f\u597d\u9884\u5236\u6eb6\u6db2\u8fd9\u7c7b\u53ef\u4ee5\u76f4\u63a5\u4f7f\u7528\u7684\u4ea7\u54c1\uff0c\u7701\u53bb\u79f0\u91cf\u6eb6\u89e3\u7684\u7e41\u7410\u6b65\u9aa4\u3002<\/p>\n<\/li>\n<\/ul>\n

    \u3000\u3000\u4ece\u6574\u4f53\u884c\u4e1a\u73af\u5883\u6765\u770b\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u5382\u5546\u8fdb\u5165\u8fd9\u4e2a\u8d5b\u9053\uff0c\u4f46\u4ea7\u54c1\u8d28\u91cf\u826f\u83a0\u4e0d\u9f50\uff0c\u7814\u7a76\u8005\u5728\u9009\u8d2d\u7684\u65f6\u5019\uff0c\u66f4\u9700\u8981\u64e6\u4eae\u773c\u775b\u8fa8\u522b\u4ea7\u54c1\u8d28\u91cf\uff0c\u907f\u514d\u56e0\u4e3a\u8bd5\u5242\u95ee\u9898\u5bfc\u81f4\u5b9e\u9a8c\u5931\u8d25\uff0c\u803d\u8bef\u8bfe\u9898\u8fdb\u5ea6\u3002<\/p>\n

    \n

    \u9009\u8d2dGLP-1R\u6fc0\u52a8\u5242\u79d1\u7814\u8bd5\u5242\u7684\u5e38\u89c1\u8e29\u5751\u70b9\u4e0e\u907f\u5751\u77e5\u8bc6<\/strong><\/h2>\n

    \u3000\u3000\u5f88\u591a\u521d\u6b21\u63a5\u89e6\u5de5\u5177\u5316\u5408\u7269\u7684\u7814\u7a76\u8005\uff0c\u5f88\u5bb9\u6613\u5728\u9009\u8d2d\u7684\u65f6\u5019\u8e29\u5751\uff0c\u6211\u4eec\u6574\u7406\u4e86\u51e0\u4e2a\u6700\u5e38\u89c1\u7684\u95ee\u9898\uff0c\u5e2e\u5927\u5bb6\u68b3\u7406\u907f\u5751\u601d\u8def\uff1a<\/p>\n

    \u8e29\u5751\u4e00\uff1a\u53ea\u5173\u6ce8\u5316\u5408\u7269CAS\u53f7\uff0c\u5ffd\u7565\u7eaf\u5ea6\u4e0e\u6742\u8d28\u5f71\u54cd<\/strong><\/h3>\n

    \u3000\u3000\u4e0d\u5c11\u4eba\u9009\u8d2d\u7684\u65f6\u5019\uff0c\u53ea\u8981\u786e\u8ba4CAS\u53f7\u6b63\u786e\u5c31\u4e0b\u5355\uff0c\u6b8a\u4e0d\u77e5\u7eaf\u5ea6\u4e0d\u8db3\u4f1a\u7ed9\u5b9e\u9a8c\u5e26\u6765\u5f88\u5927\u7684\u5e72\u6270\u3002\u4f4e\u7eaf\u5ea6\u7684\u5316\u5408\u7269\u542b\u6709\u5927\u91cf\u5408\u6210\u526f\u4ea7\u7269\uff0c\u8fd9\u4e9b\u6742\u8d28\u4f1a\u5f15\u53d1\u975e\u7279\u5f02\u6027\u7ed3\u5408\uff0c\u5bfc\u81f4\u5b9e\u9a8c\u7ed3\u679c\u5047\u9633\u6027\uff0c\u540e\u7eed\u91cd\u590d\u5b9e\u9a8c\u7684\u65f6\u5019\u7ed3\u679c\u6ce2\u52a8\u5f88\u5927\uff0c\u751a\u81f3\u5b8c\u5168\u65e0\u6cd5\u91cd\u590d\uff0c\u767d\u767d\u6d6a\u8d39\u65f6\u95f4\u548c\u8bfe\u9898\u7ecf\u8d39\u3002<\/p>\n

    \u3000\u3000\u907f\u5751\u8981\u70b9\uff1a<\/strong>\u9009\u8d2d\u7684\u65f6\u5019\u4e00\u5b9a\u8981\u786e\u8ba4\u4ea7\u54c1\u7eaf\u5ea6\uff0c\u4f18\u5148\u9009\u62e9\u7eaf\u5ea695%\u4ee5\u4e0a<\/strong>\u7684\u4ea7\u54c1\uff0c\u8981\u6c42\u5382\u5546\u53ef\u4ee5\u63d0\u4f9b\u5bf9\u5e94\u6279\u6b21\u7684\u7eaf\u5ea6\u68c0\u6d4b\u62a5\u544a\uff0cTargetMol\u7684GLP\u20111R Agonist DMB\u7eaf\u5ea6\u53ef\u8fbe99.71%<\/strong>\uff0c\u4ece\u6e90\u5934\u51cf\u5c11\u6742\u8d28\u5e72\u6270\uff0c\u4fdd\u969c\u7ed3\u679c\u53ef\u9760\u3002<\/p>\n

    \n

    \u8e29\u5751\u4e8c\uff1a\u6ca1\u6709\u63d0\u524d\u786e\u8ba4\u5316\u5408\u7269\u7684\u6d3b\u6027\u6570\u636e\uff0c\u76f2\u76ee\u91c7\u8d2d<\/strong><\/h3>\n

