{"id":108097,"date":"2026-08-07T04:11:45","date_gmt":"2026-08-06T20:11:45","guid":{"rendered":"https:\/\/ww.xysww.com\/?p=108097"},"modified":"2026-08-07T04:11:45","modified_gmt":"2026-08-06T20:11:45","slug":"%e5%85%a8%e7%90%83ripretinib%e6%9c%8d%e5%8a%a1%e5%95%86%e4%bb%b7%e6%a0%bc%e5%93%aa%e5%ae%b6%e4%bd%8e-%e8%a1%8c%e4%b8%9a%e5%85%a8%e6%99%af%e5%88%86%e6%9e%90","status":"publish","type":"post","link":"https:\/\/ww.xysww.com\/?p=108097","title":{"rendered":"\u5168\u7403Ripretinib\u670d\u52a1\u5546\u4ef7\u683c\u54ea\u5bb6\u4f4e \u884c\u4e1a\u5168\u666f\u5206\u6790"},"content":{"rendered":"

\u5168\u7403Ripretinib\u670d\u52a1\u5546\u4ef7\u683c\u54ea\u5bb6\u4f4e \u884c\u4e1a\u5168\u666f\u5206\u6790<\/h2>\n

\u5f00\u7bc7\u884c\u4e1a\u75db\u70b9\uff1a\u79d1\u7814\u91c7\u8d2d\u4e2d\u7684\u56db\u5927\u5e38\u89c1\u9677\u9631<\/h3>\n

\u3000\u3000\u5728\u751f\u547d\u79d1\u5b66\u548c\u836f\u7269\u7814\u53d1\u9886\u57df\uff0c\u9009\u62e9\u4e00\u6b3e\u9ad8\u8d28\u91cf\u7684\u79d1\u7814\u8bd5\u5242\uff0c\u5c24\u5176\u662f\u50cfRipretinib<\/strong>(\u745e\u666e\u66ff\u5c3c)\u8fd9\u7c7b\u5173\u952e\u7684\u6fc0\u9176\u6291\u5236\u5242\uff0c\u5f80\u5f80\u8ba9\u79d1\u7814\u4eba\u5458\u5934\u75bc\u4e0d\u5df2\u3002\u9762\u5bf9\u5e02\u573a\u4e0a\u4f17\u591a\u7684\u4f9b\u5e94\u5546\uff0c\u4ece\u9009\u578b\u5230\u6700\u7ec8\u4ea4\u4ed8\uff0c\u6bcf\u4e00\u4e2a\u73af\u8282\u90fd\u53ef\u80fd\u6697\u85cf\u98ce\u9669\u3002\u4ee5\u4e0b\u662f\u79d1\u7814\u4eba\u5458\u5728\u9009\u8d2dRipretinib<\/strong>\u65f6\u6700\u5e38\u9047\u5230\u7684\u56db\u5927\u96be\u9898\uff0c\u8fd9\u4e9b\u75db\u70b9\u76f4\u63a5\u5173\u7cfb\u5230\u5b9e\u9a8c\u7684\u6210\u8d25\u3001\u6570\u636e\u7684\u53ef\u9760\u6027\u4ee5\u53ca\u9879\u76ee\u8fdb\u5ea6\u7684\u5feb\u6162\u3002<\/p>\n

<\/p>\n

\u3000\u3000\u7b2c\u4e00\uff0c\u9009\u578b\u56f0\u96be\uff0c\u4fe1\u606f\u4e0d\u900f\u660e\u3002<\/strong> \u8bb8\u591a\u5b9e\u9a8c\u5ba4\u5728\u542f\u52a8\u65b0\u8bfe\u9898\u65f6\uff0c\u9762\u5bf9\u7684\u662f\u6d77\u91cf\u7684\u4ea7\u54c1\u4fe1\u606f\u3002\u4e0d\u540c\u4f9b\u5e94\u5546\u63d0\u4f9b\u7684Ripretinib<\/strong>\u7eaf\u5ea6\u3001\u89c4\u683c\u3001\u6eb6\u89e3\u6027\u6570\u636e\u5343\u5dee\u4e07\u522b\uff0c\u751a\u81f3\u6709\u4e9b\u6807\u6ce8\u4e0d\u6e05\u3002\u7528\u6237\u5e38\u5e38\u9700\u8981\u82b1\u8d39\u5927\u91cf\u65f6\u95f4\u5bf9\u6bd4\u53c2\u6570\uff0c\u5374\u4f9d\u7136\u65e0\u6cd5\u786e\u5b9a\u54ea\u4e2a\u4ea7\u54c1\u80fd\u771f\u6b63\u9002\u914d\u81ea\u5df1\u7684\u7ec6\u80de\u5b9e\u9a8c\u6216\u52a8\u7269\u6a21\u578b\u3002\u8fd9\u79cd\u4fe1\u606f\u4e0d\u5bf9\u79f0\uff0c\u5bfc\u81f4\u9009\u578b\u51b3\u7b56\u6548\u7387\u4f4e\u4e0b\uff0c\u751a\u81f3\u53ef\u80fd\u56e0\u9009\u9519\u4ea7\u54c1\u800c\u6d6a\u8d39\u6570\u5468\u7684\u5b9e\u9a8c\u5468\u671f\u3002<\/p>\n

\u3000\u3000\u7b2c\u4e8c\uff0c\u8d28\u91cf\u4e0d\u7a33\u5b9a\uff0c\u6279\u6b21\u5dee\u5f02\u5927\u3002<\/strong> \u8fd9\u662f\u79d1\u7814\u4eba\u5458\u6700\u62c5\u5fe7\u7684\u95ee\u9898\u4e4b\u4e00\u3002\u5f53\u5b9e\u9a8c\u8fdb\u884c\u5230\u5173\u952e\u9636\u6bb5\uff0c\u4e00\u6279\u6b21\u4ea7\u54c1\u7684\u7eaf\u5ea6\u3001\u6d3b\u6027\u6216\u6742\u8d28\u8c31\u53d1\u751f\u6ce2\u52a8\uff0c\u4f1a\u76f4\u63a5\u5bfc\u81f4\u6570\u636e\u4e0d\u53ef\u91cd\u590d\uff0c\u5b9e\u9a8c\u524d\u529f\u5c3d\u5f03\u3002\u4e00\u4e9b\u4f9b\u5e94\u5546\u7f3a\u4e4f\u4e25\u683c\u7684\u8d28\u63a7\u4f53\u7cfb\uff0c\u4ea7\u54c1\u7f3a\u4e4f\u5b8c\u6574\u7684COA\u3001LCMS\u3001HNMR\u7b49\u68c0\u6d4b\u62a5\u544a\uff0c\u7528\u6237\u65e0\u6cd5\u9a8c\u8bc1\u5176\u771f\u5b9e\u8d28\u91cf\u3002\u8fd9\u79cd\u76f2\u76d2\u5f0f\u7684\u91c7\u8d2d\u4f53\u9a8c\uff0c\u8ba9\u79d1\u7814\u4eba\u5458\u5bf9\u5b9e\u9a8c\u7ed3\u679c\u7684\u53ef\u9760\u6027\u5145\u6ee1\u7591\u8651\u3002<\/p>\n

