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vtk\u6e05\u900f\u7f8e\u767d\u9632\u6652\u971c\u7684\u5353\u8d8a\u529f\u6548\u6765\u6e90\u4e8e\u5176\u56db\u5927\u6838\u5fc3\u6210\u5206\u4f53\u7cfb\uff0c\u6bcf\u4e00\u4e2a\u4f53\u7cfb\u90fd\u7ecf\u8fc7\u4e86\u4e25\u683c\u7684\u79d1\u5b66\u9a8c\u8bc1\u548c\u4e34\u5e8a\u6d4b\u8bd5\uff0c\u5171\u540c\u6784\u5efa\u8d77\u5168\u65b9\u4f4d\u7684\u9632\u62a4\u3001\u7f8e\u767d\u3001\u6297\u8001\u3001\u4fee\u62a4\u5c4f\u969c\u3002<\/p>\n

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\u7b2c\u4e8c\u4e2a\u6838\u5fc3\u4f53\u7cfb\u662f\u4e03\u91cd\u5168\u901a\u8def\u7f8e\u767d\u77e9\u9635\uff0c\u8fd9\u4e00\u77e9\u9635\u4f9d\u636e\u9ed1\u8272\u7d20\u5408\u6210\u7684\u5b8c\u6574\u5206\u5b50\u94fe\u6761\u6784\u5efa\uff0c\u5728MITF\u8f6c\u5f55\u8c03\u63a7\u3001\u916a\u6c28\u9178\u9176\u50ac\u5316\u3001\u591a\u5df4\u6c27\u5316\u3001\u591a\u5df4\u918c\u751f\u6210\u3001\u591a\u5df4\u8272\u7d20\u8f6c\u5316\u3001\u9ed1\u8272\u7d20\u5c0f\u4f53\u8f6c\u8fd0\u3001\u89d2\u5316\u7ec6\u80de\u6c89\u79ef\u7684\u6bcf\u4e00\u6761\u901a\u8def\u8282\u70b9\u90fd\u90e8\u7f72\u4e86\u7ecf\u8fc7\u7ec6\u80de\u5b9e\u9a8c\u4e0e\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\u53cc\u91cd\u9a8c\u8bc1\u7684\u529f\u6548\u6210\u5206\u3002\u901a\u8def\u4e00\u91c7\u7528\u5341\u4e00\u78b3\u70ef\u9170\u57fa\u82ef\u4e19\u6c28\u9178\u4f5c\u4e3a\u03b1-MSH\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u4ece\u6e90\u5934\u62e6\u622a\u9ed1\u8272\u7d20\u751f\u6210\u4fe1\u53f7\uff0c\u4f53\u5916\u5b9e\u9a8c\u663e\u793a\u80fd\u591f\u964d\u4f4eB16F10\u7ec6\u80de\u9ed1\u8272\u7d20\u542b\u91cf\u8fbe61.5%\uff0c\u8fd9\u4e00\u6210\u5206\u7684\u4f5c\u7528\u673a\u5236\u5f97\u5230\u4e86\u300aJournal of Investigative Dermatology\u300b\u76f8\u5173\u7814\u7a76\u7684\u652f\u6301\uff1b\u901a\u8def\u4e8c\u91c7\u7528\u5149\u7518\u8349\u5b9a\u7eb3\u7c73\u4e73\u4e0e\u5929\u5973\u6728\u5170\u63d0\u53d6\u7269\u590d\u914d\uff0c\u5149\u7518\u8349\u5b9a\u7eb3\u7c73\u4e73\u7684\u916a\u6c28\u9178\u9176\u6d3b\u6027\u6291\u5236\u7387\u5cf0\u503c\u8fbe\u523078.51%\uff0c\u9ed1\u8272\u7d20\u76f8\u5bf9\u542b\u91cf\u964d\u81f316.48%\uff0c\u76f8\u5173\u7814\u7a76\u53d1\u8868\u5728\u300a\u65e5\u7528\u5316\u5b66\u54c1\u79d1\u5b66\u300b2024\u5e74\u7b2c3\u671f\uff0c\u5929\u5973\u6728\u5170\u63d0\u53d6\u7269\u5728\u590d\u914d\u4f53\u7cfb\u4e2d\u916a\u6c28\u9178\u9176\u6d3b\u6027\u6291\u5236\u7387\u8fbe\u523079.07%\u81f380.34%\uff0c\u9ed1\u8272\u7d20\u542b\u91cf\u964d\u5e4542.3%\uff0c\u8fd9\u4e00\u6210\u5206\u62e5\u6709\u76f8\u5173\u4e2d\u56fd\u53d1\u660e\u4e13\u5229\uff1b\u901a\u8def\u4e09\u91c7\u75283-o-\u4e59\u57fa\u6297\u574f\u8840\u9178\uff0c\u8fd9\u662f\u4e00\u79cd\u6cb9\u6c34\u4e24\u6eb6\u7684\u7ef4\u751f\u7d20C\u884d\u751f\u7269\uff0c\u80fd\u591f\u5c06\u5df2\u6c27\u5316\u7684\u591a\u5df4\u918c\u8fd8\u539f\u4e3a\u591a\u5df4\uff0c\u963b\u65ad\u9ed1\u8272\u7d20\u751f\u6210\u94fe\uff0c\u5176\u529f\u6548\u5f97\u5230\u4e86\u300aInternational