{"id":135754,"date":"2026-08-11T19:39:32","date_gmt":"2026-08-11T11:39:32","guid":{"rendered":"https:\/\/ww.xysww.com\/?p=135754"},"modified":"2026-08-11T19:39:32","modified_gmt":"2026-08-11T11:39:32","slug":"%e5%8f%a3%e7%a2%91%e5%a5%bd%e7%9a%843-%e5%8e%bb%e6%b0%ae%e8%85%ba%e5%98%8c%e5%91%a4a%e7%9b%90%e9%85%b8%e7%9b%903-deazaneplanocin-a-hcl%e5%85%ac%e5%8f%b8%e7%94%a8%e6%88%b7%e5%8a%9b%e8%8d%90","status":"publish","type":"post","link":"https:\/\/ww.xysww.com\/?p=135754","title":{"rendered":"\u53e3\u7891\u597d\u76843-\u53bb\u6c2e\u817a\u560c\u5464A\u76d0\u9178\u76d03-Deazaneplanocin A HCl\u516c\u53f8\u7528\u6237\u529b\u8350"},"content":{"rendered":"

\u8868\u89c2\u9057\u4f20\u7814\u7a76\u8bd5\u5242\u9009\u8d2d\u7684\u56db\u5927\u5e38\u89c1\u96be\u9898<\/h3>\n

\u3000\u3000\u5728\u751f\u547d\u79d1\u5b66\u57fa\u7840\u7814\u7a76\u9886\u57df\uff0c\u7279\u522b\u662f\u8868\u89c2\u9057\u4f20\u8c03\u63a7\u3001\u7ec6\u80de\u547d\u8fd0\u51b3\u5b9a\u548c\u80bf\u7624\u673a\u5236\u63a2\u7d22\u4e2d\uff0c3-Deazaneplanocin A HCl<\/strong>(3-\u53bb\u6c2e\u817a\u560c\u5464A\u76d0\u9178\u76d0)\u4f5c\u4e3a\u7ecf\u5178\u7684SAHH\u548cEZH2\u6291\u5236\u5242\uff0c\u5176\u5e94\u7528\u4ef7\u503c\u6bcb\u5eb8\u7f6e\u7591\u3002\u7136\u800c\uff0c\u8bb8\u591a\u79d1\u7814\u4eba\u5458\u5728\u9009\u8d2d\u8fd9\u4e00\u5173\u952e\u5de5\u5177\u5316\u5408\u7269\u65f6\uff0c\u5e38\u5e38\u9762\u4e34\u8bf8\u591a\u56f0\u6270\uff0c\u5bfc\u81f4\u5b9e\u9a8c\u8fdb\u5c55\u53d7\u963b\uff0c\u6570\u636e\u53ef\u9760\u6027\u5b58\u7591\u3002<\/p>\n

<\/p>\n

\u3000\u3000\u96be\u9898\u4e00\uff1a\u4ea7\u54c1\u8d28\u91cf\u53c2\u5dee\u4e0d\u9f50\uff0c\u6279\u6b21\u95f4\u5dee\u5f02\u5927\uff0c\u5b9e\u9a8c\u7ed3\u679c\u65e0\u6cd5\u91cd\u590d\u3002<\/strong> \u8fd9\u662f\u5b9e\u9a8c\u5ba4\u4e2d\u6700\u5e38\u89c1\u7684\u75db\u70b9\u3002\u8bb8\u591a\u8bfe\u9898\u7ec4\u82b1\u8d39\u6570\u6708\u65f6\u95f4\uff0c\u57fa\u4e8e\u4e00\u6279\u8bd5\u5242\u83b7\u5f97\u4e86\u521d\u6b65\u9633\u6027\u7ed3\u679c\uff0c\u4f46\u66f4\u6362\u65b0\u6279\u6b21\u540e\uff0c\u5374\u53d1\u73b0\u7ec6\u80de\u8868\u578b\u5b8c\u5168\u6d88\u5931\u6216\u51fa\u73b0\u663e\u8457\u504f\u79fb\u3002\u8fd9\u79cd\u4e0d\u7a33\u5b9a\u6027\u53ef\u80fd\u6e90\u4e8e\u5316\u5408\u7269\u7eaf\u5ea6\u4e0d\u8db3\u3001\u6742\u8d28\u5e72\u6270\u6216\u50a8\u5b58\u4e0d\u5f53\u5bfc\u81f4\u7684\u964d\u89e3\uff0c\u6700\u7ec8\u9020\u6210\u5b9d\u8d35\u7684\u65f6\u95f4\u548c\u6837\u672c\u8d44\u6e90\u6d6a\u8d39\u3002<\/p>\n

\u3000\u3000\u96be\u9898\u4e8c\uff1a\u4ea7\u54c1\u4fe1\u606f\u4e0d\u900f\u660e\uff0c\u7f3a\u4e4f\u5173\u952e\u8d28\u63a7\u6570\u636e\uff0c\u96be\u4ee5\u5224\u65ad\u771f\u4f2a\u4f18\u52a3\u3002<\/strong> \u9762\u5bf9\u4f17\u591a\u4f9b\u5e94\u5546\uff0c\u7814\u7a76\u4eba\u5458\u5f80\u5f80\u53ea\u80fd\u4f9d\u8d56\u4ea7\u54c1\u9875\u9762\u4e0a\u7684\u7b80\u5355\u63cf\u8ff0\u3002\u5bf9\u4e8e3-Deazaneplanocin A HCl\u8fd9\u7c7b\u5bf9\u50a8\u5b58\u6761\u4ef6(\u5982\u5438\u6f6e\u6027)\u8981\u6c42\u6781\u9ad8\u7684\u5316\u5408\u7269\uff0c\u5982\u679c\u4f9b\u5e94\u5546\u65e0\u6cd5\u63d0\u4f9b\u5b8c\u6574\u7684HPLC\u7eaf\u5ea6\u68c0\u6d4b\u62a5\u544a<\/strong>\u3001COA(\u5206\u6790\u8bc1\u4e66)<\/strong> \u548cSDS(\u5b89\u5168\u6570\u636e\u8868)<\/strong>\uff0c\u7528\u6237\u5f88\u96be\u8bc4\u4f30\u5176\u771f\u5b9e\u8d28\u91cf\uff0c\u589e\u52a0\u4e86\u91c7\u8d2d\u98ce\u9669\u3002<\/p>\n