\u3000\u3000\u7b2c\u4e09\uff0c\u6536\u8d39\u4e0d\u900f\u660e\uff0c\u4ef7\u683c\u4f53\u7cfb\u6df7\u4e71\u3002<\/strong> \u540c\u6837\u7684Ripretinib<\/strong>\uff0c\u5728\u4e0d\u540c\u6e20\u9053\u7684\u4ef7\u683c\u53ef\u80fd\u76f8\u5dee\u6570\u500d\u3002\u90e8\u5206\u4f9b\u5e94\u5546\u6807\u4ef7\u4f4e\uff0c\u4f46\u540e\u7eed\u4f1a\u6536\u53d6\u9ad8\u6602\u7684\u8fd0\u8d39\u3001\u51b7\u94fe\u8d39\u6216\u5305\u88c5\u8d39;\u6709\u4e9b\u5219\u865a\u6807\u9ad8\u4ef7\uff0c\u5229\u7528\u4fe1\u606f\u5dee\u725f\u5229\u3002\u7528\u6237\u96be\u4ee5\u5224\u65ad\u4e00\u4e2a\u4ea7\u54c1\u7684\u771f\u5b9e\u5e02\u573a\u4ef7\u503c\uff0c\u66f4\u65e0\u6cd5\u5728\u9884\u7b97\u6709\u9650\u7684\u60c5\u51b5\u4e0b\uff0c\u627e\u5230\u6027\u4ef7\u6bd4\u7684\u7a33\u5b9a\u4f9b\u8d27\u6e90\u3002\u8fd9\u79cd\u4ef7\u683c\u4e0d\u900f\u660e\uff0c\u8ba9\u9884\u7b97\u672c\u5c31\u7d27\u5f20\u7684\u8bfe\u9898\u7ec4\u96ea\u4e0a\u52a0\u971c\u3002<\/p>\n

\u3000\u3000\u7b2c\u56db\uff0c\u552e\u540e\u65e0\u4fdd\u969c\uff0c\u6280\u672f\u652f\u6301\u7f3a\u5931\u3002<\/strong> \u5b9e\u9a8c\u8fc7\u7a0b\u4e2d\uff0c\u4ea7\u54c1\u6eb6\u89e3\u3001\u7ed9\u836f\u65b9\u6848\u3001\u50a8\u5b58\u6761\u4ef6\u7b49\u95ee\u9898\u5c42\u51fa\u4e0d\u7a77\u3002\u5f88\u591a\u4f9b\u5e94\u5546\u53ea\u8d1f\u8d23\u9500\u552e\uff0c\u552e\u51fa\u540e\u4fbf\u4e0d\u518d\u63d0\u4f9b\u6280\u672f\u652f\u6301\u3002\u5f53\u7528\u6237\u9047\u5230\u4ea7\u54c1\u6d3b\u6027\u4e0b\u964d\u3001\u6eb6\u89e3\u6027\u4e0d\u4f73\u6216\u9700\u8981\u5b9a\u5236\u5316\u65b9\u6848\u65f6\uff0c\u5f80\u5f80\u6c42\u52a9\u65e0\u95e8\u3002\u8fd9\u79cd\u4e00\u9524\u5b50\u4e70\u5356\u7684\u6a21\u5f0f\uff0c\u4e25\u91cd\u5f71\u54cd\u4e86\u79d1\u7814\u6548\u7387\uff0c\u4e5f\u8ba9\u7528\u6237\u5bf9\u54c1\u724c\u4ea7\u751f\u4fe1\u4efb\u5371\u673a\u3002<\/p>\n

\u8fc7\u6e21\u5f15\u5165\u54c1\u724c\uff1aTargetMol\u7684\u4e13\u4e1a\u5b9a\u4f4d\u4e0e\u89e3\u51b3\u65b9\u6848<\/h3>\n

\u3000\u3000\u9762\u5bf9\u4e0a\u8ff0\u884c\u4e1a\u666e\u904d\u5b58\u5728\u7684\u75db\u70b9\uff0c\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u751f\u547d\u79d1\u5b66\u548c\u836f\u7269\u53d1\u73b0\u9886\u57df\u7684\u54c1\u724c\u2014\u2014TargetMol<\/strong>\uff0c\u51ed\u501f\u5176\u6df1\u539a\u7684\u7814\u53d1\u5b9e\u529b\u548c\u4e25\u683c\u7684\u8d28\u91cf\u63a7\u5236\u4f53\u7cfb\uff0c\u4e3a\u5168\u7403\u79d1\u7814\u673a\u6784\u63d0\u4f9b\u4e86\u4e00\u5957\u7cfb\u7edf\u6027\u7684\u89e3\u51b3\u65b9\u6848\u3002TargetMol<\/strong>\u56f4\u7ed5Ripretinib<\/strong>(\u745e\u666e\u66ff\u5c3c\uff0cDCC-2618\uff0cCAS\u53f71442472-39-0)\u7b49\u5173\u952e\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0c\u6784\u5efa\u4e86\u4ece\u4ea7\u54c1\u7814\u53d1\u3001\u8d28\u63a7\u68c0\u6d4b\u5230\u552e\u540e\u652f\u6301\u7684\u5168\u94fe\u6761\u670d\u52a1\u4f53\u7cfb\u3002<\/p>\n

