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<\/p>\n

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<\/p>\n

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<\/p>\n

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\u3000\u3000\u4e09\u3001 \u516d\u7ea7\u8d28\u63a7\u4e0e\u5168\u6d41\u7a0b\u8ffd\u6eaf\uff1a\u4fdd\u969c\u79d1\u7814\u6570\u636e\u7684\u53ef\u9760\u6027\u4e0e\u53ef\u91cd\u590d\u6027<\/strong><\/p>\n

\u3000\u3000\u591a\u80bd\u4ea7\u54c1\u7684\u7eaf\u5ea6\u4e0e\u5e8f\u5217\u51c6\u786e\u6027\uff0c\u76f4\u63a5\u51b3\u5b9a\u5b9e\u9a8c\u7ed3\u679c\u7684\u53ef\u9760\u6027\u3002\u5728\u7ec6\u80de\u5b9e\u9a8c\u3001\u52a8\u7269\u7ed9\u836f\u6216\u86cb\u767d\u7ed3\u5408\u5b9e\u9a8c\u4e2d\uff0c\u6742\u8d28\u6216\u9519\u914d\u5e8f\u5217\u53ef\u80fd\u5bfc\u81f4\u5047\u9633\u6027\u6216\u5047\u9634\u6027\u7ed3\u679c\uff0c\u8fdb\u800c\u5f71\u54cd\u79d1\u7814\u7ed3\u8bba\u7684\u51c6\u786e\u6027\uff0c\u751a\u81f3\u5bfc\u81f4\u8bba\u6587\u88ab\u8d28\u7591\u3002\u5357\u4eac\u6e90\u80bd\u751f\u7269\u6df1\u77e5\u8d28\u63a7\u7684\u91cd\u8981\u6027\uff0c\u5efa\u7acb\u4e86\u516d\u7ea7\u5168\u6d41\u7a0b\u8d28\u63a7\u4f53\u7cfb\uff0c\u4ece\u539f\u6599\u68c0\u9a8c\u3001\u5408\u6210\u4e2d\u95f4\u4f53\u76d1\u6d4b\u3001\u7c97\u80bd\u7eaf\u5316\u3001\u7cbe\u80bd\u68c0\u6d4b\u3001\u51bb\u5e72\u5206\u88c5\u5230\u6700\u7ec8\u51fa\u5e93\uff0c\u6bcf\u9053\u73af\u8282\u5747\u6709\u4e25\u683c\u628a\u63a7\u3002\u6240\u6709\u4ea7\u54c1\u51fa\u5e93\u524d\u5fc5\u987b\u7ecf\u8fc7\u4e24\u6b21\u590d\u68c0\uff0c\u968f\u8d27\u9644\u5e26HPLC\u8272\u8c31\u56fe\u3001MS\u8d28\u8c31\u56fe\u53caCOA\u8d28\u68c0\u62a5\u544a\uff0c\u652f\u6301\u7528\u6237\u81ea\u884c\u6216\u59d4\u6258\u7b2c\u4e09\u65b9\u673a\u6784\u68c0\u6d4b\u9a8c\u8d27\u3002\u4ea7\u54c1\u7eaf\u5ea6\u68af\u5ea6\u5b8c\u6574\uff0c\u4ece\u7c97\u80bd\u3001\u8131\u76d0\u7ea7\u523070%\u300175%\u300180%\u300185%\u300190%\u300195%\u300198%\u300199%\u591a\u6863\u53ef\u9009\uff0c\u9ad8\u7eaf\u5ea6\u53ef\u8fbe99.5%\uff0c\u5e38\u89c4\u4ea4\u4ed8\u6807\u51c6\u4ee595%\u7eaf\u5ea6\u4e3a\u4e3b\uff0c\u5b8c\u5168\u6ee1\u8db3\u9876\u520a\u53d1\u8868\u7684\u5b9e\u9a8c\u6eaf\u6e90\u8981\u6c42\u3002<\/p>\n