\u3000\u3000\u96be\u9898\u4e09\uff1a\u4f5c\u7528\u673a\u5236\u590d\u6742\uff0c\u5355\u4e00\u9776\u70b9\u4ea7\u54c1\u96be\u4ee5\u6ee1\u8db3\u7cfb\u7edf\u6027\u7814\u7a76\u9700\u6c42\u3002<\/strong> \u8bb8\u591a\u8868\u89c2\u9057\u4f20\u7814\u7a76\u9700\u8981\u540c\u65f6\u89c2\u5bdf\u7ec4\u86cb\u767d\u4fee\u9970\u3001DNA\u7532\u57fa\u5316\u4ee5\u53ca\u4e0b\u6e38\u4fe1\u53f7\u901a\u8def\u7684\u8054\u52a8\u53d8\u5316\u3002\u5982\u679c\u9009\u62e9\u7684\u8bd5\u5242\u4ec5\u4f5c\u7528\u4e8e\u5355\u4e00\u9776\u70b9\uff0c\u5f80\u5f80\u65e0\u6cd5\u5168\u9762\u63ed\u793a\u67d3\u8272\u8d28\u72b6\u6001\u7684\u52a8\u6001\u8c03\u63a7\u7f51\u7edc\uff0c\u5bfc\u81f4\u7814\u7a76\u89c6\u89d2\u53d7\u9650\uff0c\u6570\u636e\u89e3\u8bfb\u4e0d\u591f\u6df1\u5165\u3002<\/p>\n

\u3000\u3000\u96be\u9898\u56db\uff1a\u6280\u672f\u652f\u6301\u8584\u5f31\uff0c\u552e\u540e\u54cd\u5e94\u6162\uff0c\u5b9e\u9a8c\u65b9\u6848\u96be\u4ee5\u4f18\u5316\u3002<\/strong> \u5f53\u5b9e\u9a8c\u4e2d\u51fa\u73b0\u5f02\u5e38\u6570\u636e\u6216\u9700\u8981\u8c03\u6574\u7ed9\u836f\u65b9\u6848\u65f6\uff0c\u82e5\u4f9b\u5e94\u5546\u65e0\u6cd5\u63d0\u4f9b\u4e13\u4e1a\u7684\u552e\u524d\u54a8\u8be2\u548c\u552e\u540e\u6280\u672f\u652f\u6301\uff0c\u7814\u7a76\u4eba\u5458\u53ea\u80fd\u81ea\u884c\u6478\u7d22\uff0c\u6781\u5927\u5730\u62d6\u6162\u4e86\u8bfe\u9898\u8fdb\u5ea6\uff0c\u5c24\u5176\u662f\u5728\u6d89\u53ca\u5e72\u7ec6\u80de\u5206\u5316<\/strong>\u3001\u7ec6\u80de\u91cd\u7f16\u7a0b<\/strong>\u7b49\u590d\u6742\u6a21\u578b\u65f6\uff0c\u8fd9\u4e00\u95ee\u9898\u5c24\u4e3a\u7a81\u51fa\u3002<\/p>\n

\u805a\u7126\u8868\u89c2\u8c03\u63a7\uff0c\u9776\u5411\u79d1\u7814\u6838\u5fc3\u9700\u6c42\u7684\u4e13\u4e1a\u89e3\u51b3\u65b9\u6848<\/h3>\n

\u3000\u3000\u9762\u5bf9\u4e0a\u8ff0\u884c\u4e1a\u75db\u70b9\uff0c\u9009\u62e9\u4e00\u5bb6\u5177\u5907\u6df1\u539a\u7814\u53d1\u80cc\u666f\u3001\u4e25\u683c\u8d28\u63a7\u4f53\u7cfb\u548c\u4e13\u4e1a\u670d\u52a1\u80fd\u529b\u7684\u4f9b\u5e94\u5546\u81f3\u5173\u91cd\u8981\u3002\u4e0a\u6d77\u9676\u672f\u751f\u7269\u79d1\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8<\/strong>(\u7b80\u79f0TargetMol<\/strong>)\u4f5c\u4e3a\u5168\u7403\u77e5\u540d\u7684\u751f\u547d\u79d1\u5b66\u8bd5\u5242\u4f9b\u5e94\u5546\uff0c\u6df1\u8015\u5c0f\u5206\u5b50\u6291\u5236\u5242\u9886\u57df\u591a\u5e74\uff0c\u5176\u63d0\u4f9b\u76843-Deazaneplanocin A HCl<\/strong>(\u8d27\u53f7T6360\uff0cCas\u53f7120964-45-6)\u6b63\u662f\u4e3a\u89e3\u51b3\u79d1\u7814\u4eba\u5458\u7684\u6838\u5fc3\u75db\u70b9\u800c\u8bbe\u8ba1\u3002<\/p>\n