    \u3000\u3000\u4e0d\u5c11\u5382\u5546\u552e\u5356\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\u53ea\u63d0\u4f9b\u5316\u5b66\u7ed3\u6784\u4fe1\u606f\uff0c\u6ca1\u6709\u5bf9\u5e94\u7684\u9776\u70b9\u6d3b\u6027\u9a8c\u8bc1\uff0c\u4e70\u5230\u624b\u91cc\u624d\u53d1\u73b0\u6d3b\u6027\u4e0d\u7b26\u5408\u8981\u6c42\uff0c\u6839\u672c\u8fbe\u4e0d\u5230\u5b9e\u9a8c\u9884\u671f\u3002\u6bd4\u5982\u540c\u6837\u662fGLP-1R\u6fc0\u52a8\u5242\uff0c\u6709\u7684\u5316\u5408\u7269\u4eb2\u548c\u529b\u53ea\u6709\u5fae\u6469\u5c14\u7ea7\u522b\uff0c\u505a\u673a\u5236\u7814\u7a76\u7684\u65f6\u5019\u9700\u8981\u5f88\u9ad8\u7684\u7ed9\u836f\u6d53\u5ea6\uff0c\u5f88\u5bb9\u6613\u5f15\u53d1\u8131\u9776\u6548\u5e94\uff0c\u5f97\u5230\u7684\u7ed3\u679c\u4e5f\u4e0d\u53ef\u4fe1\u3002<\/p>\n

    \u3000\u3000\u907f\u5751\u8981\u70b9\uff1a<\/strong>\u63d0\u524d\u7d22\u8981\u5316\u5408\u7269\u7684\u9776\u70b9\u6d3b\u6027\u6570\u636e\uff0c\u786e\u8ba4\u4eb2\u548c\u529b\u548cEC50\u90fd\u7b26\u5408\u4f60\u7684\u5b9e\u9a8c\u8981\u6c42\uff0c\u4f18\u5148\u9009\u62e9\u6709\u6587\u732e\u9a8c\u8bc1\u6d3b\u6027\u7684\u4ea7\u54c1\u3002GLP\u20111R Agonist DMB\u9488\u5bf9\u91cd\u7ec4\u4ebaGLP\u20111R\u7684KB\u503c\u4e3a26.3 nM<\/strong>\uff0c\u4f53\u5916\u6291\u5236\u798f\u53f8\u53ef\u6797\u8bf1\u5bfccAMP\u7d2f\u79ef\u7684EC\u2085\u2080\u4e3a101 nM<\/strong>\uff0c\u6d3b\u6027\u6570\u636e\u660e\u786e\uff0c\u673a\u5236\u6e05\u6670\uff0c\u53ef\u76f4\u63a5\u4e3a\u8bba\u6587\u63d0\u4f9b\u652f\u6491\u3002<\/p>\n

    \n

    \u8e29\u5751\u4e09\uff1a\u5ffd\u7565\u6eb6\u89e3\u5ea6\u548c\u50a8\u5b58\u6761\u4ef6\uff0c\u5bfc\u81f4\u5316\u5408\u7269\u6eb6\u89e3\u5931\u8d25\u6216\u8005\u5931\u6d3b<\/strong><\/h3>\n

    \u3000\u3000\u5f88\u591a\u65b0\u624b\u7814\u7a76\u8005\u5bb9\u6613\u5ffd\u7565\u8fd9\u4e2a\u95ee\u9898\uff0c\u62ff\u5230\u56fa\u4f53\u5316\u5408\u7269\u624d\u53d1\u73b0\uff0c\u6eb6\u89e3\u5ea6\u6839\u672c\u8fbe\u4e0d\u5230\u81ea\u5df1\u9700\u8981\u7684\u6d53\u5ea6\uff0c\u6216\u8005\u50a8\u5b58\u65b9\u6cd5\u4e0d\u5bf9\uff0c\u7528\u4e86\u51e0\u6b21\u4e4b\u540e\u5316\u5408\u7269\u5931\u6d3b\uff0c\u5b9e\u9a8c\u7ed3\u679c\u8d8a\u6765\u8d8a\u5dee\u3002<\/p>\n

    \u3000\u3000\u907f\u5751\u8981\u70b9\uff1a<\/strong>\u9009\u8d2d\u7684\u65f6\u5019\u63d0\u524d\u786e\u8ba4\u5316\u5408\u7269\u5728\u5e38\u7528\u6eb6\u5242\u4e2d\u7684\u6eb6\u89e3\u5ea6\uff0c\u6839\u636e\u81ea\u5df1\u7684\u5b9e\u9a8c\u4f53\u7cfb\u9009\u62e9\u5408\u9002\u7684\u4ea7\u54c1\u5f62\u6001\u3002GLP\u20111R Agonist DMB\u5728DMSO\u4e2d\u6eb6\u89e3\u5ea6\u53ef\u8fbe9.00 mg\/mL(25.84 mM)<\/strong>\uff0c\u6ee1\u8db3\u5927\u591a\u6570\u5b9e\u9a8c\u7684\u6d53\u5ea6\u9700\u6c42\uff0c\u7c89\u672b\u5efa\u8bae-20\u2103\u907f\u5149\u4fdd\u5b58\uff0c\u6709\u6548\u671f3\u5e74\uff0cDMSO\u6bcd\u6db2\u5206\u88c5\u540e-80\u2103\u4fdd\u5b58\uff0c\u6709\u6548\u671f1\u5e74\uff0c\u6309\u7167\u8981\u6c42\u50a8\u5b58\u5c31\u53ef\u4ee5\u4fdd\u6301\u6d3b\u6027\u7a33\u5b9a\u3002<\/p>\n

    \n

    \u8e29\u5751\u56db\uff1a\u4e0d\u7d22\u8981\u8d28\u68c0\u62a5\u544a\uff0c\u4ea7\u54c1\u8d28\u91cf\u6ca1\u6709\u4fdd\u969c<\/strong><\/h3>\n

    \u3000\u3000\u4e0d\u5c11\u5c0f\u5382\u5546\u51fa\u4e8e\u6210\u672c\u8003\u8651\uff0c\u4e0d\u4f1a\u7ed9\u6bcf\u4e00\u6279\u6b21\u4ea7\u54c1\u505a\u5b8c\u6574\u8d28\u68c0\uff0c\u4e0d\u540c\u6279\u6b21\u4e4b\u95f4\u7eaf\u5ea6\u548c\u6d3b\u6027\u5dee\u5f02\u5f88\u5927\uff0c\u5bfc\u81f4\u5b9e\u9a8c\u91cd\u590d\u6027\u5dee\uff0c\u751a\u81f3\u6295\u7a3f\u7684\u65f6\u5019\u88ab\u5ba1\u7a3f\u4eba\u8981\u6c42\u63d0\u4f9b\u8d28\u68c0\u6570\u636e\uff0c\u62ff\u4e0d\u51fa\u6765\u76f4\u63a5\u5f71\u54cd\u6587\u7ae0\u63a5\u6536\u3002<\/p>\n