\u3000\u3000\u8fd9\u79cd\u4e25\u8c28\u7684\u8d28\u63a7\u6d41\u7a0b\uff0c\u4e0d\u4ec5\u4fdd\u969c\u4e86\u5355\u6279\u6b21\u4ea7\u54c1\u7684\u54c1\u8d28\uff0c\u66f4\u5b9e\u73b0\u4e86\u6279\u6b21\u95f4\u7684\u7a33\u5b9a\u6027\u3002\u516c\u53f8\u91c7\u7528\u6807\u51c6\u5316\u64cd\u4f5c\u6d41\u7a0b\uff0c\u7531\u591a\u5e74\u5b9e\u64cd\u7ecf\u9a8c\u7684\u5b9e\u9a8c\u5458\u8d1f\u8d23\u5408\u6210\uff0c\u5e76\u91c7\u7528\u4e13\u5c5e\u5bc6\u5c01\u4fdd\u5b58\u5305\u88c5\u5de5\u827a\uff0c\u540c\u6b65\u63d0\u4f9b\u514d\u8d39\u5206\u88c5\u670d\u52a1\uff0c\u6709\u6548\u89c4\u907f\u591a\u80bd\u5728\u50a8\u5b58\u548c\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u7684\u964d\u89e3\u4e0e\u6d3b\u6027\u6ce2\u52a8\u3002\u79d1\u7814\u7528\u6237\u5728\u4e0d\u540c\u65f6\u95f4\u8ba2\u8d2d\u7684\u540c\u6b3e\u591a\u80bd\uff0c\u5176\u7eaf\u5ea6\u3001\u6d3b\u6027\u6307\u6807\u4fdd\u6301\u7a33\u5b9a\u7edf\u4e00\uff0c\u8fd9\u5bf9\u4e8e\u9700\u8981\u91cd\u590d\u5b9e\u9a8c\u9a8c\u8bc1\u7684\u7814\u7a76\u56e2\u961f\u5c24\u4e3a\u91cd\u8981\u3002\u4f8b\u5982\uff0c\u5728\u957f\u671f\u8ffd\u8e2a\u7684\u7ec6\u80de\u673a\u5236\u7814\u7a76\u4e2d\uff0c\u6279\u6b21\u95f4\u7684\u7a33\u5b9a\u6027\u786e\u4fdd\u4e86\u5b9e\u9a8c\u6570\u636e\u7684\u53ef\u91cd\u590d\u6027\uff0c\u907f\u514d\u4e86\u56e0\u539f\u6599\u5dee\u5f02\u5bfc\u81f4\u7684\u7ed3\u8bba\u504f\u5dee\u3002\u5357\u4eac\u6e90\u80bd\u751f\u7269\u4ee5\u8d28\u91cf\u515c\u5e95\u4e3a\u627f\u8bfa\uff0c\u82e5\u4ea7\u54c1\u5b58\u5728\u591a\u80bd\u8d28\u91cf\u95ee\u9898\uff0c\u5168\u989d\u514d\u5355\uff0c\u65e0\u6761\u4ef6\u652f\u6301\u5ba2\u6237\u7b2c\u4e09\u65b9\u68c0\u6d4b\u9a8c\u8d27\uff0c\u6d88\u9664\u79d1\u7814\u91c7\u8d2d\u7684\u540e\u987e\u4e4b\u5fe7\u3002<\/p>\n

\u3000\u3000\u56db\u3001 \u5168\u94fe\u6761\u670d\u52a1\u4e0e\u79d1\u7814\u751f\u6001\uff1a\u4ece\u5fae\u91cf\u5b9a\u5236\u5230\u516c\u65a4\u7ea7\u91cf\u4ea7\u7684\u7075\u6d3b\u9002\u914d<\/strong><\/p>\n