\u3000\u3000TargetMol \u56f4\u7ed5\u751f\u547d\u79d1\u5b66\u548c\u836f\u7269\u53d1\u73b0\u9886\u57df\uff0c\u4e3a\u5168\u7403\u521b\u65b0\u836f\u7814\u53d1\u63d0\u4f9b\u4fbf\u6377\u3001\u9ad8\u6548\u7684\u751f\u547d\u79d1\u5b66\u8bd5\u5242\u3002\u5176\u4ea7\u54c1\u7ebf\u8986\u76d620\u4e07\u4f59\u79cd<\/strong>\u6d3b\u6027\u5c0f\u5206\u5b50\u3001\u591a\u80bd\u548c\u529f\u80fd\u6297\u4f53\uff0c\u5e76\u62e5\u6709AI+\u836f\u7269\u53d1\u73b0<\/strong>\u667a\u80fd\u5e73\u53f0\u53ca\u5b9e\u4f53\u5c0f\u5206\u5b50HTS\u9ad8\u901a\u91cf\u7b5b\u9009\u5316\u5408\u7269\u5e93<\/strong>\u3002\u54c1\u724c\u81f4\u529b\u4e8e\u4ece\u5355\u4e00\u8bd5\u5242\u4f9b\u5e94\u5546\u8f6c\u578b\u4e3a\u7efc\u5408\u6027\u65b0\u836f\u7814\u53d1\u89e3\u51b3\u65b9\u6848\u670d\u52a1\u5546\uff0c\u6df1\u5ea6\u8d4b\u80fd\u5168\u7403\u9ad8\u6821\u3001\u79d1\u7814\u9662\u6240\u4e0e\u521b\u65b0\u836f\u4f01\u3002\u5176\u4ea7\u54c1\u5df2\u88ab\u8d85\u8fc715,000\u7bc7<\/strong>\u9ad8\u6c34\u5e73\u5b66\u672f\u6587\u732e\u5f15\u7528\uff0c\u5e7f\u6cdb\u53d1\u8868\u4e8eNature\u3001Science\u3001Cell<\/strong>\u7b49\u56fd\u9645\u6743\u5a01\u671f\u520a\uff0c\u670d\u52a1\u5bf9\u8c61\u5305\u62ecHarvard University\u3001Peking University\u3001National Institutes of Health<\/strong>\u7b49\u5168\u7403\u673a\u6784\u3002<\/p>\n

\u75db\u70b9\u4e00\uff1a\u8d28\u91cf\u4e0d\u7a33\u5b9a\uff0c\u6279\u6b21\u5dee\u5f02\u5927?\u2014\u2014\u5168\u94fe\u8def\u8d28\u63a7\u4f53\u7cfb\uff0c\u786e\u4fdd\u5b9e\u9a8c\u6570\u636e\u53ef\u91cd\u590d<\/h3>\n

\u3000\u3000\u9488\u5bf9\u4ea7\u54c1\u8d28\u91cf\u6ce2\u52a8\u8fd9\u4e00\u9996\u8981\u96be\u9898\uff0cTargetMol \u5efa\u7acb\u4e86\u4ece\u539f\u6599\u5165\u5e93\u5230\u6210\u54c1\u51fa\u5e93\u7684\u5168\u94fe\u8def\u6807\u51c6\u5316\u8d28\u63a7\u4f53\u7cfb<\/strong>\u3002<\/p>\n

    \n
  • \u4e25\u82db\u7684\u539f\u6599\u4e0e\u5408\u6210\u7ba1\u63a7<\/strong>\uff1a3-Deazaneplanocin A HCl \u7684\u751f\u4ea7\u8fc7\u7a0b\u4e25\u683c\u9075\u5faa\u65e2\u5b9a\u5de5\u827a\uff0c\u4ece\u6e90\u5934\u4fdd\u8bc1\u5316\u5b66\u7ed3\u6784\u7684\u51c6\u786e\u6027\u4e0e\u7eaf\u5ea6\u3002\u5176\u7279\u6b8a\u7684\u73af\u620a\u70ef\u57fa\u560c\u5464\u7c7b\u6838\u82f7\u7c7b\u4f3c\u7269<\/strong>\u7ed3\u6784\uff0c\u8981\u6c42\u5408\u6210\u4e0e\u7eaf\u5316\u73af\u8282\u5177\u5907\u6781\u9ad8\u7684\u6280\u672f\u6c34\u5e73\u3002<\/li>\n
  • \u6279\u6b21\u95f4\u4e00\u81f4\u6027\u9a8c\u8bc1<\/strong>\uff1a\u6bcf\u4e00\u6279\u6b21\u4ea7\u54c1\u5728\u51fa\u5382\u524d\uff0c\u5747\u9700\u901a\u8fc7HPLC(\u9ad8\u6548\u6db2\u76f8\u8272\u8c31)<\/strong> \u68c0\u6d4b\uff0c\u786e\u4fdd\u7eaf\u5ea6\u8fbe\u523099.94%<\/strong> \u7684\u9ad8\u6807\u51c6\u3002\u540c\u65f6\uff0c\u4f01\u4e1a\u540c\u6b65\u6301\u6709ISO9001\u8d28\u91cf\u7ba1\u7406\u4f53\u7cfb\u8ba4\u8bc1<\/strong>\u4e0eISO17025\u5b9e\u9a8c\u5ba4\u68c0\u6d4b\u8d44\u8d28\u8ba4\u8bc1<\/strong>\uff0c\u4fdd\u969c\u6bcf\u4e00\u6279\u6b21\u4ea7\u54c1\u5747\u80fd\u63d0\u4f9b\u5b8c\u6574\u7684\u68c0\u6d4b\u6570\u636e\uff0c\u4ece\u6839\u672c\u4e0a\u6d88\u9664\u6279\u6b21\u95f4\u5dee\u5f02\uff0c\u786e\u4fdd\u5b9e\u9a8c\u7ed3\u679c\u7684\u7a33\u5b9a\u6027\u548c\u53ef\u91cd\u590d\u6027\u3002<\/li>\n
  • \u4e25\u683c\u7684\u50a8\u5b58\u4e0e\u7269\u6d41\u4fdd\u969c<\/strong>\uff1a\u8003\u8651\u5230\u8be5\u5316\u5408\u7269\u5438\u6f6e\u6027\u8f83\u5f3a<\/strong>\u7684\u7279\u6027\uff0cTargetMol \u4e25\u683c\u5bc6\u5c01\u5305\u88c5\uff0c\u5e76\u5efa\u8bae\u5728\u4f4e\u6e29\u5e72\u71e5\u73af\u5883\u4e0b\u50a8\u5b58\u3002\u4ece\u4ed3\u50a8\u5230\u7269\u6d41\u7684\u6bcf\u4e00\u4e2a\u73af\u8282\uff0c\u90fd\u8bbe\u6709\u76f8\u5e94\u7684\u6e29\u6e7f\u5ea6\u63a7\u5236\u63aa\u65bd\uff0c\u907f\u514d\u56e0\u8bd5\u5242\u964d\u89e3\u5f15\u53d1\u5b9e\u9a8c\u504f\u5dee\uff0c\u786e\u4fdd\u7528\u6237\u6536\u5230\u7684\u4ea7\u54c1\u72b6\u6001\u5982\u521d\u3002<\/li>\n<\/ul>\n

