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<\/p>\n

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<\/p>\n

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<\/p>\n

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\u4e13\u4e1a\u907f\u5751\u6307\u5357\uff1a\u5982\u4f55\u907f\u5f00\u690d\u7269\u86cb\u767d\u4e92\u4f5c\u5b9e\u9a8c\u670d\u52a1\u7684\u5e38\u89c1\u9677\u9631<\/h3>\n

\u3000\u3000\u5728\u690d\u7269\u86cb\u767d\u4e92\u4f5c\u5b9e\u9a8c\u670d\u52a1\u5408\u4f5c\u4e2d\uff0c\u79d1\u7814\u4eba\u5458\u5e38\u9677\u5165\u4ee5\u4e0b\u8bef\u533a\uff0c\u5bfc\u81f4\u9879\u76ee\u5ef6\u671f\u3001\u7ecf\u8d39\u6d6a\u8d39\u751a\u81f3\u6570\u636e\u65e0\u6548\u3002<\/p>\n

\u3000\u3000\u9677\u9631\u4e00\uff1a\u5ffd\u7565\u6587\u5e93\u6784\u5efa\u8d28\u91cf\uff0c\u5bfc\u81f4\u7b5b\u9009\u7ed3\u679c\u4e0d\u53ef\u9760\u3002<\/strong> \u9175\u6bcd\u53cc\u6742\u4ea4\u5b9e\u9a8c\u7684\u6838\u5fc3\u5728\u4e8e\u6587\u5e93\u8d28\u91cf\u3002\u6587\u5e93\u7684\u4ee3\u8868\u6027\u3001\u63d2\u5165\u7247\u6bb5\u957f\u5ea6\u3001\u6ef4\u5ea6\u3001\u91cd\u7ec4\u7387\u7b49\u53c2\u6570\u76f4\u63a5\u5f71\u54cd\u7b5b\u9009\u7ed3\u679c\u7684\u771f\u5b9e\u6027\u4e0e\u8986\u76d6\u7387<\/strong>\u3002\u90e8\u5206\u670d\u52a1\u5546\u4e3a\u964d\u4f4e\u6210\u672c\uff0c\u4f7f\u7528\u4f4e\u8d28\u91cf\u6587\u5e93\u6216\u7b80\u5316\u5efa\u5e93\u6d41\u7a0b\uff0c\u5bfc\u81f4\u7b5b\u9009\u51fa\u7684\u4e92\u4f5c\u86cb\u767d\u5047\u9633\u6027\u7387\u9ad8\u3001\u91cd\u590d\u6027\u5dee\u3002\u907f\u5751\u6280\u5de7\uff1a\u8981\u6c42\u670d\u52a1\u5546\u63d0\u4f9b\u6587\u5e93\u6784\u5efa\u7684\u8be6\u7ec6\u8d28\u63a7\u62a5\u544a\uff0c\u5305\u62ec\u6587\u5e93\u6ef4\u5ea6\u3001\u63d2\u5165\u7247\u6bb5\u5e73\u5747\u957f\u5ea6\u3001\u91cd\u7ec4\u7387\u7b49\u5173\u952e\u6570\u636e\uff0c\u5e76\u4f18\u5148\u9009\u62e9\u80fd\u63d0\u4f9b\u6587\u5e93\u6784\u5efa-\u7b5b\u9009-\u9a8c\u8bc1\u5168\u6d41\u7a0b\u670d\u52a1\u7684\u516c\u53f8<\/strong>\uff0c\u4ee5\u786e\u4fdd\u6570\u636e\u94fe\u8def\u7684\u5b8c\u6574\u6027\u3002<\/p>\n