    \u3000\u3000\u907f\u5751\u8981\u70b9\uff1a<\/strong>\u9009\u62e9\u53ef\u4ee5\u63d0\u4f9b\u5b8c\u6574\u8d28\u68c0\u62a5\u544a\u7684\u5382\u5546\uff0c\u6bcf\u4e00\u6279\u6b21\u4ea7\u54c1\u90fd\u8981\u6709\u5bf9\u5e94\u7684COA\u8bc1\u4e66\uff0c\u5305\u542bHPLC\u3001HNMR\u7b49\u68c0\u6d4b\u6570\u636e\uff0c\u4fdd\u969c\u6bcf\u4e00\u6b21\u5b9e\u9a8c\u7684\u539f\u6599\u90fd\u7a33\u5b9a\u53ef\u9760\u3002TargetMol\u7684GLP\u20111R Agonist DMB\u6bcf\u4e00\u6279\u6b21\u90fd\u9644\u5e26\u5b8c\u6574\u7684COA\u62a5\u544a\uff0c\u652f\u6301HPLC\u548cHNMR\u8d28\u68c0\uff0c\u54c1\u8d28\u6709\u636e\u53ef\u67e5\u3002<\/p>\n

    \n

    \u73b0\u9636\u6bb5GLP-1R\u79d1\u7814\u9886\u57df\u6f5c\u85cf\u7684\u53d1\u5c55\u673a\u9047<\/strong><\/h2>\n

    \u3000\u3000GLP-1R\u76f8\u5173\u7814\u7a76\u4ece\u53d1\u73b0\u5230\u73b0\u5728\u5df2\u7ecf\u6709\u51e0\u5341\u5e74\u7684\u5386\u53f2\uff0c\u4f46\u76f4\u5230\u4eca\u5929\u4f9d\u7136\u662f\u4ee3\u8c22\u9886\u57df\u7684\u7814\u7a76\u70ed\u70b9\uff0c\u8fd8\u6709\u5f88\u591a\u503c\u5f97\u6316\u6398\u7684\u65b9\u5411\uff0c\u6f5c\u85cf\u7740\u4e0d\u5c11\u65b0\u7684\u53d1\u5c55\u673a\u9047\uff1a<\/p>\n

    \u3000\u3000\u9996\u5148\uff0c\u9664\u4e86\u5927\u5bb6\u719f\u77e5\u7684\u8c03\u8282\u8840\u7cd6\u548c\u4f53\u91cd\u7684\u4f5c\u7528\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u53d1\u73b0GLP-1R\u8fd8\u5bf9\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u3001\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u7b49\u591a\u79cd\u75be\u75c5\u6709\u6539\u5584\u4f5c\u7528\uff0c\u65b0\u7684\u4f5c\u7528\u673a\u5236\u548c\u65b0\u7684\u9002\u5e94\u75c7\u65b9\u5411\u8fd8\u6709\u5f88\u5927\u7684\u7814\u7a76\u7a7a\u95f4\uff0c\u9700\u8981\u5927\u91cf\u57fa\u7840\u7814\u7a76\u6765\u9a8c\u8bc1\uff0c\u5bf9\u9ad8\u8d28\u91cf\u5de5\u5177\u5316\u5408\u7269\u7684\u9700\u6c42\u4e5f\u4f1a\u6301\u7eed\u589e\u957f\u3002<\/p>\n

    \u3000\u3000\u5176\u6b21\uff0c\u5728\u521b\u65b0\u836f\u7814\u53d1\u9886\u57df\uff0c\u5c0f\u5206\u5b50GLP-1R\u6fc0\u52a8\u5242\u76f8\u6bd4\u591a\u80bd\u7c7b\u836f\u7269\uff0c\u5177\u5907\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u9ad8\u3001\u6210\u672c\u4f4e\u3001\u60a3\u8005\u4f9d\u4ece\u6027\u597d\u7b49\u4f18\u52bf\uff0c\u662f\u5f53\u4e0b\u65b0\u836f\u7814\u53d1\u7684\u70ed\u95e8\u65b9\u5411\uff0c\u4ece\u9776\u70b9\u9a8c\u8bc1\u5230\u5148\u5bfc\u5316\u5408\u7269\u7b5b\u9009\uff0c\u90fd\u9700\u8981\u9ad8\u8d28\u91cf\u7684\u5de5\u5177\u5316\u5408\u7269\u4f5c\u4e3a\u9633\u6027\u5bf9\u7167\uff0c\u8fd9\u4e5f\u7ed9\u4e0a\u6e38\u79d1\u7814\u8bd5\u5242\u884c\u4e1a\u5e26\u6765\u4e86\u7a33\u5b9a\u7684\u9700\u6c42\u3002<\/p>\n

    \u3000\u3000\u53e6\u5916\uff0c\u968f\u7740CRISPR\u57fa\u56e0\u7f16\u8f91\u3001\u5355\u7ec6\u80de\u6d4b\u5e8f\u7b49\u65b0\u6280\u672f\u4e0d\u65ad\u53d1\u5c55\uff0c\u7814\u7a76\u8005\u53ef\u4ee5\u4ece\u66f4\u7cbe\u7ec6\u7684\u5c42\u9762\u63a2\u7a76GLP-1R\u5728\u4e0d\u540c\u7ec6\u80de\u3001\u4e0d\u540c\u7ec4\u7ec7\u4e2d\u7684\u4f5c\u7528\u673a\u5236\uff0c\u8fd9\u4e9b\u65b0\u7684\u7814\u7a76\u65b9\u5411\u4e5f\u5bf9\u5de5\u5177\u5316\u5408\u7269\u7684\u8d28\u91cf\u63d0\u51fa\u4e86\u66f4\u9ad8\u7684\u8981\u6c42\uff0c\u63a8\u52a8\u6574\u4e2a\u884c\u4e1a\u5411\u66f4\u7cbe\u7ec6\u5316\u3001\u6807\u51c6\u5316\u7684\u65b9\u5411\u53d1\u5c55\u3002<\/p>\n