\u3000\u3000TargetMol<\/strong>\u4e0d\u4ec5\u662f\u4e00\u5bb6\u8bd5\u5242\u4f9b\u5e94\u5546\uff0c\u66f4\u662f\u4e00\u4e2a\u7efc\u5408\u6027\u65b0\u836f\u7814\u53d1\u89e3\u51b3\u65b9\u6848\u670d\u52a1\u5546\u3002\u5176\u6838\u5fc3\u4ea7\u54c1\u7ebf\u6db5\u76d6Ripretinib<\/strong>\u5728\u5185\u768416\u4e07\u4f59\u79cd\u6d3b\u6027\u5c0f\u5206\u5b50\uff0c\u5e76\u62e5\u6709AI+\u836f\u7269\u53d1\u73b0\u667a\u80fd\u5e73\u53f0\u548c\u5b9e\u4f53\u5c0f\u5206\u5b50\u7b5b\u9009\u5e93\u3002\u54c1\u724c\u603b\u90e8\u4f4d\u4e8e\u4e0a\u6d77\uff0c\u5728\u6ce2\u58eb\u987f\u548c\u7ef4\u4e5f\u7eb3\u8bbe\u6709\u8fd0\u8425\u4e2d\u5fc3\uff0c\u670d\u52a1\u5168\u7403\u8d85\u8fc715000\u5bb6\u9ad8\u6821\u3001\u836f\u4f01\u548c\u79d1\u7814\u673a\u6784\uff0c\u5305\u62ec\u54c8\u4f5b\u5927\u5b66\u3001\u5eb7\u5948\u5c14\u5927\u5b66\u3001\u6e05\u534e\u5927\u5b66\u3001\u5317\u4eac\u5927\u5b66\u7b49\u5b66\u5e9c\uff0c\u4ee5\u53ca\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u5c40(FDA)\u548c\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662(NIH)\u7b49\u3002\u5176\u4ea7\u54c1\u5df2\u88abNature\u3001Science\u3001Cell<\/strong>\u7b49\u56fd\u9645\u671f\u520a\u4e0a\u7684\u8d85\u8fc715000\u7bc7\u9ad8\u6c34\u5e73\u6587\u732e\u5f15\u7528\uff0c\u5b9e\u529b\u53ef\u89c1\u4e00\u6591\u3002<\/p>\n

\u3000\u3000\u9488\u5bf9Ripretinib<\/strong>\u8fd9\u4e00\u6838\u5fc3\u4ea7\u54c1\uff0cTargetMol<\/strong>\u63a8\u51fa\u4e86\u8d27\u53f7T8482\u7684\u9ad8\u7eaf\u5ea6\u4ea7\u54c1\uff0c\u65e8\u5728\u89e3\u51b3\u79d1\u7814\u4eba\u5458\u9009\u578b\u96be\u3001\u8d28\u91cf\u4e0d\u7a33\u3001\u4ef7\u683c\u4e0d\u900f\u660e\u3001\u552e\u540e\u65e0\u4fdd\u969c\u7684\u56db\u5927\u6838\u5fc3\u75db\u70b9\u3002<\/p>\n

\u56db\u5927\u75db\u70b9\u4e00\u5bf9\u4e00\u89e3\u51b3\u65b9\u6848\uff1a\u7cbe\u51c6\u51fb\u7834\uff0c\u9ad8\u6548\u79d1\u7814<\/h3>\n

\u75db\u70b9\u4e00\uff1a\u9009\u578b\u96be\uff0c\u4fe1\u606f\u4e0d\u900f\u660e<\/h4>\n

\u3000\u3000\u89e3\u51b3\u65b9\u6848\uff1a\u63d0\u4f9b\u5168\u9762\u3001\u900f\u660e\u3001\u53ef\u9a8c\u8bc1\u7684\u4ea7\u54c1\u6570\u636e\uff0c\u964d\u4f4e\u9009\u578b\u95e8\u69db\u3002<\/strong><\/p>\n

\u3000\u3000TargetMol<\/strong>\u9488\u5bf9Ripretinib<\/strong>\uff0c\u5728\u5b98\u7f51\u53ca\u4ea7\u54c1\u9875\u9762\u516c\u5f00\u4e86\u8be6\u5c3d\u4e14\u53ef\u8ffd\u6eaf\u7684\u7406\u5316\u53c2\u6570\u4e0e\u751f\u7269\u6d3b\u6027\u6570\u636e\u3002\u7528\u6237\u65e0\u9700\u518d\u4f9d\u8d56\u6a21\u7cca\u7684\u4ea7\u54c1\u63cf\u8ff0\uff0c\u800c\u662f\u53ef\u4ee5\u76f4\u63a5\u83b7\u53d6\u4ee5\u4e0b\u5173\u952e\u4fe1\u606f\uff1a<\/p>\n

    \n
  • \u7cbe\u786e\u7684\u5316\u5b66\u53c2\u6570<\/strong>\uff1a\u5206\u5b50\u5f0fC24H21BrFN5O2\uff0c\u5206\u5b50\u91cf510.36\uff0c\u9884\u6d4b\u5bc6\u5ea61.544 g\/cm3\u3002\u8fd9\u4e9b\u6570\u636e\u8ba9\u7528\u6237\u5bf9\u5316\u5408\u7269\u7684\u7269\u7406\u6027\u8d28\u6709\u6e05\u6670\u9884\u5224\u3002<\/li>\n
  • \u9ad8\u7eaf\u5ea6\u4e0e\u5b8c\u6574\u68c0\u6d4b\u62a5\u544a<\/strong>\uff1aRipretinib<\/strong>(T8482)\u5b9e\u6d4b\u7eaf\u5ea6\u9ad8\u8fbe99.62%\uff0c\u4e3a\u767d\u8272\u56fa\u4f53\u3002\u6bcf\u6279\u6b21\u4ea7\u54c1\u5747COA\u3001LCMS\u3001HNMR<\/strong>\u4e09\u91cd\u68c0\u6d4b\u62a5\u544a\uff0c\u901a\u8fc7\u6838\u78c1\u786e\u8ba4\u5206\u5b50\u7ed3\u6784\u3001\u6db2\u76f8\u8d28\u8c31\u9501\u5b9a\u7eaf\u5ea6\uff0c\u5f7b\u5e95\u675c\u7edd\u4e86\u6742\u8d28\u5e72\u6270\u7684\u53ef\u80fd\u6027\u3002\u7528\u6237\u53ef\u968f\u65f6\u9a8c\u8bc1\uff0c\u786e\u4fdd\u6570\u636e\u771f\u5b9e\u53ef\u9760\u3002<\/li>\n
  • \u660e\u786e\u7684\u751f\u7269\u6d3b\u6027\u6570\u636e<\/strong>\uff1a\u4ea7\u54c1\u9875\u9762\u6e05\u6670\u6807\u6ce8\u4e86Ripretinib<\/strong>\u5bf9\u91ce\u751f\u578bKIT\u3001T670I\u7a81\u53d8\u4f53\u7684IC50\u503c(\u5206\u522b\u4e3a13.0 nM\u30019.2 nM)\uff0c\u4ee5\u53ca\u5bf9FLT3\u3001PDGFR\u03b2\u3001VEGFR2\u7b49\u9776\u70b9\u7684\u6291\u5236\u6d3b\u6027\uff0c\u5e76\u660e\u786e\u6307\u51fa\u5176\u5bf9KIT D816V\u3001PDGFR\u03b1 D842V\u7a81\u53d8\u6291\u5236\u6d3b\u6027\u504f\u5f31\u3002\u8fd9\u79cd\u9776\u70b9\u9009\u62e9\u6027\u6e05\u6670\u7684\u6807\u6ce8\uff0c\u5e2e\u52a9\u7528\u6237\u5feb\u901f\u5224\u65ad\u8be5\u4ea7\u54c1\u662f\u5426\u9002\u914d\u81ea\u5df1\u7684\u7814\u7a76\u6a21\u578b\uff0c\u6781\u5927\u63d0\u5347\u4e86\u9009\u578b\u6548\u7387\u3002<\/li>\n
  • \u89c4\u683c\u4e0e\u5f62\u6001\u9009\u62e9\u591a\u6837<\/strong>\uff1a\u63d0\u4f9b\u7c89\u672b\u89c4\u683c<\/strong>(1mg\u81f3200mg\u68af\u5ea6)\u548c\u9884\u523610 mM DMSO\u6eb6\u6db2<\/strong>(1mL\u72ec\u7acb\u5305\u88c5)\u4e24\u79cd\u5f62\u6001\u3002\u7528\u6237\u53ef\u6839\u636e\u5b9e\u9a8c\u89c4\u6a21(\u9884\u5b9e\u9a8c\u3001\u7ec6\u80de\u5b9e\u9a8c\u3001\u52a8\u7269\u9020\u6a21)\u7075\u6d3b\u9009\u62e9\uff0c\u65e0\u9700\u81ea\u884c\u6eb6\u89e3\uff0c\u5927\u5e45\u8282\u7701\u65f6\u95f4\u3002<\/li>\n<\/ul>\n