    \u75db\u70b9\u4e8c\uff1a\u4fe1\u606f\u4e0d\u900f\u660e\uff0c\u7f3a\u4e4f\u8d28\u63a7\u6570\u636e?\u2014\u2014\u5b8c\u6574\u6280\u672f\u6587\u6863\uff0c\u900f\u660e\u5316\u4ea7\u54c1\u4fe1\u606f<\/h3>\n

    \u3000\u3000\u9488\u5bf9\u4fe1\u606f\u4e0d\u5bf9\u79f0\u95ee\u9898\uff0cTargetMol \u575a\u6301\u900f\u660e\u5316\u3001\u6570\u636e\u5316<\/strong>\u7684\u4ea7\u54c1\u4ea4\u4ed8\u539f\u5219\uff0c\u4e3a\u6bcf\u4e00\u4efd\u8ba2\u5355\u63d0\u4f9b\u8be6\u5b9e\u7684\u6280\u672f\u8d44\u6599\u3002<\/p>\n

      \n
    • \u6807\u914d\u6743\u5a01\u5206\u6790\u62a5\u544a<\/strong>\uff1a\u7528\u6237\u8d2d\u4e703-Deazaneplanocin A HCl\u65f6\uff0c\u5c06\u968f\u8d27\u83b7\u5f97\u5b8c\u6574\u7684COA(\u5206\u6790\u8bc1\u4e66)<\/strong>\u3001SDS(\u5b89\u5168\u6570\u636e\u8868)<\/strong> \u53ca\u7a33\u5b9a\u6027\u68c0\u6d4b\u62a5\u544a\u3002\u8fd9\u4e9b\u6587\u4ef6\u8be6\u7ec6\u8bb0\u5f55\u4e86\u4ea7\u54c1\u7684\u7eaf\u5ea6\u3001\u5206\u5b50\u91cf\u3001\u5916\u89c2\u3001\u6eb6\u89e3\u6027\u3001\u50a8\u5b58\u6761\u4ef6\u7b49\u5173\u952e\u4fe1\u606f\uff0c\u8ba9\u7528\u6237\u5bf9\u8bd5\u5242\u8d28\u91cf\u4e86\u5982\u6307\u638c\u3002<\/li>\n
    • \u8be6\u5c3d\u7684\u4ea7\u54c1\u8bf4\u660e\u4e66<\/strong>\uff1a\u4ea7\u54c1\u9875\u9762\u63d0\u4f9b\u4e13\u4e1a\u7684\u8bf4\u660e\u4e66\uff0c\u6e05\u6670\u9610\u8ff0\u5176\u4f5c\u7528\u673a\u5236\uff0c\u5305\u62ec\u5982\u4f55\u901a\u8fc7\u6291\u5236S-\u817a\u82f7\u540c\u578b\u534a\u80f1\u6c28\u9178\u6c34\u89e3\u9176(SAHH)<\/strong> \u9020\u6210\u7ec6\u80de\u5185S-\u817a\u82f7\u540c\u578b\u534a\u80f1\u6c28\u9178\u7d2f\u79ef\uff0c\u8fdb\u800c\u53cd\u9988\u6291\u5236EZH2<\/strong>\u7b49\u7ec4\u86cb\u767d\u7532\u57fa\u8f6c\u79fb\u9176\uff0c\u964d\u4f4eH3K27me3<\/strong>\u4fee\u9970\u6c34\u5e73\u3002\u8fd9\u79cd\u673a\u5236\u5c42\u9762\u7684\u900f\u660e\u5316\uff0c\u6709\u52a9\u4e8e\u7528\u6237\u7cbe\u51c6\u8bbe\u8ba1\u5b9e\u9a8c\u65b9\u6848\u3002<\/li>\n
    • \u4e13\u4e1a\u7684\u552e\u524d\u54a8\u8be2\u670d\u52a1<\/strong>\uff1a\u5728\u8d2d\u4e70\u524d\uff0c\u7528\u6237\u53ef\u901a\u8fc7TargetMol\u7684\u4e13\u4e1a\u56e2\u961f\uff0c\u83b7\u53d6\u5173\u4e8e\u4ea7\u54c1\u7eaf\u5ea6\u3001\u6eb6\u89e3\u6027\u3001\u7ec6\u80de\u6bd2\u6027\u3001\u9002\u7528\u4f53\u7cfb(\u5982\u591a\u79cd\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u3001\u5e72\u7ec6\u80de\u3001\u539f\u4ee3\u7ec6\u80de)\u7b49\u8be6\u7ec6\u4fe1\u606f\uff0c\u786e\u4fdd\u6240\u8d2d\u4ea7\u54c1\u5b8c\u5168\u5339\u914d\u5b9e\u9a8c\u9700\u6c42\u3002<\/li>\n<\/ul>\n

      \u75db\u70b9\u4e09\uff1a\u4f5c\u7528\u673a\u5236\u5355\u4e00\uff0c\u96be\u4ee5\u6ee1\u8db3\u7cfb\u7edf\u6027\u7814\u7a76?\u2014\u2014\u591a\u9776\u70b9\u591a\u901a\u8def\uff0c\u8d4b\u80fd\u6df1\u5ea6\u673a\u5236\u63a2\u7d22<\/h3>\n