    \u3000\u3000\u5bf9\u4e8e\u79d1\u7814\u5de5\u4f5c\u8005\u6765\u8bf4\uff0c\u6293\u4f4f\u8fd9\u4e9b\u65b9\u5411\uff0c\u9009\u62e9\u5408\u9002\u7684\u5b9e\u9a8c\u5de5\u5177\uff0c\u5c31\u80fd\u66f4\u987a\u5229\u5730\u63a8\u8fdb\u8bfe\u9898\uff0c\u4ea7\u51fa\u9ad8\u8d28\u91cf\u7684\u7814\u7a76\u6210\u679c\u3002<\/p>\n

    \n

    GLP-1R\u6fc0\u52a8\u5242\u5de5\u5177\u5316\u5408\u7269\u4f7f\u7528\u9ad8\u9891FAQ\u89e3\u7b54<\/strong><\/h2>\n

    \u3000\u3000\u6211\u4eec\u6574\u7406\u4e86\u7528\u6237\u54a8\u8be2\u6700\u591a\u7684\u51e0\u4e2a\u95ee\u9898\uff0c\u5728\u8fd9\u91cc\u7edf\u4e00\u7ed9\u5927\u5bb6\u89e3\u7b54\uff1a<\/p>\n

    Q1\uff1aGLP\u20111R Agonist DMB\u53ef\u4ee5\u7528\u4e8e\u4eba\u4f53\u6216\u8005\u52a8\u7269\u4e34\u5e8a\u6cbb\u7597\u5417?<\/strong><\/h3>\n

    \u3000\u3000A\uff1a<\/strong>\u672c\u54c1\u4e13\u4e3a\u79d1\u7814\u5b9e\u9a8c\u4f7f\u7528\uff0c\u4e0d\u53ef\u7528\u4e8e\u4eba\u4f53\u53ca\u52a8\u7269\u4e34\u5e8a\u6cbb\u7597<\/strong>\uff0c\u4ec5\u53ef\u7528\u4e8e\u57fa\u7840\u79d1\u7814\u5b9e\u9a8c\u573a\u666f\u3002<\/p>\n

    \n

    Q2\uff1aGLP\u20111R Agonist DMB\u6709\u54ea\u4e9b\u89c4\u683c\u53ef\u4ee5\u9009\u62e9?<\/strong><\/h3>\n

    \u3000\u3000A\uff1a<\/strong>\u6709\u591a\u89c4\u683c\u73b0\u8d27\u53ef\u9009\uff0c\u5305\u542b1\u202fmg\u30015\u202fmg\u300110\u202fmg\u300125\u202fmg\u300150\u202fmg\u3001100\u202fmg<\/strong>\u56fa\u4f53\u7c89\u672b\uff0c\u540c\u65f6\u63d0\u4f9b1\u202fmL\u00d710\u202fmM DMSO\u9884\u5236\u6eb6\u6db2<\/strong>\uff0c\u9002\u914d\u4e0d\u540c\u89c4\u6a21\u7684\u5b9e\u9a8c\u9700\u6c42\u3002<\/p>\n

    \n

    Q3\uff1a\u56fa\u4f53\u7c89\u672b\u6eb6\u89e3\u7684\u65f6\u5019\u6709\u4ec0\u4e48\u6ce8\u610f\u4e8b\u9879\u5417?<\/strong><\/h3>\n

    \u3000\u3000A\uff1a<\/strong>\u8be5\u5316\u5408\u7269\u5728DMSO\u4e2d\u6eb6\u89e3\u5ea6\u53ef\u8fbe9.00 mg\/mL\uff0c\u914d\u5236\u65f6\u5efa\u8bae\u8d85\u58f0\u52a9\u6eb6<\/strong>\uff0c\u53ef\u4ee5\u5e2e\u52a9\u5316\u5408\u7269\u66f4\u5feb\u5145\u5206\u6eb6\u89e3\uff0c\u5982\u679c\u9700\u8981\u914d\u5236\u66f4\u9ad8\u6d53\u5ea6\u7684\u6eb6\u6db2\uff0c\u53ef\u4ee5\u9002\u5f53\u52a0\u6e29\u540e\u518d\u8d85\u58f0\u8f85\u52a9\uff0c\u5e2e\u52a9\u6eb6\u89e3\u3002<\/p>\n

    \n

    Q4\uff1aGLP\u20111R Agonist DMB\u7684\u4f5c\u7528\u673a\u5236\u660e\u786e\u5417?\u6709\u6ca1\u6709\u9a8c\u8bc1\u6570\u636e?<\/strong><\/h3>\n

    \u3000\u3000A\uff1a<\/strong>\u8be5\u5316\u5408\u7269\u7684\u4f5c\u7528\u673a\u5236\u5df2\u7ecf\u5f97\u5230\u660e\u786e\u9a8c\u8bc1\uff1a<\/p>\n

      \n
    1. \u4f53\u5916\u5b9e\u9a8c\u4e2d\uff0c\u5728100\u202fnM\u30011000\u202fnM\u6d53\u5ea6\u6761\u4ef6\u4e0b\uff0c\u80fd\u591f\u63d0\u5347\u91ce\u751f\u578b\u5c0f\u9f20\u80f0\u5c9b\u4e2dD\u2011(+)\u2011\u8461\u8404\u7cd6\u4ecb\u5bfc\u7684\u80f0\u5c9b\u7d20\u5206\u6ccc\uff0c\u8be5\u6548\u5e94\u5728GLP\u20111R\u57fa\u56e0\u6572\u9664\u5c0f\u9f20\u80f0\u5c9b\u4e2d\u6d88\u5931\uff0c\u8bc1\u660e\u4f5c\u7528\u4f9d\u8d56GLP\u20111\u53d7\u4f53\u901a\u8def\u3002<\/li>\n
    2. \u4f53\u5185\u52a8\u7269\u5b9e\u9a8c\u8868\u660e\uff0c5\u202f\u03bcmol\/kg\u7ed9\u836f\u5242\u91cf\u4e0b\uff0cDMB\u53ef\u6709\u6548\u964d\u4f4e\u5c0f\u9f20\u7a7a\u8179\u8840\u6d46\u8461\u8404\u7cd6\u6c34\u5e73\uff0c\u6d3b\u6027\u7ecf\u8fc7\u4f53\u5185\u9a8c\u8bc1\uff0c\u6570\u636e\u53ef\u9760\u3002<\/li>\n<\/ol>\n
      \n