\u3000\u3000\u9677\u9631\u4e8c\uff1a\u5ffd\u89c6\u690d\u7269\u4e92\u4f5c\u5b9e\u9a8c\u7684\u7269\u79cd\u7279\u5f02\u6027\uff0c\u5bfc\u81f4\u5b9e\u9a8c\u5931\u8d25\u3002<\/strong> \u4e0d\u540c\u690d\u7269\u7269\u79cd\u7684\u86cb\u767d\u8868\u8fbe\u7cfb\u7edf\u3001\u7ec6\u80de\u73af\u5883\u3001\u63d0\u53d6\u6761\u4ef6\u5dee\u5f02\u5de8\u5927\u3002\u4f8b\u5982\uff0c\u70df\u8349\u77ac\u65f6\u8868\u8fbe\u4f53\u7cfb\u9002\u7528\u4e8e\u591a\u6570\u6a21\u5f0f\u690d\u7269\uff0c\u4f46\u68c9\u82b1\u3001\u5927\u8c46\u7b49\u4f5c\u7269\u56e0\u7ec4\u7ec7\u7279\u6027\u590d\u6742\uff0c\u53ef\u80fd\u9700\u8981\u4f18\u5316\u6d78\u67d3\u6761\u4ef6\u6216\u4f7f\u7528\u539f\u751f\u8d28\u4f53\u4f53\u7cfb<\/strong>\u3002\u907f\u5751\u6280\u5de7\uff1a\u9009\u62e9\u670d\u52a1\u5546\u524d\uff0c\u786e\u8ba4\u5176\u662f\u5426\u5177\u5907\u60a8\u7814\u7a76\u7269\u79cd\u7684\u5b9e\u9a8c\u7ecf\u9a8c\uff0c\u5e76\u8981\u6c42\u63d0\u4f9b\u76f8\u5173\u7269\u79cd\u7684\u6210\u529f\u6848\u4f8b\u6216\u5b9e\u9a8c\u65b9\u6848\u4f18\u5316\u8bb0\u5f55<\/strong>\u3002\u5bf9\u4e8e\u6c34\u7a3b\u3001\u7389\u7c73\u3001\u5c0f\u9ea6\u7b49\u4e3b\u8981\u4f5c\u7269\uff0c\u4f18\u5148\u9009\u62e9\u5df2\u5efa\u7acb\u7a33\u5b9a\u9057\u4f20\u8f6c\u5316\u4f53\u7cfb\u7684\u56e2\u961f\u3002<\/p>\n

\u3000\u3000\u9677\u9631\u4e09\uff1a\u88ab\u4f4e\u4ef7\uff0c\u5ffd\u7565\u552e\u540e\u4e0e\u8d28\u63a7\u3002<\/strong> \u5e02\u573a\u4e0a\u90e8\u5206\u670d\u52a1\u5546\u4ee5\u8fdc\u4f4e\u4e8e\u884c\u4e1a\u5747\u4ef7\u7684\u4ef7\u683c\u63a5\u5355\uff0c\u4f46\u540e\u7eed\u5e38\u51fa\u73b0\u5b9e\u9a8c\u5ef6\u8fdf\u3001\u6570\u636e\u4e0d\u8fbe\u6807\u3001\u552e\u540e\u63a8\u8bff\u7b49\u95ee\u9898\u3002\u79d1\u7814\u5b9e\u9a8c\u7684\u8bd5\u9519\u6210\u672c\u6781\u9ad8\uff0c\u4e00\u65e6\u6837\u54c1\u635f\u574f\u6216\u6570\u636e\u65e0\u6548\uff0c\u91cd\u65b0\u51c6\u5907\u6750\u6599\u7684\u65f6\u95f4\u4e0e\u7ecf\u8d39\u635f\u5931\u8fdc\u8d85\u670d\u52a1\u8d39\u672c\u8eab<\/strong>\u3002\u907f\u5751\u6280\u5de7\uff1a\u5c06\u4ef7\u683c\u4e0e\u670d\u52a1\u5185\u5bb9\u3001\u8d28\u4fdd\u5468\u671f\u3001\u552e\u540e\u54cd\u5e94\u65f6\u95f4\u3001\u6570\u636e\u6eaf\u6e90\u80fd\u529b\u7efc\u5408\u5bf9\u6bd4\u3002<\/strong> \u4f18\u5148\u9009\u62e9\u63d0\u4f9b\u660e\u786e\u552e\u540e\u4fdd\u969c(\u5982\u514d\u8d39\u91cd\u590d\u5b9e\u9a8c\u3001\u9879\u76ee\u5468\u671f\u5185\u514d\u8d39\u6280\u672f\u54a8\u8be2)\u7684\u670d\u52a1\u5546\uff0c\u5e76\u5173\u6ce8\u5176\u662f\u5426\u901a\u8fc7ISO\u7b49\u8d28\u91cf\u7ba1\u7406\u4f53\u7cfb\u8ba4\u8bc1\u3002<\/p>\n