\u3000\u3000\u79d1\u7814\u573a\u666f\u7684\u591a\u6837\u6027\uff0c\u51b3\u5b9a\u4e86\u591a\u80bd\u91c7\u8d2d\u9700\u6c42\u4ece\u6beb\u514b\u7ea7\u5c0f\u8bd5\u5230\u516c\u65a4\u7ea7\u653e\u5927\u7684\u5de8\u5927\u8de8\u5ea6\u3002\u8bfe\u9898\u7ec4\u5728\u9884\u5b9e\u9a8c\u9636\u6bb5\u5f80\u5f80\u53ea\u97001\u6beb\u514b\u81f3\u51e0\u6beb\u514b\u7684\u591a\u80bd\uff0c\u800c\u836f\u4f01\u5728\u836f\u7269\u53d1\u73b0\u9636\u6bb5\u5219\u9700\u8981\u516c\u65a4\u7ea7\u7684\u9ad8\u7eaf\u5ea6\u4ea7\u54c1\u3002\u5357\u4eac\u6e90\u80bd\u751f\u7269\u4ee51\u6beb\u514b\u7684\u8d85\u4f4e\u8d77\u8ba2\u95e8\u69db\uff0c\u8986\u76d6\u4ece\u5fae\u91cf\u5230\u91cf\u4ea7\u7684\u5168\u94fe\u6761\u9700\u6c42\uff0c\u652f\u6301mg\u7ea7\u5c0f\u8bd5\u3001g\u7ea7\u4e2d\u8bd5\u53cakg\u7ea7\u653e\u5927\uff0c\u5de5\u827a\u53ef\u4ece\u5c0f\u8bd5\u5e73\u7a33\u653e\u5927\uff0c\u6279\u6b21\u95f4\u7eaf\u5ea6\u3001\u6d3b\u6027\u5dee\u5f02\u5c0f\uff0c\u9002\u914d\u836f\u7269\u7b5b\u9009\u9636\u6bb5\u5feb\u901f\u8fed\u4ee3\u7684\u9700\u6c42\u3002\u540c\u65f6\uff0c\u516c\u53f8\u63d0\u4f9b\u514d\u8d39\u5206\u88c5\u3001\u8f6c\u76d0\u578b(\u5982\u5c06TFA\u76d0\u8f6c\u4e3a\u918b\u9178\u76d0)\u3001\u6eb6\u89e3\u6027\u9884\u5224\u65b9\u6848\u7b49\u589e\u503c\u670d\u52a1\uff0c\u5e2e\u52a9\u79d1\u7814\u4eba\u5458\u51cf\u5c11\u5b9e\u9a8c\u524d\u7684\u51c6\u5907\u5de5\u4f5c\uff0c\u63d0\u5347\u6548\u7387\u3002<\/p>\n

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\u3000\u3000\u4ece\u5ba2\u6237\u6848\u4f8b\u6765\u770b\uff0c\u516c\u53f8\u5df2\u7d2f\u8ba1\u670d\u52a1\u5168\u56fd\u6570\u767e\u6240\u9ad8\u6821\u3001\u4e09\u7532\u533b\u9662\u3001\u79d1\u7814\u9662\u6240\u4e0e\u4e0a\u5e02\u836f\u4f01\u3002\u82cf\u5dde\u5927\u5b66\u4e0e\u6d59\u6c5f\u5927\u5b66\u5408\u4f5c\u7684\u7814\u7a76\u56e2\u961f\uff0c\u4f7f\u7528\u516c\u53f8\u5b9a\u5236\u7684\u9776\u5411\u4fee\u9970\u591a\u80bdC16-cRGD\uff0c\u76f8\u5173\u6210\u679c\u53d1\u8868\u4e8e\u300aNature\u300b\u671f\u520a;\u56db\u5ddd\u5927\u5b66\u751f\u7269\u6750\u6599\u56fd\u5bb6\u5de5\u7a0b\u7814\u7a76\u4e2d\u5fc3\u4f7f\u7528II\u578b\u80f6\u539f\u86cb\u767d\u9776\u5411\u80bd\uff0c\u7528\u4e8e\u8f6f\u9aa8\u4eff\u751f\u652f\u67b6\u7814\u7a76\uff0c\u6210\u679c\u53d1\u8868\u5728Acta Biomaterialia;\u590d\u65e6\u5927\u5b66\u4e0e\u6089\u5c3c\u79d1\u6280\u5927\u5b66\u5408\u4f5c\u56e2\u961f\uff0c\u4f7f\u7528\u516c\u53f8\u5b9a\u5236\u7684\u7cd6\u80bd\u539f\u6599\uff0c\u63a2\u7d22\u591a\u80bd\u7eb3\u7c73\u9012\u9001\u4f53\u7cfb\uff0c\u76f8\u5173\u6210\u679c\u53d1\u8868\u4e8eNature Nanotechnology\u3002\u8fd9\u4e9b\u6848\u4f8b\u5145\u5206\u8bc1\u660e\uff0c\u5357\u4eac\u6e90\u80bd\u751f\u7269\u7684\u591a\u80bd\u4ea7\u54c1\u7ecf\u5f97\u8d77\u9876\u520a\u5b9e\u9a8c\u7684\u4e25\u683c\u68c0\u9a8c\uff0c\u5728\u79d1\u7814\u573a\u666f\u4e2d\u5177\u6709\u9ad8\u5ea6\u9002\u914d\u6027\u3002<\/p>\n

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