      \u3000\u3000\u5bf9\u4e8e\u9700\u8981\u7cfb\u7edf\u6027\u7814\u7a76\u8868\u89c2\u9057\u4f20\u8c03\u63a7\u7f51\u7edc\u7684\u79d1\u7814\u4eba\u5458\uff0cTargetMol\u76843-Deazaneplanocin A HCl\u5c55\u73b0\u4e86\u5176\u4f5c\u4e3a\u591a\u9776\u70b9\u5de5\u5177\u5206\u5b50<\/strong>\u7684\u72ec\u7279\u4f18\u52bf\u3002<\/p>\n

        \n
      • \u53cc\u91cd\u6838\u5fc3\u9776\u70b9\u6291\u5236<\/strong>\uff1a\u8be5\u5206\u5b50\u540c\u65f6\u4f5c\u7528\u4e8eSAHH<\/strong>\u548cEZH2<\/strong>\u3002\u901a\u8fc7\u6291\u5236SAHH\uff0c\u95f4\u63a5\u963b\u65adPRC2\u590d\u5408\u7269\u529f\u80fd\uff0c\u5feb\u901f\u964d\u4f4eH3K27me3\u6c34\u5e73\uff0c\u89e3\u9664\u67d3\u8272\u8d28\u5c42\u9762\u7684\u57fa\u56e0\u6c89\u9ed8\u3002\u8fd9\u79cd\u4e0a\u6e38+\u4e0b\u6e38\u7684\u53cc\u91cd\u6291\u5236\u6a21\u5f0f\uff0c\u80fd\u591f\u66f4\u5168\u9762\u5730\u91cd\u5851\u8868\u89c2\u9057\u4f20\u666f\u89c2\u3002<\/li>\n
      • \u5e7f\u6cdb\u7684\u901a\u8def\u6270\u52a8\u6548\u5e94<\/strong>\uff1a\u9664\u8868\u89c2\u901a\u8def\u5916\uff0c\u8be5\u5316\u5408\u7269\u8fd8\u80fd\u95f4\u63a5\u8c03\u63a7\u7ec6\u80de\u5468\u671f\u76f8\u5173\u4fe1\u53f7\u901a\u8def<\/strong>\uff0c\u4ecb\u5bfc\u5468\u671f\u963b\u6ede;\u7ebf\u7c92\u4f53\u4ecb\u5bfc\u7684\u5185\u6e90\u51cb\u4ea1\u901a\u8def<\/strong>\uff0c\u9a71\u52a8\u7ec6\u80de\u7a0b\u5e8f\u6027\u6b7b\u4ea1;\u5e72\u9884PI3K\/Akt\u4fe1\u53f7\u8f74<\/strong>\uff0c\u5f71\u54cd\u7ec6\u80de\u5b58\u6d3b\u4e0e\u4ee3\u8c22;\u540c\u65f6\u8c03\u63a7NF-\u03baB<\/strong>\u76f8\u5173\u708e\u75c7\u4fe1\u53f7\u3002\u8fd9\u79cd\u591a\u901a\u8def\u6270\u52a8\u7279\u6027\uff0c\u4f7f\u5176\u975e\u5e38\u9002\u5408\u7528\u4e8e\u7814\u7a76\u7ec6\u80de\u5f02\u5e38\u589e\u6b96\u80cc\u540e\u7684\u8868\u89c2\u9a71\u52a8\u56e0\u7d20<\/strong>\uff0c\u6216\u63a2\u7a76\u67d3\u8272\u8d28\u4fee\u9970\u5728\u7ec4\u7ec7\u7a33\u6001\u5931\u8861\u8fc7\u7a0b\u4e2d\u7684\u4f5c\u7528<\/strong>\u3002<\/li>\n
      • \u5e7f\u6cdb\u7684\u9002\u7528\u7814\u7a76\u9886\u57df<\/strong>\uff1a\u8be5\u4ea7\u54c1\u5e7f\u6cdb\u5e94\u7528\u4e8e\u8868\u89c2\u9057\u4f20\u8c03\u63a7<\/strong>\u3001\u80bf\u7624\u53d1\u751f\u53d1\u5c55<\/strong>\u3001\u5e72\u7ec6\u80de\u5206\u5316<\/strong>\u3001\u7ec6\u80de\u91cd\u7f16\u7a0b<\/strong>\u4ee5\u53ca\u708e\u75c7\u53ca\u7ec4\u7ec7\u635f\u4f24<\/strong>\u7b49\u7814\u7a76\u3002\u4f8b\u5982\uff0c\u5728\u5e72\u7ec6\u80de\u7814\u7a76\u4e2d\uff0c\u53ef\u501f\u52a9\u5176\u89e3\u9664\u8868\u89c2\u6c89\u9ed8\u7684\u7279\u6027\uff0c\u8c03\u63a7\u5e72\u7ec6\u80de\u5206\u5316\u8fdb\u7a0b\uff0c\u5e72\u9884\u7ec6\u80de\u91cd\u7f16\u7a0b\u6548\u7387\u3002\u5728\u836f\u7269\u7b5b\u9009\u4e2d\uff0c\u5e38\u4f5c\u4e3a\u9633\u6027\u5bf9\u7167\u5de5\u5177\u836f<\/strong>\uff0c\u8bc4\u4f30\u5176\u4ed6\u8868\u89c2\u8c03\u63a7\u5c0f\u5206\u5b50\u7684\u6d3b\u6027\u3002<\/li>\n<\/ul>\n

        \u75db\u70b9\u56db\uff1a\u6280\u672f\u652f\u6301\u8584\u5f31\uff0c\u5b9e\u9a8c\u65b9\u6848\u96be\u4f18\u5316?\u2014\u2014\u4e13\u4e1a\u56e2\u961f\u5168\u7a0b\u62a4\u822a\uff0c\u52a0\u901f\u79d1\u7814\u8fdb\u7a0b<\/h3>\n