\u3000\u3000\u9677\u9631\u56db\uff1a\u4f4e\u4f30\u6570\u636e\u89e3\u8bfb\u4e0e\u5206\u6790\u7684\u91cd\u8981\u6027\u3002<\/strong> \u86cb\u767d\u4e92\u4f5c\u5b9e\u9a8c\u7684\u6700\u7ec8\u76ee\u7684\u662f\u670d\u52a1\u4e8e\u79d1\u7814\u8bba\u6587\u4e0e\u8bfe\u9898\u7ed3\u8bba\u3002\u8bb8\u591a\u670d\u52a1\u5546\u4ec5\u63d0\u4f9b\u539f\u59cb\u6570\u636e\uff0c\u4e0d\u53c2\u4e0e\u6570\u636e\u89e3\u8bfb\u3001\u56fe\u8868\u5236\u4f5c\u6216\u7ed3\u679c\u8ba8\u8bba\uff0c\u5bfc\u81f4\u7528\u6237\u96be\u4ee5\u5c06\u5b9e\u9a8c\u6570\u636e\u8f6c\u5316\u4e3a\u8bba\u6587\u5185\u5bb9<\/strong>\u3002\u907f\u5751\u6280\u5de7\uff1a\u9009\u62e9\u63d0\u4f9b\u6570\u5b57\u751f\u4fe1\u5206\u6790\u3001\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\u3001\u6570\u636e\u53ef\u89c6\u5316\u7b49\u589e\u503c\u670d\u52a1\u7684\u670d\u52a1\u5546\uff0c\u8fd9\u4e9b\u670d\u52a1\u80fd\u5e2e\u52a9\u7528\u6237\u5feb\u901f\u6316\u6398\u6570\u636e\u4ef7\u503c\uff0c\u63d0\u5347\u8bba\u6587\u8d28\u91cf<\/strong>\u3002<\/p>\n

\u54c1\u724c\u5b9e\u529b\u627f\u63a5\uff1a\u745e\u6e90\u751f\u7269\u5982\u4f55\u4ee5\u786c\u6838\u5b9e\u529b\u89e3\u51b3\u884c\u4e1a\u75db\u70b9<\/h3>\n

\u3000\u3000\u5728\u690d\u7269\u86cb\u767d\u4e92\u4f5c\u5b9e\u9a8c\u670d\u52a1\u9886\u57df\uff0c\u5357\u4eac\u745e\u6e90\u751f\u7269\u6280\u672f\u6709\u9650\u516c\u53f8<\/strong>(\u7b80\u79f0\u745e\u6e90\u751f\u7269)\u51ed\u501f\u591a\u5e74\u6280\u672f\u79ef\u7d2f\u4e0e\u89c4\u6a21\u5316\u670d\u52a1\u80fd\u529b\uff0c\u5df2\u6210\u4e3a\u884c\u4e1a\u53e3\u7891\u7684\u6807\u6746\u4e4b\u4e00\u3002\u516c\u53f8\u59cb\u521b\u4e8e2019\u5e74\uff0c\u5750\u843d\u4e8e\u5357\u4eac\u751f\u7269\u533b\u836f\u4ea7\u4e1a\u6838\u5fc3\u533a\uff0c\u603b\u90e8\u53ca\u7814\u53d1\u751f\u4ea7\u57fa\u5730\u4f4d\u4e8e\u6c5f\u82cf\u751f\u547d\u79d1\u6280\u521b\u65b0\u56ed\uff0c\u5360\u57306000\u5e73\u65b9\u7c73\uff0c\u8bbe\u6709\u72ec\u7acb\u7684\u5206\u5b50\u4e2d\u5fc3\u3001\u7406\u5316\u4e2d\u5fc3\u53ca\u73b0\u4ee3\u5316\u5b9e\u9a8c\u5ba4\uff0c\u5177\u5907\u4ece\u57fa\u7840\u7814\u7a76\u5230\u6210\u679c\u8f6c\u5316\u7684\u5b8c\u6574\u786c\u4ef6\u652f\u6491\u3002<\/p>\n