    \u75db\u70b9\u4e8c\uff1a\u8d28\u91cf\u4e0d\u7a33\u5b9a\uff0c\u6279\u6b21\u5dee\u5f02\u5927<\/h4>\n

    \u3000\u3000\u89e3\u51b3\u65b9\u6848\uff1a\u6784\u5efa\u5168\u94fe\u8def\u6807\u51c6\u5316\u8d28\u63a7\u4f53\u7cfb\uff0c\u786e\u4fdd\u6279\u6b21\u95f4\u9ad8\u5ea6\u4e00\u81f4\u3002<\/strong><\/p>\n

    \u3000\u3000TargetMol<\/strong>\u5c06\u8d28\u91cf\u63a7\u5236\u89c6\u4e3a\u4ea7\u54c1\u751f\u547d\u7ebf\uff0c\u5176Ripretinib<\/strong>\u4ea7\u54c1\u4ece\u539f\u6599\u5165\u5e93\u5230\u6210\u54c1\u51fa\u5e93\uff0c\u7ecf\u5386\u4e86\u4e25\u683c\u7684\u6807\u51c6\u5316\u6d41\u7a0b\uff0c\u786e\u4fdd\u6bcf\u4e00\u6279\u6b21\u4ea7\u54c1\u5747\u5177\u5907\u9ad8\u5ea6\u7a33\u5b9a\u6027\u548c\u53ef\u91cd\u590d\u6027\u3002<\/p>\n

      \n
    • \u53cc\u91cd\u6743\u5a01\u8ba4\u8bc1<\/strong>\uff1a\u516c\u53f8\u6301\u6709ISO9001\u8d28\u91cf\u7ba1\u7406\u4f53\u7cfb\u8ba4\u8bc1<\/strong>\u4e0eISO17025\u5b9e\u9a8c\u5ba4\u68c0\u6d4b\u8d44\u8d28\u8ba4\u8bc1<\/strong>\uff0c\u4ece\u5236\u5ea6\u4e0a\u4fdd\u969c\u4e86\u4ea7\u54c1\u4ece\u5408\u6210\u3001\u5236\u5907\u3001\u68c0\u6d4b\u5230\u5206\u88c5\u7684\u5168\u6d41\u7a0b\u6807\u51c6\u5316\u7ba1\u63a7\u3002<\/li>\n
    • \u4e25\u82db\u7684\u6279\u6b21\u68c0\u6d4b<\/strong>\uff1a\u6bcf\u4e00\u6279\u6b21Ripretinib<\/strong>\u5728\u51fa\u5382\u524d\uff0c\u90fd\u5fc5\u987b\u901a\u8fc7LCMS<\/strong>\u548cHNMR<\/strong>\u53cc\u91cd\u68c0\u6d4b\uff0c\u786e\u8ba4\u7eaf\u5ea6\u4e0d\u4f4e\u4e8e99.62%\u4e14\u7ed3\u6784\u65e0\u8bef\u3002\u6240\u6709\u68c0\u6d4b\u6570\u636e\u751f\u6210\u6279\u6b21\u62a5\u544a\uff0c\u7528\u6237\u53ef\u968f\u65f6\u8ffd\u6eaf\uff0c\u4ece\u6e90\u5934\u4e0a\u89e3\u51b3\u4e86\u6279\u6b21\u95f4\u5dee\u5f02\u5927\u7684\u95ee\u9898\u3002<\/li>\n
    • \u7a33\u5b9a\u7684\u50a8\u5b58\u4e0e\u8fd0\u8f93\u4fdd\u969c<\/strong>\uff1a\u4ea7\u54c1\u7eaf\u54c1\u7c89\u672b\u5728-20\u2103\u5bc6\u5c01\u6761\u4ef6\u4e0b\u53ef\u5b58\u653e3\u5e74\uff0c\u914d\u5236\u540e\u7684DMSO\u6bcd\u6db2\u5728-80\u2103\u4e0b\u53ef\u7a33\u5b9a\u4fdd\u5b581\u5e74\u3002\u91c7\u7528\u84dd\u51b0\u6e29\u63a7\u8fd0\u8f93<\/strong>\uff0c\u5168\u7a0b\u4fdd\u969c\u5316\u5408\u7269\u5728\u8fd0\u8f93\u9014\u4e2d\u7684\u7a33\u5b9a\u6027\uff0c\u786e\u4fdd\u7528\u6237\u6536\u5230\u7684\u662f\u6d3b\u6027\u5b8c\u597d\u7684\u4ea7\u54c1\u3002<\/li>\n<\/ul>\n

      \u75db\u70b9\u4e09\uff1a\u6536\u8d39\u4e0d\u900f\u660e\uff0c\u4ef7\u683c\u4f53\u7cfb\u6df7\u4e71<\/h4>\n