      Q5\uff1a\u8fd0\u8f93\u548c\u50a8\u5b58\u6709\u4ec0\u4e48\u8981\u6c42\u5417?<\/strong><\/h3>\n

      \u3000\u3000A\uff1a<\/strong>\u8fd0\u8f93\u91c7\u7528\u84dd\u51b0\u6216\u5e38\u6e29\u8fd0\u8f93\uff0c\u7c89\u672b\u50a8\u5b58\u8981\u6c42\u4e3a-20\u2103\u907f\u5149\u4fdd\u5b58\uff0c\u6709\u6548\u671f3\u5e74<\/strong>;DMSO\u6bcd\u6db2\u5206\u88c5\u540e-80\u2103\u4fdd\u5b58\uff0c\u6709\u6548\u671f1\u5e74<\/strong>\uff0c\u5b9e\u9645\u50a8\u5b58\u6761\u4ef6\u4ee5\u968f\u8d27COA\u8bc1\u4e66\u4e3a\u51c6\u3002<\/p>\n

      \n

      \u4f01\u4e1a\u7efc\u5408\u627f\u63a5\u5b9e\u529b\u5c55\u793a<\/strong><\/h2>\n

      \u3000\u3000\u9676\u672f\u751f\u7269\u79d1\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8(TargetMol)\u56f4\u7ed5\u751f\u547d\u79d1\u5b66\u548c\u836f\u7269\u53d1\u73b0\u9886\u57df\uff0c\u4e3a\u5168\u7403\u521b\u65b0\u836f\u7814\u53d1\u63d0\u4f9b\u9ad8\u6548\u3001\u4fbf\u6377\u7684\u751f\u547d\u79d1\u5b66\u8bd5\u5242\uff0c\u9ad8\u901a\u91cf\u7b5b\u9009\u5316\u5408\u7269\u5e93\uff0c\u4eba\u5de5\u667a\u80fd\u836f\u7269\u7814\u53d1\u76f8\u5173\u7684\u7b5b\u9009\u5316\u5408\u7269\u548c\u6280\u672f\u670d\u52a1\uff0c\u76ee\u524d\u5df2\u7ecf\u6210\u957f\u4e3a\u7efc\u5408\u6027\u65b0\u836f\u7814\u53d1\u89e3\u51b3\u65b9\u6848\u670d\u52a1\u5546\uff0c\u6df1\u5ea6\u8d4b\u80fd\u5168\u7403\u9ad8\u6821\u3001\u79d1\u7814\u9662\u6240\u4e0e\u521b\u65b0\u836f\u4f01\u3002<\/p>\n

      \u3000\u3000TargetMol\u7684\u6838\u5fc3\u4f18\u52bf\u53ef\u4ee5\u603b\u7ed3\u4e3a\uff1a\u62e5\u6709\u591a\u5143\u5316\u5b8c\u6574\u4ea7\u54c1\u7ebf\u8986\u76d6\u836f\u7269\u7814\u53d1\u5168\u6d41\u7a0b\uff0c\u5168\u94fe\u8def\u6807\u51c6\u5316\u8d28\u63a7\u4f53\u7cfb\u4fdd\u969c\u4ea7\u54c1\u54c1\u8d28\uff0c\u5168\u89c4\u683c\u73b0\u8d27\u4f9b\u5e94\u53ef\u5feb\u901f\u53d1\u8d27\uff0c\u914d\u5957\u5b8c\u5584\u7684\u4e00\u7ad9\u5f0f\u6280\u672f\u670d\u52a1\uff0c\u52a9\u529b\u5168\u7403\u79d1\u7814\u4eba\u5458\u9ad8\u6548\u63a8\u8fdbGLP-1R\u76f8\u5173\u8bfe\u9898\u7814\u7a76\u3002<\/p>\n

      \u3000\u3000\u6211\u4eec\u7684\u5b9e\u529b\u6709\u591a\u91cd\u6743\u5a01\u4f50\u8bc1\uff1a<\/p>\n