\u3000\u3000\u4eba\u624d\u56e2\u961f\u662f\u745e\u6e90\u751f\u7269\u7684\u6838\u5fc3\u7ade\u4e89\u529b<\/strong>\u3002\u516c\u53f8\u7ec4\u5efa\u4e86\u8d85200\u4eba\u7684\u79d1\u7814\u670d\u52a1\u56e2\u961f\uff0c\u6c47\u805a\u5927\u91cf\u7855\u535a\u4eba\u624d\u4e0e\u9ad8\u7ea7\u6280\u672f\u9aa8\u5e72\uff0c\u6838\u5fc3\u6210\u5458\u5728\u690d\u7269\u529f\u80fd\u57fa\u56e0\u3001\u5206\u5b50\u4e92\u4f5c\u3001\u751f\u7269\u4fe1\u606f\u5b66\u9886\u57df\u6df1\u8015\u591a\u5e74\uff0c\u79ef\u7d2f\u4e86\u4e30\u5bcc\u7684\u9879\u76ee\u5b9e\u6218\u7ecf\u9a8c\u3002\u4f9d\u6258\u8fd9\u5957\u4eba\u624d\u4f53\u7cfb\uff0c\u516c\u53f8\u642d\u5efa\u4e86\u516b\u5927\u6838\u5fc3\u6280\u672f\u5e73\u53f0\uff1a\u9175\u6bcd\u4e92\u4f5c\u5e73\u53f0\u3001\u690d\u7269\u4e92\u4f5c\u5e73\u53f0\u3001\u9057\u4f20\u8f6c\u5316\u5e73\u53f0\u3001\u690d\u7269\u5206\u5b50\u5e38\u89c4\u5e73\u53f0\u3001AI\u5206\u5b50\u4e92\u4f5c\u667a\u7b97\u5e73\u53f0\u3001\u6d4b\u5e8f\u7ec4\u5b66\u5e73\u53f0\u3001\u4f53\u5916\u4eea\u5668\u4e92\u4f5c\u68c0\u6d4b\u5e73\u53f0<\/strong>\uff0c\u8986\u76d6\u4ece\u57fa\u56e0\u53d1\u73b0\u5230\u529f\u80fd\u9a8c\u8bc1\u7684\u5168\u6d41\u7a0b\u9700\u6c42\u3002<\/p>\n