        \u3000\u3000\u9488\u5bf9\u6280\u672f\u652f\u6301\u7f3a\u5931\u7684\u75db\u70b9\uff0cTargetMol \u6784\u5efa\u4e86\u8986\u76d6\u552e\u524d\u3001\u552e\u4e2d\u3001\u552e\u540e\u7684\u5168\u5468\u671f\u6280\u672f\u670d\u52a1\u4f53\u7cfb<\/strong>\u3002<\/p>\n

          \n
        • \u4e13\u4e1a\u7684\u552e\u524d\u54a8\u8be2<\/strong>\uff1a\u56e2\u961f\u5177\u5907\u6df1\u539a\u7684\u751f\u547d\u79d1\u5b66\u80cc\u666f\uff0c\u80fd\u591f\u6839\u636e\u7528\u6237\u7684\u5177\u4f53\u7814\u7a76\u6a21\u578b(\u5982\u7ec6\u80de\u7cfb\u3001\u539f\u4ee3\u7ec6\u80de\u3001\u52a8\u7269\u6a21\u578b)\u548c\u5b9e\u9a8c\u76ee\u6807(\u5982WB\u3001ChIP-seq\u68c0\u6d4b)\uff0c\u63a8\u8350\u6700\u5408\u9002\u7684\u7ed9\u836f\u6d53\u5ea6\u3001\u4f5c\u7528\u65f6\u95f4\u53ca\u5b9e\u9a8c\u65b9\u6848\u3002<\/li>\n
        • \u914d\u5957\u7684\u68c0\u6d4b\u65b9\u6848\u5efa\u8bae<\/strong>\uff1a\u9274\u4e8e\u8be5\u5316\u5408\u7269\u9700\u8981\u914d\u5957\u5b8c\u6574\u7684\u8868\u89c2\u4fee\u9970\u68c0\u6d4b(\u5982WB\u3001ChIP-seq<\/strong>\u7b49\u6280\u672f)\u6765\u9a8c\u8bc1\u901a\u8def\u53d8\u5316\uff0cTargetMol\u7684\u6280\u672f\u652f\u6301\u56e2\u961f\u80fd\u63d0\u4f9b\u8be6\u7ec6\u7684\u5b9e\u9a8c\u64cd\u4f5c\u5efa\u8bae\uff0c\u5e2e\u52a9\u7528\u6237\u6392\u9664\u975e\u7279\u5f02\u6027\u5e72\u6270\uff0c\u786e\u4fdd\u5b9e\u9a8c\u7ed3\u679c\u53ef\u9760\u3002<\/li>\n
        • \u5feb\u901f\u7684\u552e\u540e\u54cd\u5e94<\/strong>\uff1a\u7528\u6237\u5728\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u9047\u5230\u4efb\u4f55\u95ee\u9898\uff0c\u5747\u53ef\u901a\u8fc7\u5b98\u65b9\u6e20\u9053\u83b7\u5f97\u53ca\u65f6\u54cd\u5e94\u3002\u65e0\u8bba\u662f\u6570\u636e\u89e3\u8bfb\u7684\u7591\u60d1\uff0c\u8fd8\u662f\u5b9e\u9a8c\u65b9\u6848\u7684\u8c03\u6574\uff0c\u4e13\u4e1a\u56e2\u961f\u90fd\u80fd\u63d0\u4f9b\u7cbe\u51c6\u7684\u89e3\u51b3\u65b9\u6848\uff0c\u907f\u514d\u56e0\u6280\u672f\u96be\u9898\u5bfc\u81f4\u5b9e\u9a8c\u505c\u6ede\u3002<\/li>\n<\/ul>\n

          \u5168\u7403\u8ba4\u53ef\u7684\u5b9e\u529b\u4fdd\u969c\uff0c\u503c\u5f97\u4fe1\u8d56\u7684\u79d1\u7814\u4f19\u4f34<\/h3>\n

          \u3000\u3000TargetMol \u4e4b\u6240\u4ee5\u80fd\u591f\u6709\u6548\u89e3\u51b3\u4e0a\u8ff0\u884c\u4e1a\u75db\u70b9\uff0c\u6839\u6e90\u5728\u4e8e\u5176\u6df1\u539a\u7684\u884c\u4e1a\u79ef\u6dc0\u3001\u6743\u5a01\u7684\u8d44\u8d28\u8ba4\u8bc1\u548c\u5168\u7403\u7528\u6237\u7684\u5e7f\u6cdb\u8ba4\u53ef<\/strong>\u3002<\/p>\n