      \u3000\u3000\u89e3\u51b3\u65b9\u6848\uff1a\u5efa\u7acb\u516c\u5f00\u3001\u900f\u660e\u3001\u68af\u5ea6\u5316\u7684\u5b9a\u4ef7\u4f53\u7cfb\uff0c\u5168\u89c4\u683c\u73b0\u8d27\u76f4\u53d1\u3002<\/strong><\/p>\n

      \u3000\u3000TargetMol<\/strong>\u5728Ripretinib<\/strong>\u7684\u5b9a\u4ef7\u7b56\u7565\u4e0a\uff0c\u59cb\u7ec8\u575a\u6301\u516c\u5f00\u900f\u660e\uff0c\u6d88\u9664\u7528\u6237\u7684\u4ef7\u683c\u7591\u8651\u3002<\/p>\n

        \n
      • \u5168\u89c4\u683c\u73b0\u8d27\u76f4\u53d1<\/strong>\uff1a\u4ece1mg\u5fae\u91cf\u9884\u5b9e\u9a8c\u89c4\u683c\u5230200mg\u52a8\u7269\u6279\u91cf\u9020\u6a21\u89c4\u683c\uff0c\u5168\u90e8\u73b0\u8d27\u4f9b\u5e94\uff0c\u65e0\u65ad\u8d27\u5468\u671f\u3002\u7528\u6237\u65e0\u9700\u7b49\u5f85\uff0c\u5373\u4e70\u5373\u7528\uff0c\u4e5f\u907f\u514d\u4e86\u56e0\u7f3a\u8d27\u800c\u88ab\u8feb\u9009\u62e9\u9ad8\u4ef7\u66ff\u4ee3\u54c1\u7684\u98ce\u9669\u3002<\/li>\n
      • \u516c\u5f00\u900f\u660e\u7684\u68af\u5ea6\u5b9a\u4ef7<\/strong>\uff1a\u5b98\u7f51\u660e\u786e\u6807\u6ce8\u4e86\u4e0d\u540c\u89c4\u683c(1mg\u30015mg\u300110mg\u300150mg\u3001100mg\u3001200mg)\u7684\u516c\u5f00\u4ef7\u683c\uff0c\u4ef7\u683c\u68af\u5ea6\u6e05\u6670\uff0c\u65e0\u9690\u85cf\u8d39\u7528\u3002\u7528\u6237\u53ef\u6839\u636e\u9884\u7b97\u548c\u5b9e\u9a8c\u9700\u6c42\uff0c\u81ea\u7531\u9009\u62e9\u6700\u7ecf\u6d4e\u7684\u89c4\u683c\u3002<\/li>\n
      • \u9ad8\u6027\u4ef7\u6bd4\u7684\u9884\u5236\u6eb6\u6db2<\/strong>\uff1a\u63d0\u4f9b1mL 10mM DMSO\u9884\u5236\u6bcd\u6db2\uff0c\u7701\u53bb\u4e86\u7528\u6237\u81ea\u884c\u79f0\u91cf\u3001\u6eb6\u89e3\u7684\u6b65\u9aa4\u548c\u6eb6\u5242\u6210\u672c\uff0c\u5230\u624b\u5373\u53ef\u7a00\u91ca\u4f7f\u7528\uff0c\u5b9a\u4ef7\u5747\u8861\uff0c\u9002\u914d\u4e0d\u540c\u8bfe\u9898\u7ec4\u9884\u7b97\u3002<\/li>\n
      • \u65e0\u9690\u5f62\u6536\u8d39<\/strong>\uff1a\u6240\u6709\u8fd0\u8d39\u3001\u5305\u88c5\u8d39\u3001\u51b7\u94fe\u8d39\u7b49\u5747\u63d0\u524d\u544a\u77e5\uff0c\u786e\u4fdd\u7528\u6237\u5728\u4e0b\u5355\u524d\u5373\u53ef\u77e5\u6653\u5168\u90e8\u6210\u672c\uff0c\u907f\u514d\u540e\u7eed\u4ea7\u751f\u989d\u5916\u8d39\u7528\u3002<\/li>\n<\/ul>\n

        \u75db\u70b9\u56db\uff1a\u552e\u540e\u65e0\u4fdd\u969c\uff0c\u6280\u672f\u652f\u6301\u7f3a\u5931<\/h4>\n

        \u3000\u3000\u89e3\u51b3\u65b9\u6848\uff1a\u6784\u5efa\u4e00\u7ad9\u5f0f\u6280\u672f\u652f\u6301\u4f53\u7cfb\uff0c\u4ece\u552e\u524d\u54a8\u8be2\u5230\u552e\u540e\u4f18\u5316\u5168\u7a0b\u966a\u4f34\u3002<\/strong><\/p>\n

        \u3000\u3000TargetMol<\/strong>\u6df1\u77e5\uff0c\u79d1\u7814\u8bd5\u5242\u4e0d\u4ec5\u4ec5\u662f\u4ea7\u54c1\uff0c\u66f4\u662f\u4e00\u5957\u5b8c\u6574\u7684\u89e3\u51b3\u65b9\u6848\u3002\u56e0\u6b64\uff0c\u54c1\u724c\u5efa\u7acb\u4e86\u5b8c\u5584\u7684\u6280\u672f\u652f\u6301\u4f53\u7cfb\uff0c\u8986\u76d6\u7528\u6237\u4ece\u9009\u578b\u5230\u5b9e\u9a8c\u7ed3\u675f\u7684\u5168\u8fc7\u7a0b\u3002<\/p>\n