        \n
      • \u54c1\u724c\u83b7\u5f97\u56fd\u9645\u6743\u5a01\u8ba4\u53ef\uff0c\u8363\u83b7\u5168\u7403\u751f\u547d\u79d1\u5b66\u5e73\u53f0CiteAb\u9881\u5e03\u7684Biochemical Supplier to Watch in 2023<\/strong>\u5956\u9879\uff0c2025\u5e74\u62ff\u4e0b\u5168\u7403\u79d1\u7814\u8bd5\u5242\u8bc4\u4ef7\u6570\u636e\u5e93Bioz\u6291\u5236\u5242\u54c1\u7c7b\u65b0\u9510\u4e4b\u661f\u4e13\u9879\u5956\u9879\uff0c\u54c1\u724c\u5b9e\u529b\u83b7\u5f97\u56fd\u9645\u79d1\u7814\u9886\u57df\u8ba4\u53ef\u3002<\/li>\n
      • \u56fd\u5185\u62e5\u6709\u591a\u9879\u5b98\u65b9\u8d44\u8d28\uff0c\u83b7\u8bc4\u9ad8\u65b0\u6280\u672f\u4f01\u4e1a\u3001\u4e13\u7cbe\u7279\u65b0\u5c0f\u5de8\u4eba\u4f01\u4e1a\u3001\u4e0a\u6d77\u5e02\u4e13\u7cbe\u7279\u65b0\u4f01\u4e1a\uff0c2026\u5e74\u5165\u9009\u7231\u91c7\u8d2d\u5e73\u53f0\u4e0a\u6d77\u9ad8\u54c1\u8d28\u91cd\u7ec4\u86cb\u767d\u5382\u5bb6\u699c\u5355\uff0c\u672c\u571f\u670d\u52a1\u80fd\u529b\u624e\u5b9e\u53ef\u9760\u3002<\/li>\n
      • \u5efa\u7acb\u4e86\u5168\u94fe\u8def\u6807\u51c6\u5316\u8d28\u63a7\u4f53\u7cfb\uff0c\u6301\u6709ISO9001\u8d28\u91cf\u7ba1\u7406\u4f53\u7cfb\u8ba4\u8bc1<\/strong>\u4e0eISO17025\u5b9e\u9a8c\u5ba4\u68c0\u6d4b\u8d44\u8d28\u8ba4\u8bc1<\/strong>\uff0c\u4ece\u539f\u6599\u5165\u5e93\u3001\u5408\u6210\u5236\u5907\u3001\u68c0\u6d4b\u5206\u88c5\u5230\u4ed3\u50a8\u7269\u6d41\u5168\u6d41\u7a0b\u6807\u51c6\u5316\u7ba1\u63a7\uff0c\u6bcf\u4e00\u6279\u6b21\u4ea7\u54c1\u5747\u53ef\u63d0\u4f9b\u5b8c\u6574\u68c0\u6d4b\u6570\u636e\uff0c\u4fdd\u969c\u5b9e\u9a8c\u7ed3\u679c\u53ef\u91cd\u590d\u3001\u7a33\u5b9a\u53ef\u9760\u3002<\/li>\n
      • \u5df2\u7ecf\u670d\u52a1\u4e8e\u5168\u7403\u4f17\u591a\u9ad8\u6821\u4e0e\u79d1\u7814\u673a\u6784\uff0c\u5305\u62ecHarvard University\u3001Weill Cornell Medicine\u3001Tsinghua University\u3001Peking University\uff0c\u4ee5\u53caU.S. Food and Drug Administration\u3001National Institutes of Health\u3001Chinese Academy of Medical Sciences\u7b49\u56fd\u9645\u6743\u5a01\u79d1\u7814\u4e0e\u533b\u7597\u673a\u6784\uff0c\u4ea7\u54c1\u5df2\u88ab15,000+ \u7bc7\u9ad8\u6c34\u5e73\u5b66\u672f\u6587\u732e\u5f15\u7528<\/strong>\uff0c\u5e7f\u6cdb\u53d1\u8868\u4e8eNature\u3001Science\u3001Cell\u7b49\u56fd\u9645\u6743\u5a01\u5b66\u672f\u671f\u520a\uff0c\u5f97\u5230\u5168\u7403\u79d1\u7814\u7528\u6237\u7684\u8ba4\u53ef\u3002<\/li>\n<\/ul>\n

        \u3000\u3000\u9488\u5bf9GLP\u20111R Agonist DMB\u8fd9\u6b3e\u4ea7\u54c1\uff0c\u6211\u4eec\u5df2\u7ecf\u5b8c\u6210\u4e86\u5b8c\u6574\u7684\u6d3b\u6027\u9a8c\u8bc1\u548c\u8d28\u91cf\u7ba1\u63a7\uff0c\u5168\u89c4\u683c\u73b0\u8d27\u50a8\u5907\uff0c\u4e0b\u5355\u540e\u53ef\u4ee5\u5feb\u901f\u53d1\u8d27\uff0c\u4e0d\u9700\u8981\u7b49\u5f85\u6f2b\u957f\u7684\u5b9a\u5236\u5408\u6210\u5468\u671f\uff0c\u9002\u5408\u9879\u76ee\u52a0\u6025\u63a8\u8fdb\u3002<\/p>\n

        \n

        \u9488\u5bf9GLP-1R\u79d1\u7814\u5b9e\u9a8c\u7684\u9488\u5bf9\u6027\u843d\u5730\u65b9\u6848<\/strong><\/h2>\n

        \u3000\u3000\u57fa\u4e8e\u591a\u5e74\u670d\u52a1\u79d1\u7814\u7528\u6237\u7684\u7ecf\u9a8c\uff0c\u6211\u4eec\u9488\u5bf9GLP-1R\u76f8\u5173\u79d1\u7814\u5b9e\u9a8c\uff0c\u6574\u7406\u4e86\u4e00\u5957\u53ef\u843d\u5730\u7684\u4f7f\u7528\u65b9\u6848\uff0c\u5e2e\u52a9\u5927\u5bb6\u66f4\u5feb\u4e0a\u624b\uff1a<\/p>\n

        \u3000\u3000\u7b2c\u4e00\u6b65\uff0c\u6839\u636e\u4f60\u7684\u5b9e\u9a8c\u89c4\u6a21\u9009\u62e9\u5408\u9002\u7684\u89c4\u683c\uff1a<\/p>\n

          \n
        • \u5982\u679c\u53ea\u662f\u505a\u521d\u6b65\u7684\u4f53\u5916\u7b5b\u9009\u6216\u8005\u9884\u5b9e\u9a8c\uff0c\u9009\u62e91 mg\u6216\u80055 mg\u56fa\u4f53\u7c89\u672b\uff0c\u6216\u8005\u76f4\u63a5\u9009\u62e91 mL\u00d710 mM DMSO\u9884\u5236\u6eb6\u6db2\u5c31\u53ef\u4ee5\u6ee1\u8db3\u9700\u6c42\uff0c\u9884\u5236\u6eb6\u6db2\u5f00\u7bb1\u5373\u53ef\u4f7f\u7528\uff0c\u7701\u53bb\u79f0\u91cf\u6eb6\u89e3\u7684\u6b65\u9aa4\uff0c\u9002\u5408\u5c0f\u5242\u91cf\u5feb\u901f\u5f00\u5c55\u5b9e\u9a8c\u3002<\/li>\n
        • \u5982\u679c\u9700\u8981\u5f00\u5c55\u591a\u6b21\u4f53\u5916\u5b9e\u9a8c\u6216\u8005\u5c0f\u5242\u91cf\u52a8\u7269\u5b9e\u9a8c\uff0c\u53ef\u4ee5\u9009\u62e910 mg\u523025 mg\u7684\u89c4\u683c\uff0c\u6027\u4ef7\u6bd4\u66f4\u9ad8\u3002<\/li>\n
        • \u5982\u679c\u9700\u8981\u5f00\u5c55\u5927\u6837\u672c\u52a8\u7269\u5b9e\u9a8c\u6216\u8005\u591a\u6b21\u91cd\u590d\u5b9e\u9a8c\uff0c\u53ef\u4ee5\u9009\u62e950 mg\u6216\u8005100 mg\u7684\u5927\u89c4\u683c\uff0c\u66f4\u7b26\u5408\u5b9e\u9a8c\u9700\u6c42\u3002<\/li>\n<\/ul>\n