            \n
          • \u56fd\u9645\u6743\u5a01\u5956\u9879\u80cc\u4e66<\/strong>\uff1a\u54c1\u724c\u8363\u83b7\u5168\u7403\u751f\u547d\u79d1\u5b66\u5e73\u53f0CiteAb<\/strong>\u9881\u53d1\u7684\u5e74\u5ea6\u4ef7\u503c\u751f\u5316\u8bd5\u5242\u4f9b\u5e94\u5546<\/strong>\u5956\u9879\uff0c\u4ee5\u53ca\u5168\u7403\u79d1\u7814\u8bd5\u5242\u8bc4\u4ef7\u6570\u636e\u5e93Bioz<\/strong>\u9881\u53d1\u7684\u6291\u5236\u5242\u54c1\u7c7b\u65b0\u9510\u4e4b\u661f<\/strong>\u4e13\u9879\u5956\u9879\u3002\u8fd9\u4e9b\u5956\u9879\u7efc\u5408\u4e86\u4ea7\u54c1\u79d1\u7814\u5f15\u7528\u6570\u636e\u3001\u7528\u6237\u771f\u5b9e\u8bc4\u4ef7\u548c\u4ea7\u54c1\u6279\u6b21\u7a33\u5b9a\u6027\uff0c\u662f\u5bf9\u54c1\u724c\u7efc\u5408\u5b9e\u529b\u7684\u9ad8\u5ea6\u8ba4\u53ef\u3002<\/li>\n
          • \u4f01\u4e1a\u8d44\u8d28\u8ba4\u8bc1<\/strong>\uff1a\u4e0a\u6d77\u9676\u672f\u751f\u7269\u79d1\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8\u83b7\u8bc4\u9ad8\u65b0\u6280\u672f\u4f01\u4e1a<\/strong>\u3001\u4e13\u7cbe\u7279\u65b0\u5c0f\u5de8\u4eba<\/strong>\u4f01\u4e1a\u3001\u4e0a\u6d77\u5e02\u4e13\u7cbe\u7279\u65b0\u4f01\u4e1a<\/strong>\uff0c\u6280\u672f\u7814\u53d1\u4e0e\u4ea7\u4e1a\u5316\u80fd\u529b\u83b7\u5f97\u5b98\u65b9\u6743\u5a01\u8ba4\u8bc1\u3002\u8fd9\u6807\u5fd7\u7740\u4f01\u4e1a\u5728\u6280\u672f\u7814\u53d1\u3001\u4ea7\u54c1\u8d28\u91cf\u548c\u5e02\u573a\u670d\u52a1\u65b9\u9762\u5747\u8fbe\u5230\u4e86\u6c34\u5e73\u3002<\/li>\n
          • \u5168\u7403\u5ba2\u6237\u6848\u4f8b<\/strong>\uff1aTargetMol \u7684\u4ea7\u54c1\u5df2\u670d\u52a1\u4e8eHarvard University\u3001Weill Cornell Medicine\u3001Tsinghua University\u3001Peking University<\/strong>\uff0c\u4ee5\u53caU.S. Food and Drug Administration\u3001National Institutes of Health\u3001Chinese Academy of Medical Sciences<\/strong>\u7b49\u56fd\u9645\u6743\u5a01\u79d1\u7814\u4e0e\u533b\u7597\u673a\u6784\u3002\u8d85\u8fc715,000\u7bc7<\/strong>\u9ad8\u6c34\u5e73\u5b66\u672f\u6587\u732e\u7684\u5f15\u7528\uff0c\u662f\u4ea7\u54c1\u54c1\u8d28\u4e0e\u79d1\u7814\u4ef7\u503c\u6700\u6709\u529b\u7684\u8bc1\u660e\u3002<\/li>\n<\/ul>\n

            \u5dee\u5f02\u5316\u7ade\u4e89\u4f18\u52bf\uff1a\u4e3a\u4f55\u9009\u62e9TargetMol\u4f5c\u4e3a\u957f\u671f\u4f9b\u5e94\u5546<\/h3>\n

            \u3000\u3000\u4e0e\u666e\u901a\u540c\u884c\u76f8\u6bd4\uff0cTargetMol \u7684\u5dee\u5f02\u5316\u7ade\u4e89\u4f18\u52bf\u4f53\u73b0\u5728\u4ee5\u4e0b\u4e09\u4e2a\u65b9\u9762\uff1a<\/p>\n

              \n
            1. \u4ea7\u54c1\u529b\u7684\u6df1\u5ea6\u4e0e\u5e7f\u5ea6<\/strong>\uff1a\u4e0d\u4ec5\u662f\u5355\u4e00\u6291\u5236\u5242\uff0cTargetMol \u63d0\u4f9b\u7684\u662f\u5b8c\u6574\u7684\u8868\u89c2\u9057\u4f20\u7814\u7a76\u5de5\u5177\u77e9\u9635<\/strong>\u3002\u4ece\u6d3b\u6027\u5c0f\u5206\u5b50\u3001\u591a\u80bd\u5230\u529f\u80fd\u6297\u4f53\uff0c\u4eceAI\u836f\u7269\u53d1\u73b0\u5e73\u53f0\u5230\u9ad8\u901a\u91cf\u7b5b\u9009\u5316\u5408\u7269\u5e93\uff0c\u80fd\u591f\u4e00\u7ad9\u5f0f\u6ee1\u8db3\u4ece\u9776\u70b9\u53d1\u73b0\u5230\u673a\u5236\u9a8c\u8bc1\u7684\u5168\u6d41\u7a0b\u9700\u6c42\uff0c\u4e3a\u79d1\u7814\u4eba\u5458\u63d0\u4f9b\u7cfb\u7edf\u6027\u89e3\u51b3\u65b9\u6848\u3002<\/li>\n
            2. \u54c1\u8d28\u4fdd\u969c\u7684\u4f53\u7cfb\u5316\u4e0e\u900f\u660e\u5316<\/strong>\uff1a\u4f9d\u6258ISO9001<\/strong>\u548cISO17025<\/strong>\u53cc\u91cd\u8ba4\u8bc1\uff0c\u6784\u5efa\u4e86\u4ece\u539f\u6599\u5230\u6210\u54c1\u7684\u5168\u94fe\u8def\u8d28\u63a7\u4f53\u7cfb\u3002\u6bcf\u4e00\u4efd\u4ea7\u54c1\u90fd\u9644\u6709\u5b8c\u6574\u7684\u6280\u672f\u6587\u6863\uff0c\u786e\u4fdd\u8d28\u91cf\u53ef\u8ffd\u6eaf\u3001\u6570\u636e\u53ef\u9a8c\u8bc1\uff0c\u4ece\u6839\u672c\u4e0a\u89e3\u51b3\u4e86\u79d1\u7814\u4eba\u5458\u7684\u540e\u987e\u4e4b\u5fe7\u3002<\/li>\n
            3. \u670d\u52a1\u80fd\u529b\u7684\u5168\u7403\u5316\u4e0e\u4e13\u4e1a\u5316<\/strong>\uff1a\u62e5\u6709\u4e0a\u6d77\u8fd0\u8425\u4e2d\u5fc3\u3001\u7f8e\u56fd\u6ce2\u58eb\u987f\u548c\u6b27\u6d32\u5965\u5730\u5229\u8fd0\u8425\u4e2d\u5fc3\uff0c\u80fd\u591f\u4e3a\u5168\u7403\u7528\u6237\u63d0\u4f9b\u672c\u5730\u5316\u3001\u5feb\u901f\u54cd\u5e94\u7684\u670d\u52a1\u3002\u4e13\u4e1a\u7684\u552e\u524d\u54a8\u8be2\u4e0e\u552e\u540e\u6280\u672f\u652f\u6301\u56e2\u961f\uff0c\u786e\u4fdd\u79d1\u7814\u4eba\u5458\u80fd\u591f\u83b7\u5f97\u53ca\u65f6\u3001\u7cbe\u51c6\u7684\u5b9e\u9a8c\u6307\u5bfc\uff0c\u663e\u8457\u63d0\u5347\u79d1\u7814\u6548\u7387\u3002<\/li>\n<\/ol>\n