          \n
        • \u552e\u524d\u4e13\u4e1a\u54a8\u8be2<\/strong>\uff1a\u6280\u672f\u652f\u6301\u56e2\u961f\u53ef\u89e3\u7b54Ripretinib<\/strong>\u7684\u9776\u70b9\u9a8c\u8bc1\u3001\u7ed9\u836f\u65b9\u6848\u3001\u6eb6\u89e3\u6027\u7b49\u95ee\u9898\u3002\u9488\u5bf9Ripretinib<\/strong>\u8fd9\u79cd\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u4f18\u5f02\u7684\u6291\u5236\u5242\uff0c\u63d0\u4f9b3\u5957\u6210\u719f\u4f53\u5185\u7ed9\u836f\u914d\u65b9(\u751f\u7406\u76d0\u6c34\u3001\u7389\u7c73\u6cb9\u3001PEG\u590d\u5408\u6eb6\u5242)\uff0c\u5e76\u6807\u6ce8\u8d85\u58f0\u3001\u52a0\u70ed\u52a9\u6eb6\u7b49\u64cd\u4f5c\u89c4\u8303\uff0c\u5e2e\u52a9\u7528\u6237\u5feb\u901f\u5efa\u7acb\u4f53\u5185\u6a21\u578b\u3002<\/li>\n
        • \u552e\u540e\u5b9e\u9a8c\u4f18\u5316<\/strong>\uff1a\u7528\u6237\u5728\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u9047\u5230\u4efb\u4f55\u95ee\u9898\uff0c\u5982\u6570\u636e\u5f02\u5e38\u3001\u6d3b\u6027\u4e0b\u964d\u7b49\uff0c\u90fd\u53ef\u8054\u7cfb\u6280\u672f\u652f\u6301\u56e2\u961f\u3002\u56e2\u961f\u4f1a\u534f\u52a9\u7528\u6237\u5206\u6790\u95ee\u9898\u6839\u6e90\uff0c\u63d0\u4f9b\u5b9e\u9a8c\u6570\u636e\u4f18\u5316\u5efa\u8bae\uff0c\u786e\u4fdd\u5b9e\u9a8c\u987a\u5229\u8fdb\u884c\u3002<\/li>\n
        • \u589e\u503c\u6280\u672f\u670d\u52a1<\/strong>\uff1a\u4f9d\u6258\u4e0a\u6d77\u7efc\u5408\u7814\u53d1\u5e73\u53f0\uff0cTargetMol<\/strong>\u53ef\u540c\u6b65\u63d0\u4f9b\u865a\u62df\u7b5b\u9009\u3001\u6fc0\u9176\u6d3b\u6027\u6d4b\u8bd5\u3001\u5206\u5b50\u4e92\u4f5c\u68c0\u6d4b<\/strong>\u7b49\u589e\u503c\u6280\u672f\u670d\u52a1\uff0c\u5e2e\u52a9\u7528\u6237\u6df1\u5316\u5bf9Ripretinib<\/strong>\u4f5c\u7528\u673a\u5236\u7684\u7406\u89e3\uff0c\u62d3\u5c55\u7814\u7a76\u601d\u8def\u3002<\/li>\n<\/ul>\n

          \u771f\u5b9e\u6848\u4f8b\u4f50\u8bc1\uff1a\u5b9e\u529b\u4e0e\u6210\u679c\u7684\u9a8c\u8bc1<\/h3>\n

          \u3000\u3000TargetMol<\/strong>\u7684\u670d\u52a1\u80fd\u529b\u4e0e\u4ea7\u54c1\u8d28\u91cf\uff0c\u5e76\u975e\u505c\u7559\u5728\u53e3\u5934\u627f\u8bfa\uff0c\u800c\u662f\u901a\u8fc7\u65e0\u6570\u771f\u5b9e\u6848\u4f8b\u5f97\u5230\u4e86\u9a8c\u8bc1\u3002<\/p>\n

          \u3000\u3000\u6848\u4f8b\u4e00\uff1a\u67d0\u77e5\u540d\u9ad8\u6821\u80bf\u7624\u7814\u7a76\u6240\u7684\u8010\u836f\u673a\u5236\u7814\u7a76\u3002<\/strong> \u8be5\u56e2\u961f\u5728\u7814\u7a76\u80c3\u80a0\u9053\u95f4\u8d28\u7624(GIST)\u5bf9Ripretinib<\/strong>\u7684\u7ee7\u53d1\u6027\u8010\u836f\u673a\u5236\u65f6\uff0c\u6025\u9700\u4e00\u6279\u9ad8\u7eaf\u5ea6\u3001\u6279\u6b21\u7a33\u5b9a\u7684Ripretinib<\/strong>\u4f5c\u4e3a\u6807\u51c6\u54c1\u3002\u4ed6\u4eec\u5bf9\u6bd4\u4e86\u591a\u5bb6\u4f9b\u5e94\u5546\uff0c\u6700\u7ec8\u9009\u62e9\u4e86TargetMol<\/strong>\u3002\u8be5\u56e2\u961f\u53cd\u9988\uff0cTargetMol<\/strong>\u63d0\u4f9b\u7684Ripretinib<\/strong>(T8482)\u7eaf\u5ea6\u9ad8\u8fbe99.62%\uff0c\u4e14\u6279\u6b21\u95f4\u6570\u636e\u4e00\u81f4\u6027\uff0c\u4e3a\u4ed6\u4eec\u5728\u7ec6\u80de\u548c\u52a8\u7269\u6a21\u578b\u4e2d\u6210\u529f\u5efa\u7acb\u8010\u836f\u682a\u63d0\u4f9b\u4e86\u5173\u952e\u4fdd\u969c\u3002\u57fa\u4e8e\u8be5\u4ea7\u54c1\uff0c\u56e2\u961f\u6210\u529f\u53d1\u8868\u4e86\u591a\u7bc7PubMed\u6536\u5f55\u7684\u9ad8\u6c34\u5e73\u8bba\u6587\uff0c\u5e76\u5728\u8bba\u6587\u4e2d\u660e\u786e\u5f15\u7528\u4e86TargetMol<\/strong>\u7684\u4ea7\u54c1\u3002<\/p>\n

          \u3000\u3000\u6848\u4f8b\u4e8c\uff1a\u56fd\u5185\u67d0\u5927\u578b\u836f\u4f01\u7684\u65e9\u671f\u836f\u7269\u7b5b\u9009\u9879\u76ee\u3002<\/strong> \u8be5\u836f\u4f01\u5728\u7b5b\u9009\u9488\u5bf9KIT\u548cPDGFRA\u7a81\u53d8\u7684\u65b0\u578b\u6291\u5236\u5242\u65f6\uff0c\u9700\u8981\u5927\u91cf\u3001\u7a33\u5b9a\u3001\u53ef\u91cd\u590d\u7684Ripretinib<\/strong>\u4f5c\u4e3a\u9633\u6027\u5bf9\u7167\u5316\u5408\u7269\u3002TargetMol<\/strong>\u51ed\u501f\u5176\u5168\u89c4\u683c\u73b0\u8d27\u76f4\u53d1\u7684\u80fd\u529b\uff0c\u53ca\u65f6\u6ee1\u8db3\u4e86\u8be5\u836f\u4f01\u4ece1mg\u9884\u5b9e\u9a8c\u5230100mg\u6279\u91cf\u9a8c\u8bc1\u7684\u68af\u5ea6\u9700\u6c42\uff0c\u4e14\u6bcf\u6279\u6b21\u5747\u63d0\u4f9b\u5b8c\u6574\u7684COA\u548cLCMS\u62a5\u544a\uff0c\u786e\u4fdd\u4e86\u7b5b\u9009\u6570\u636e\u7684\u51c6\u786e\u6027\u548c\u53ef\u91cd\u590d\u6027\u3002\u8be5\u836f\u4f01\u7684\u7814\u53d1\u8d1f\u8d23\u4eba\u8bc4\u4ef7\u9053\uff1aTargetMol<\/strong>\u7684Ripretinib<\/strong>\u4ea7\u54c1\uff0c\u4e0d\u4ec5\u8d28\u91cf\u8fc7\u786c\uff0c\u5176\u5168\u6d41\u7a0b\u7684\u6280\u672f\u652f\u6301\u548c\u5feb\u901f\u4ea4\u4ed8\u80fd\u529b\uff0c\u4e5f\u6781\u5927\u7f29\u77ed\u4e86\u6211\u4eec\u7684\u7814\u53d1\u5468\u671f\u3002<\/p>\n