          \u3000\u3000\u7b2c\u4e8c\u6b65\uff0c\u5316\u5408\u7269\u914d\u5236\u4e0e\u50a8\u5b58\uff1a<\/p>\n

            \n
          • \u9009\u62e9\u56fa\u4f53\u7c89\u672b\u7684\u7528\u6237\uff0c\u6839\u636e\u81ea\u5df1\u9700\u8981\u7684\u6d53\u5ea6\u79f0\u91cf\u5316\u5408\u7269\uff0c\u52a0\u5165DMSO\u540e\u8d85\u58f0\u52a9\u6eb6\uff0c\u914d\u5236\u597d\u7684\u6bcd\u6db2\u5efa\u8bae\u5206\u88c5\u6210\u5c0f\u4f53\u79ef\uff0c\u7f6e\u4e8e-80\u2103\u4fdd\u5b58\uff0c\u907f\u514d\u53cd\u590d\u51bb\u878d\u5bfc\u81f4\u6d3b\u6027\u4e0b\u964d\u3002<\/li>\n
          • \u9009\u62e9\u9884\u5236\u6eb6\u6db2\u7684\u7528\u6237\uff0c\u6536\u5230\u540e\u76f4\u63a5\u5206\u88c5\u51bb\u5b58\u5c31\u53ef\u4ee5\u4f7f\u7528\uff0c\u975e\u5e38\u65b9\u4fbf\u3002<\/li>\n<\/ul>\n

            \u3000\u3000\u7b2c\u4e09\u6b65\uff0c\u4e0d\u540c\u5b9e\u9a8c\u7684\u7ed9\u836f\u53c2\u8003\uff1a<\/p>\n

              \n
            • \u4f53\u5916cAMP\u4fe1\u53f7\u68c0\u6d4b\u5b9e\u9a8c<\/strong>\uff1a\u53ef\u4ee5\u53c2\u8003\u5df2\u9a8c\u8bc1\u7684\u6d3b\u6027\u6570\u636e\uff0c\u8bbe\u7f6e1 nM\u52301000 nM\u7684\u6d53\u5ea6\u68af\u5ea6\uff0c\u68c0\u6d4b\u5316\u5408\u7269\u5bf9GLP-1R\u540ecAMP\u6c34\u5e73\u7684\u5f71\u54cd\uff0c\u8be5\u5316\u5408\u7269\u7684EC50\u4e3a101 nM\uff0c\u53ef\u4ee5\u5c06\u8fd9\u4e2a\u6d53\u5ea6\u4f5c\u4e3a\u4e2d\u5fc3\u8bbe\u7f6e\u68af\u5ea6\u3002<\/li>\n
            • \u79bb\u4f53\u80f0\u5c9b\u5b75\u80b2\u5b9e\u9a8c<\/strong>\uff1a\u53ef\u4ee5\u9009\u62e9100 nM\u548c1000 nM\u4e24\u4e2a\u6d53\u5ea6\uff0c\u9a8c\u8bc1\u8461\u8404\u7cd6\u4ecb\u5bfc\u7684\u80f0\u5c9b\u7d20\u5206\u6ccc\u4fc3\u8fdb\u6548\u5e94\uff0c\u5df2\u7ecf\u6709\u6587\u732e\u9a8c\u8bc1\u8fd9\u4e24\u4e2a\u6d53\u5ea6\u53ef\u4ee5\u5f97\u5230\u7a33\u5b9a\u7684\u9633\u6027\u7ed3\u679c\u3002<\/li>\n
            • \u5c0f\u9f20\u4f53\u5185\u964d\u8840\u7cd6\u5b9e\u9a8c<\/strong>\uff1a\u53c2\u8003\u5df2\u9a8c\u8bc1\u7684\u7ed9\u836f\u5242\u91cf\uff0c5 \u03bcmol\/kg\u7684\u7ed9\u836f\u5242\u91cf\u5c31\u53ef\u4ee5\u6709\u6548\u964d\u4f4e\u5c0f\u9f20\u7a7a\u8179\u8840\u6d46\u8461\u8404\u7cd6\u6c34\u5e73\uff0c\u53ef\u4ee5\u6839\u636e\u4f60\u7684\u5b9e\u9a8c\u8bbe\u8ba1\u8c03\u6574\u5242\u91cf\u3002<\/li>\n<\/ul>\n

              \u3000\u3000\u6574\u4e2a\u5b9e\u9a8c\u8fc7\u7a0b\u4e2d\uff0c\u5982\u679c\u6709\u4efb\u4f55\u5173\u4e8e\u6eb6\u89e3\u5ea6\u914d\u5236\u3001\u50a8\u5b58\u4f7f\u7528\u7684\u95ee\u9898\uff0c\u90fd\u53ef\u4ee5\u54a8\u8be2\u6211\u4eec\u7684\u6280\u672f\u56e2\u961f\uff0c\u6211\u4eec\u4f1a\u63d0\u4f9b\u5feb\u901f\u7684\u6280\u672f\u652f\u6301\uff0c\u5e2e\u52a9\u4f60\u89e3\u51b3\u95ee\u9898\u3002<\/p>\n

              \n

              \u4e0d\u540c\u5b9e\u9a8c\u573a\u666f\u7684\u9009\u578b\u68b3\u7406\u603b\u7ed3<\/strong><\/h2>\n

              \u3000\u3000\u6700\u540e\uff0c\u6211\u4eec\u9488\u5bf9\u4e0d\u540c\u7684\u5e38\u89c1\u5b9e\u9a8c\u573a\u666f\uff0c\u7ed9\u5927\u5bb6\u505a\u4e00\u4e2a\u7b80\u5355\u7684\u9009\u578b\u603b\u7ed3\uff0c\u65b9\u4fbf\u5927\u5bb6\u5feb\u901f\u9009\u62e9\uff1a<\/p>\n