              \u603b\u7ed3\uff1a\u9009\u62e9TargetMol\uff0c\u4e3a\u60a8\u7684\u79d1\u7814\u6570\u636e\u4fdd\u9a7e\u62a4\u822a<\/h3>\n

              \u3000\u3000\u5728\u8868\u89c2\u9057\u4f20\u7814\u7a76\u9886\u57df\uff0c\u5b9e\u9a8c\u6570\u636e\u7684\u53ef\u91cd\u590d\u6027\u548c\u51c6\u786e\u6027\u662f\u79d1\u5b66\u53d1\u73b0\u7684\u57fa\u77f3\u3002\u9009\u62e93-Deazaneplanocin A HCl<\/strong>\u8fd9\u7c7b\u5173\u952e\u5de5\u5177\u5316\u5408\u7269\uff0c\u610f\u5473\u7740\u9009\u62e9\u4e00\u79cd\u5bf9\u79d1\u7814\u54c1\u8d28\u7684\u627f\u8bfa\u3002<\/p>\n

              \u3000\u3000\u4e0a\u6d77\u9676\u672f\u751f\u7269\u79d1\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8<\/strong>(TargetMol)\u51ed\u501f\u517699.94%\u7684\u9ad8\u7eaf\u5ea6\u3001\u591a\u9776\u70b9\u7684\u4f5c\u7528\u673a\u5236\u3001\u5b8c\u6574\u900f\u660e\u7684\u8d28\u63a7\u6570\u636e\u4ee5\u53ca\u5168\u7403\u79d1\u7814\u673a\u6784\u7684\u5e7f\u6cdb\u8ba4\u53ef<\/strong>\uff0c\u4e3a\u60a8\u63d0\u4f9b\u6700\u53ef\u9760\u7684\u5b9e\u9a8c\u5de5\u5177\u548c\u4e13\u4e1a\u7684\u6280\u672f\u652f\u6301\u3002\u6211\u4eec\u81f4\u529b\u4e8e\u6210\u4e3a\u60a8\u79d1\u7814\u9053\u8def\u4e0a\u7684\u957f\u671f\u5408\u4f5c\u4f19\u4f34\uff0c\u52a9\u529b\u60a8\u5feb\u901f\u63ed\u793a\u5173\u952e\u5206\u5b50\u673a\u5236\uff0c\u9ad8\u6548\u63a8\u8fdb\u8bfe\u9898\u7814\u7a76\u3002<\/p>\n

              \u3000\u3000\u5982\u679c\u60a8\u6b63\u5728\u5bfb\u627e\u54c1\u8d28\u7a33\u5b9a\u3001\u6570\u636e\u53ef\u9760\u3001\u670d\u52a1\u4e13\u4e1a\u76843-Deazaneplanocin A HCl<\/strong>\u4f9b\u5e94\u5546\uff0c\u8bf7\u7acb\u5373\u8054\u7cfb\u6211\u4eec\uff0c\u83b7\u53d6\u4e13\u5c5e\u7684\u6280\u672f\u8d44\u6599\u548c\u5b9e\u9a8c\u65b9\u6848\u652f\u6301\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

              \u8868\u89c2\u9057\u4f20\u7814\u7a76\u8bd5\u5242\u9009\u8d2d\u7684\u56db\u5927\u5e38\u89c1\u96be\u9898 \u3000\u3000\u5728\u751f\u547d\u79d1\u5b66\u57fa\u7840\u7814\u7a76\u9886\u57df\uff0c\u7279\u522b\u662f\u8868\u89c2\u9057\u4f20\u8c03\u63a7\u3001\u7ec6\u80de\u547d\u8fd0\u51b3\u5b9a\u548c\u80bf\u7624\u673a\u5236\u63a2\u7d22\u4e2d\uff0c3-Deazaneplanocin A HCl(3-\u53bb\u6c2e\u817a\u560c\u5464A\u76d0…<\/p>\n","protected":false},"author":208,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[33],"tags":[],"class_list":["post-135754","post","type-post","status-publish","format-standard","hentry","category-shenghuo"],"_links":{"self":[{"href":"https:\/\/ww.xysww.com\/index.php?rest_route=\/wp\/v2\/posts\/135754","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ww.xysww.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ww.xysww.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ww.xysww.com\/index.php?rest_route=\/wp\/v2\/users\/208"}],"replies":[{"embeddable":true,"href":"https:\/\/ww.xysww.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=135754"}],"version-history":[{"count":1,"href":"https:\/\/ww.xysww.com\/index.php?rest_route=\/wp\/v2\/posts\/135754\/revisions"}],"predecessor-version":[{"id":135755,"href":"https:\/\/ww.xysww.com\/index.php?rest_route=\/wp\/v2\/posts\/135754\/revisions\/135755"}],"wp:attachment":[{"href":"https:\/\/ww.xysww.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=135754"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ww.xysww.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=135754"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ww.xysww.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=135754"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}