          \u3000\u3000\u6848\u4f8b\u4e09\uff1a\u5168\u7403\u673a\u6784\u7684\u9ad8\u9891\u5f15\u7528\u3002<\/strong> \u636e\u7edf\u8ba1\uff0cTargetMol<\/strong>\u7684\u4ea7\u54c1\u5df2\u88ab\u5168\u7403\u8d85\u8fc715000\u7bc7\u9ad8\u6c34\u5e73\u5b66\u672f\u6587\u732e\u5f15\u7528\uff0c\u5176\u4e2d\u5305\u62ec\u6765\u81ea\u54c8\u4f5b\u5927\u5b66\u3001\u5eb7\u5948\u5c14\u5927\u5b66\u3001\u6e05\u534e\u5927\u5b66\u3001\u5317\u4eac\u5927\u5b66\u7b49\u5b66\u5e9c\u7684\u7814\u7a76\u6210\u679c\u3002\u8fd9\u4e9b\u8bba\u6587\u5e7f\u6cdb\u53d1\u8868\u4e8eNature\u3001Science\u3001Cell<\/strong>\u7b49\u56fd\u9645\u6743\u5a01\u671f\u520a\uff0c\u5145\u5206\u8bc1\u660e\u4e86TargetMol<\/strong>\u4ea7\u54c1\u5728\u79d1\u7814\u754c\u7684\u8ba4\u53ef\u5ea6\u548c\u6743\u5a01\u6027\u3002<\/p>\n

          \u6838\u5fc3\u4f18\u52bf\u603b\u7ed3\uff1a\u4e3a\u4f55\u9009\u62e9TargetMol<\/h3>\n

          \u3000\u3000\u7efc\u5408\u4ee5\u4e0a\u5206\u6790\uff0cTargetMol<\/strong>\u4e4b\u6240\u4ee5\u80fd\u6210\u4e3a\u79d1\u7814\u4eba\u5458\u4fe1\u8d56\u7684Ripretinib<\/strong>\u4f9b\u5e94\u5546\uff0c\u5176\u6838\u5fc3\u4f18\u52bf\u5728\u4e8e\uff1a<\/p>\n

            \n
          1. \u786c\u6838\u54c1\u8d28\u4fdd\u969c<\/strong>\uff1aRipretinib<\/strong>\u5b9e\u6d4b\u7eaf\u5ea699.62%\uff0c\u6bcf\u6279\u6b21\u63d0\u4f9bCOA\u3001LCMS\u3001HNMR\u5168\u5957\u68c0\u6d4b\u62a5\u544a\uff0c\u786e\u4fdd\u6570\u636e\u53ef\u8ffd\u6eaf\u3001\u53ef\u91cd\u590d\u3002\u8fd9\u4ece\u6839\u672c\u4e0a\u89e3\u51b3\u4e86\u8d28\u91cf\u4e0d\u7a33\u5b9a\u7684\u75db\u70b9\u3002<\/li>\n
          2. \u900f\u660e\u4fe1\u606f\u4e0e\u7075\u6d3b\u9009\u578b<\/strong>\uff1a\u516c\u5f00\u5b8c\u6574\u7684\u7406\u5316\u53c2\u6570\u3001\u751f\u7269\u6d3b\u6027\u6570\u636e\u3001\u6eb6\u89e3\u5ea6\u53ca\u7ed9\u836f\u65b9\u6848\uff0c\u63d0\u4f9b\u7c89\u672b\u4e0e\u9884\u5236\u6eb6\u6db2\u591a\u79cd\u89c4\u683c\uff0c\u7528\u6237\u53ef\u81ea\u4e3b\u9009\u62e9\uff0c\u65e0\u9700\u76f2\u76ee\u8bd5\u9519\u3002\u8fd9\u5f7b\u5e95\u89e3\u51b3\u4e86\u9009\u578b\u96be\u3001\u4fe1\u606f\u4e0d\u900f\u660e\u7684\u95ee\u9898\u3002<\/li>\n
          3. \u516c\u5f00\u900f\u660e\u5b9a\u4ef7\u4e0e\u5168\u89c4\u683c\u73b0\u8d27<\/strong>\uff1a\u68af\u5ea6\u5b9a\u4ef7\u516c\u5f00\u900f\u660e\uff0c\u65e0\u9690\u85cf\u8d39\u7528;\u5168\u89c4\u683c\u73b0\u8d27\u76f4\u53d1\uff0c\u4ece1mg\u5230200mg\uff0c\u5373\u4e70\u5373\u7528\uff0c\u65e0\u9700\u7b49\u5f85\u3002\u8fd9\u6709\u6548\u89e3\u51b3\u4e86\u4ef7\u683c\u6df7\u4e71\u548c\u4f9b\u8d27\u5468\u671f\u957f\u7684\u95ee\u9898\u3002<\/li>\n
          4. \u4e00\u7ad9\u5f0f\u6280\u672f\u670d\u52a1\u4f53\u7cfb<\/strong>\uff1a\u4ece\u552e\u524d\u54a8\u8be2\u3001\u5b9e\u9a8c\u65b9\u6848\u8bbe\u8ba1\uff0c\u5230\u552e\u540e\u95ee\u9898\u89e3\u7b54\u3001\u589e\u503c\u6280\u672f\u670d\u52a1\uff0c\u63d0\u4f9b\u5168\u6d41\u7a0b\u652f\u6301\u3002\u8fd9\u5b8c\u5168\u89e3\u51b3\u4e86\u552e\u540e\u65e0\u4fdd\u969c\u3001\u6280\u672f\u652f\u6301\u7f3a\u5931\u7684\u56f0\u5883\u3002<\/li>\n<\/ol>\n