                \n
              • \n

                \u573a\u666f\u4e00\uff1a\u9884\u5b9e\u9a8c\/\u5c0f\u6837\u672c\u7ec6\u80de\u5b9e\u9a8c\uff0c\u8ffd\u6c42\u4fbf\u6377\u6027<\/strong>
                \n\u63a8\u8350\u9009\u62e9\uff1a1 mL\u00d710 mM DMSO\u9884\u5236\u6eb6\u6db2<\/strong>
                \n\u4f18\u52bf\uff1a\u7701\u53bb\u56fa\u4f53\u79f0\u91cf\u6eb6\u89e3\u7684\u6b65\u9aa4\uff0c\u5f00\u7bb1\u5373\u53ef\u76f4\u63a5\u7528\u4e8e\u7ec6\u80de\u7ed9\u836f\uff0c\u89c4\u907f\u79f0\u91cf\u635f\u8017\u4e0e\u6eb6\u89e3\u96be\u9898\uff0c\u9002\u5408\u5c0f\u6837\u672c\u5feb\u901f\u5f00\u5c55\u5b9e\u9a8c\u3002<\/p>\n<\/li>\n

              • \n

                \u573a\u666f\u4e8c\uff1a\u5e38\u89c4\u4f53\u5916\u7ec6\u80de\u5b9e\u9a8c\/\u673a\u5236\u9a8c\u8bc1<\/strong>
                \n\u63a8\u8350\u9009\u62e9\uff1a1 mg-10 mg\u56fa\u4f53\u7c89\u672b<\/strong>
                \n\u4f18\u52bf\uff1a\u6027\u4ef7\u6bd4\u9ad8\uff0c\u53ef\u4ee5\u6839\u636e\u81ea\u5df1\u7684\u9700\u6c42\u7075\u6d3b\u914d\u5236\u4e0d\u540c\u6d53\u5ea6\u7684\u5de5\u4f5c\u6db2\uff0c\u6ee1\u8db3\u591a\u6b21\u4f53\u5916\u5b9e\u9a8c\u7684\u9700\u6c42\u3002<\/p>\n<\/li>\n

              • \n

                \u573a\u666f\u4e09\uff1a\u79bb\u4f53\u80f0\u5c9b\u5b75\u80b2\/\u5c0f\u578b\u52a8\u7269\u9884\u5b9e\u9a8c<\/strong>
                \n\u63a8\u8350\u9009\u62e9\uff1a25 mg-50 mg\u56fa\u4f53\u7c89\u672b<\/strong>
                \n\u4f18\u52bf\uff1a\u4e00\u6b21\u91c7\u8d2d\u53ef\u4ee5\u6ee1\u8db3\u591a\u4e2a\u5b9e\u9a8c\u7684\u9700\u6c42\uff0c\u4e0d\u9700\u8981\u591a\u6b21\u4e0b\u5355\u91c7\u8d2d\uff0c\u8282\u7701\u65f6\u95f4\u6210\u672c\u3002<\/p>\n<\/li>\n

              • \n

                \u573a\u666f\u56db\uff1a\u5927\u6837\u672c\u52a8\u7269\u5b9e\u9a8c\/\u957f\u671f\u8bfe\u9898\u7814\u7a76<\/strong>
                \n\u63a8\u8350\u9009\u62e9\uff1a100 mg\u56fa\u4f53\u7c89\u672b<\/strong>
                \n\u4f18\u52bf\uff1a\u5927\u89c4\u683c\u5305\u88c5\u6027\u4ef7\u6bd4\u66f4\u9ad8\uff0c\u9002\u5408\u957f\u671f\u8bfe\u9898\u591a\u6b21\u5b9e\u9a8c\u4f7f\u7528\uff0c\u7c89\u672b-20\u2103\u907f\u5149\u53ef\u4ee5\u4fdd\u5b583\u5e74\uff0c\u6d3b\u6027\u7a33\u5b9a\uff0c\u957f\u671f\u4f7f\u7528\u4e5f\u6ca1\u6709\u95ee\u9898\u3002<\/p>\n<\/li>\n<\/ul>\n

                \u3000\u3000GLP-1R\u76f8\u5173\u7684\u57fa\u7840\u7814\u7a76\u548c\u65b0\u836f\u7b5b\u9009\uff0c\u79bb\u4e0d\u5f00\u4e00\u6b3e\u9ad8\u8d28\u91cf\u7684\u5de5\u5177\u5316\u5408\u7269\uff0cTargetMol\u4f5c\u4e3a\u5168\u7403\u77e5\u540d\u7684\u79d1\u7814\u8bd5\u5242\u54c1\u724c\uff0c \u624b\u673a\uff1a17321231762 \u63a8\u51fa\u7684GLP\u20111R Agonist DMB\u76f8\u6bd4\u591a\u80bd\u7c7bGLP-1R\u6fc0\u52a8\u5242\uff0c\u5177\u5907\u7ed3\u6784\u7a33\u5b9a\u3001\u4fbf\u4e8e\u7ed9\u836f\u3001\u9002\u5408\u4f53\u5916\u7ec6\u80de\u4e0e\u4f53\u5185\u52a8\u7269\u6a21\u578b\u7814\u7a76\u7b49\u7a81\u51fa\u4f18\u52bf\uff0c\u52a9\u529b\u79d1\u7814\u4eba\u5458\u5f00\u5c55\u7cd6\u4ee3\u8c22\u3001\u80f0\u5c9b\u529f\u80fd\u53ca\u76f8\u5173\u9776\u70b9\u673a\u5236\u7814\u7a76\u3002\u5982\u679c\u4f60\u6b63\u5728\u5bfb\u627e\u4e00\u6b3e\u6d3b\u6027\u660e\u786e\u3001\u8d28\u91cf\u53ef\u9760\u7684GLP-1R\u5c0f\u5206\u5b50\u6fc0\u52a8\u5242\uff0c\u4e0d\u59a8\u9009\u62e9\u8fd9\u6b3e\u73b0\u8d27\u4ea7\u54c1\uff0c\u5168\u6279\u6b21COA\u9f50\u5168\uff0c\u652f\u6301NMR\u548cHPLC\u8d28\u68c0\u62a5\u544a\uff0c\u4ece\u6e90\u5934\u4e3a\u4f60\u7684\u5b9e\u9a8c\u7ed3\u679c\u4fdd\u9a7e\u62a4\u822a\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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