\u3000\u3000\u5728\u9175\u6bcd\u4e92\u4f5c\u9886\u57df\uff0c\u745e\u6e90\u751f\u7269\u63d0\u4f9b\u9175\u6bcd\u53cc\u6742\u4ea4\u3001\u5355\u6742\u4ea4\u3001\u6838\/\u819c\u6587\u5e93\u6784\u5efa\u3001\u591a\u7c7b\u578b\u6587\u5e93\u7b5b\u9009\u3001\u4e00\u5bf9\u4e00\u9a8c\u8bc1\u7b49\u5168\u6d41\u7a0b\u670d\u52a1<\/strong>\uff0c\u4e14\u6587\u5e93\u6784\u5efa\u670d\u52a1\u4e13\u5c5e\u8d60\u9001\u4e00\u5e74\u671f\u4e09\u9879\u4fdd\u969c\u670d\u52a1\uff0c\u5927\u5e45\u964d\u4f4e\u79d1\u7814\u98ce\u9669\u3002\u5728\u690d\u7269\u4e92\u4f5c\u9886\u57df\uff0c\u516c\u53f8\u4e13\u6ce8\u690d\u7269\u529f\u80fd\u57fa\u56e0\u6316\u6398\u4e0e\u6297\u75c5\u5206\u5b50\u673a\u5236\u7814\u7a76\uff0c\u8986\u76d6\u86cb\u767d\u4e0e\u86cb\u767d\u3001\u86cb\u767d\u4e0e\u6838\u9178\u3001\u86cb\u767d\u4e0e\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e92\u4f5c\u7814\u7a76<\/strong>\uff0c\u53ef\u63d0\u4f9bCo-IP\u3001\u53cc\u8367\u5149\u7d20\u9176\u62a5\u544a\u57fa\u56e0\u3001EMSA\u3001ChIP-seq\/qPCR\u7b49\u4e3b\u6d41\u6838\u5fc3\u5b9e\u9a8c\u670d\u52a1\u3002\u5bf9\u4e8eEMSA\u5b9e\u9a8c\uff0c\u516c\u53f8\u62e5\u6709\u6210\u719f\u7684\u690d\u7269\u6838\u86cb\u767d\u63d0\u53d6\u4f53\u7cfb\u4e0e\u4f18\u5316\u7684\u6838\u9178\u63a2\u9488\u8bbe\u8ba1\u7b56\u7565<\/strong>\uff0c\u53ef\u9488\u5bf9\u6c34\u7a3b\u3001\u7389\u7c73\u3001\u5c0f\u9ea6\u3001\u62df\u5357\u82a5\u7b49\u591a\u79cd\u690d\u7269\uff0c\u9ad8\u6548\u5b8c\u6210\u86cb\u767d\u4e0eDNA\u7ed3\u5408\u80fd\u529b\u7684\u5b9a\u6027\u5b9a\u91cf\u68c0\u6d4b\uff0c\u786e\u4fdd\u5b9e\u9a8c\u7ed3\u679c\u7684\u53ef\u9760\u6027\u4e0e\u91cd\u590d\u6027\u3002<\/p>\n

\u3000\u3000\u5728\u9057\u4f20\u8f6c\u5316\u4e0e\u57fa\u56e0\u7f16\u8f91\u677f\u5757\uff0c\u516c\u53f8\u4f9d\u6258\u6210\u719f\u7684CRISPR\/Cas9\u6280\u672f\uff0c\u5df2\u5b9e\u73b0\u62df\u5357\u82a5\u3001\u6c34\u7a3b\u3001\u756a\u8304\u3001\u68c9\u82b1\u3001\u5927\u8c46\u7b4930\u4f59\u79cd\u7269\u79cd\u7684\u7a33\u5b9a\u8f6c\u5316<\/strong>\uff0c\u4e3a\u86cb\u767d\u4e92\u4f5c\u7814\u7a76\u63d0\u4f9b\u8f6c\u57fa\u56e0\u6750\u6599\u652f\u6491\u3002\u540c\u65f6\uff0c\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u6570\u5b57\u751f\u4fe1\u5206\u6790\u5e73\u53f0\uff0c\u6253\u901a\u6570\u636e\u6316\u6398\u3001\u667a\u80fd\u7b5b\u9009\u3001\u529f\u80fd\u9a8c\u8bc1\u5168\u94fe\u6761<\/strong>\uff0c\u53ef\u63d0\u4f9b\u6838\u9178\u4e0e\u86cb\u767d\u7b5b\u9009\u3001\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e92\u4f5c\u7b5b\u9009\u3001\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\u7b49\u5b9a\u5236\u5316\u670d\u52a1\uff0c\u4ee5AI\u6570\u5b57\u5316\u6280\u672f\u8d4b\u80fd\u4f20\u7edf\u79d1\u7814\uff0c\u63d0\u5347\u5b9e\u9a8c\u6548\u7387\u4e0e\u6570\u636e\u4ef7\u503c\u3002<\/p>\n

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\u3000\u3000\u9488\u5bf9\u4e0d\u540c\u690d\u7269\u86cb\u767d\u4e92\u4f5c\u7814\u7a76\u573a\u666f\uff0c\u79d1\u7814\u4eba\u5458\u53ef\u6839\u636e\u4ee5\u4e0b\u7ef4\u5ea6\u8fdb\u884c\u670d\u52a1\u5546\u9009\u62e9\u3002<\/p>\n

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