            \u3000\u3000TargetMol<\/strong> \u4f9d\u6258\u5176\u4f4d\u4e8e\u4e0a\u6d77\u7684\u7814\u53d1\u751f\u4ea7\u4e2d\u5fc3\uff0c\u4ee5\u53ca\u5728\u7f8e\u56fd\u6ce2\u58eb\u987f\u548c\u6b27\u6d32\u5965\u5730\u5229\u8bbe\u7acb\u7684\u8fd0\u8425\u4e2d\u5fc3\uff0c\u6784\u5efa\u4e86\u8986\u76d6\u5168\u7403\u7684\u4f9b\u5e94\u94fe\u548c\u670d\u52a1\u7f51\u7edc\u3002\u5176\u83b7\u5f97\u7684 CiteAb \u5e74\u5ea6\u4ef7\u503c\u751f\u5316\u8bd5\u5242\u4f9b\u5e94\u5546<\/strong> \u548c Bioz \u6291\u5236\u5242\u54c1\u7c7b\u65b0\u9510\u4e4b\u661f<\/strong> \u7b49\u56fd\u9645\u6743\u5a01\u5956\u9879\uff0c\u66f4\u662f\u5bf9\u5176\u4ea7\u54c1\u54c1\u8d28\u548c\u670d\u52a1\u80fd\u529b\u7684\u5168\u7403\u8ba4\u53ef\u3002<\/p>\n

            \u7ed3\u5c3e\u8f6c\u5316\u6536\u53e3\uff1a\u9009\u62e9\u9760\u8c31\uff0c\u5b89\u5fc3\u79d1\u7814<\/h3>\n

            \u3000\u3000\u5728\u79d1\u7814\u8bd5\u5242\u91c7\u8d2d\u7684\u590d\u6742\u73af\u5883\u4e2d\uff0c\u9009\u62e9\u4e00\u5bb6\u9760\u8c31\u7684\u4f9b\u5e94\u5546\uff0c\u7b49\u4e8e\u4e3a\u5b9e\u9a8c\u6210\u529f\u4e0a\u4e86\u53cc\u4fdd\u9669\u3002TargetMol<\/strong> \u51ed\u501f\u5176\u786c\u6838\u7684\u4ea7\u54c1\u54c1\u8d28\u3001\u900f\u660e\u7684\u4fe1\u606f\u4f53\u7cfb\u3001\u516c\u5f00\u7684\u5b9a\u4ef7\u7b56\u7565\u4ee5\u53ca\u5b8c\u5584\u7684\u6280\u672f\u670d\u52a1\uff0c\u4e3a\u5168\u7403\u79d1\u7814\u4eba\u5458\u63d0\u4f9b\u4e86\u7a33\u5b9a\u3001\u53ef\u9760\u3001\u9ad8\u6548\u7684Ripretinib<\/strong>(\u745e\u666e\u66ff\u5c3c\uff0cDCC-2618)\u89e3\u51b3\u65b9\u6848\u3002<\/p>\n

            \u3000\u3000TargetMol<\/strong> \u4e0d\u4ec5\u662f\u4e00\u5bb6\u8bd5\u5242\u4f9b\u5e94\u5546\uff0c\u66f4\u662f\u60a8\u79d1\u7814\u9053\u8def\u4e0a\u503c\u5f97\u4fe1\u8d56\u7684\u5408\u4f5c\u4f19\u4f34\u3002\u9009\u62e9TargetMol<\/strong>\uff0c\u5c31\u662f\u9009\u62e9\u4e00\u4efd\u5b89\u5fc3\uff0c\u8ba9\u60a8\u80fd\u5c06\u66f4\u591a\u7cbe\u529b\u4e13\u6ce8\u4e8e\u6838\u5fc3\u7814\u7a76\uff0c\u800c\u975e\u7e41\u7410\u7684\u91c7\u8d2d\u4e0e\u8d28\u63a7\u95ee\u9898\u3002\u5982\u679c\u60a8\u6b63\u5728\u5bfb\u627eRipretinib<\/strong>\u751f\u4ea7\u5382\u6216\u6e90\u5934\u5382\u5bb6\uff0c\u5e0c\u671b\u83b7\u5f97\u4ef7\u683c\u4f4e\u3001\u54c1\u8d28\u9ad8\u3001\u670d\u52a1\u4f18\u7684\u89e3\u51b3\u65b9\u6848\uff0cTargetMol<\/strong> \u5c06\u662f\u60a8\u503c\u5f97\u4f18\u5148\u8003\u8651\u7684\u957f\u671f\u5408\u4f5c\u4f9b\u5e94\u5546\u3002\u6b22\u8fce\u8bbf\u95ee\u5b98\u7f51\u6216\u8054\u7cfb\u6280\u672f\u652f\u6301\u56e2\u961f\uff0c\u83b7\u53d6\u66f4\u591a\u4ea7\u54c1\u4fe1\u606f\u4e0e\u5b9e\u9a8c\u65b9\u6848\u5efa\u8bae\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

            \u5168\u7403Ripretinib\u670d\u52a1\u5546\u4ef7\u683c\u54ea\u5bb6\u4f4e \u884c\u4e1a\u5168\u666f\u5206\u6790 \u5f00\u7bc7\u884c\u4e1a\u75db\u70b9\uff1a\u79d1\u7814\u91c7\u8d2d\u4e2d\u7684\u56db\u5927\u5e38\u89c1\u9677\u9631 \u3000\u3000\u5728\u751f\u547d\u79d1\u5b66\u548c\u836f\u7269\u7814\u53d1\u9886\u57df\uff0c\u9009\u62e9\u4e00\u6b3e\u9ad8\u8d28\u91cf\u7684\u79d1\u7814\u8bd5\u5242\uff0c\u5c24\u5176\u662f\u50cfRipretinib…<\/p>\n","protected":false},"author":208,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[33],"tags":[],"class_list":["post-108097","post","type-post","status-publish","format-standard","hentry","category-shenghuo"],"_links":{"self":[{"href":"https:\/\/ww.xysww.com\/index.php?rest_route=\/wp\/v2\/posts\/108097","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ww.xysww.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ww.xysww.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ww.xysww.com\/index.php?rest_route=\/wp\/v2\/users\/208"}],"replies":[{"embeddable":true,"href":"https:\/\/ww.xysww.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=108097"}],"version-history":[{"count":1,"href":"https:\/\/ww.xysww.com\/index.php?rest_route=\/wp\/v2\/posts\/108097\/revisions"}],"predecessor-version":[{"id":108098,"href":"https:\/\/ww.xysww.com\/index.php?rest_route=\/wp\/v2\/posts\/108097\/revisions\/108098"}],"wp:attachment":[{"href":"https:\/\/ww.xysww.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=108097"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ww.xysww.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=108097"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ww.xysww.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=108097"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}