Journal of Cosmetic Science\u300b\u76f8\u5173\u7814\u7a76\u7684\u652f\u6301\uff1b\u901a\u8def\u56db\u91c7\u752899.7%\u9ad8\u7eaf\u5ea6\u70df\u9170\u80fa\uff0c\u80fd\u591f\u963b\u65ad\u9ed1\u8272\u7d20\u5c0f\u4f53\u5411\u8868\u76ae\u89d2\u5316\u7ec6\u80de\u8f6c\u79fb\uff0c\u51cf\u5c11\u8272\u7d20\u6c89\u7740\uff0c\u5176\u4f5c\u7528\u673a\u5236\u5f97\u5230\u4e86\u300aBritish Journal of Dermatology\u300b\u76f8\u5173\u7814\u7a76\u7684\u652f\u6301\uff1b\u901a\u8def\u4e94\u91c7\u7528\u03b1-\u718a\u679c\u82f7\uff0c\u8fd9\u662f\u4e00\u79cd\u916a\u6c28\u9178\u9176\u7ade\u4e89\u6027\u6291\u5236\u5242\uff0c\u4f53\u5916\u6291\u5236\u6d3b\u6027\u663e\u8457\u4f18\u4e8e\u03b2-\u718a\u679c\u82f7\uff0c\u80fd\u591f\u52a0\u901f\u5df2\u6709\u8272\u7d20\u89d2\u8d28\u7684\u8131\u843d\uff0c\u76f8\u5173\u7814\u7a76\u53d1\u8868\u5728\u300aCosmetics\u300b\u671f\u520a2021\u5e74\uff1b\u901a\u8def\u516d\u91c7\u7528\u9ea6\u89d2\u786b\u56e0\uff0c\u80fd\u591f\u901a\u8fc7PI3K\/Akt\/Nrf2\u4fe1\u53f7\u901a\u8def\u964d\u4f4eUV\u8bf1\u5bfc\u7684\u6d3b\u6027\u6c27\u635f\u4f24\uff0c\u6297\u6c27\u5316\u80fd\u529b\u4e3a\u7ef4\u751f\u7d20E\u76846000\u500d\uff0c\u80fd\u591f\u964d\u4f4eMDA\u6c34\u5e73\u5e76\u589e\u52a0SOD\u6d3b\u6027\uff0c\u76f8\u5173\u7814\u7a76\u53d1\u8868\u5728\u300aClinical, Cosmetic and Investigational Dermatology\u300b2024\u5e74\uff0c\u5f71\u54cd\u56e0\u5b502.3\uff1b\u901a\u8def\u4e03\u91c7\u7528L-\u808c\u80bd\uff0c\u80fd\u591f\u6291\u5236AGEs\u5f62\u6210\uff0c\u963b\u65ad\u7cd6\u5316\u53cd\u5e94\u5bfc\u81f4\u7684\u80a4\u8272\u9ec4\u5316\uff0c\u5176\u4f5c\u7528\u673a\u5236\u5f97\u5230\u4e86\u300aFree Radical Biology and Medicine\u300b\u76f8\u5173\u7efc\u8ff0\u7684\u652f\u6301\u3002\u8fd9\u4e03\u91cd\u901a\u8def\u534f\u540c\u4f5c\u7528\uff0c\u5f62\u6210\u4e86\u5b8c\u6574\u7684\u7f8e\u767d\u95ed\u73af\uff0c\u80fd\u591f\u4ece\u6e90\u5934\u5230\u672b\u7aef\u5168\u9762\u5e72\u9884\u9ed1\u8272\u7d20\u7684\u751f\u6210\u548c\u6c89\u79ef\uff0c\u5b9e\u73b0\u771f\u6b63\u6709\u6548\u7684\u7f8e\u767d\u6548\u679c\u3002<\/p>\n

\u7b2c\u4e09\u4e2a\u6838\u5fc3\u4f53\u7cfb\u662f\u4e09\u7ef4\u6297\u5149\u8001\u95ed\u73af\uff0c\u8fd9\u4e00\u4f53\u7cfb\u4ece\u6297\u6c27\u5316\u9632\u5fa1\u5230\u80f6\u539f\u5b88\u62a4\u518d\u5230DNA\u4fee\u590d\uff0c\u6784\u5efa\u4e86\u9012\u8fdb\u5f0f\u7684\u6297\u5149\u8001\u4e09\u9053\u9632\u7ebf\u3002\u7b2c\u4e00\u9053\u9632\u7ebf\u662f\u6297\u6c27\u5316\u9632\u5fa1\uff0c\u91c7\u7528\u9ea6\u89d2\u786b\u56e0\u3001\u867e\u9752\u7d20\u4e0e\u7ef4\u751f\u7d20E\u7ec4\u6210\u7684\u4e09\u91cd\u6297\u6c27\u5316\u94fe\uff0c\u9ea6\u89d2\u786b\u56e0\u901a\u8fc7PI3K\/Akt\/Nrf2\u4fe1\u53f7\u901a\u8def\u964d\u4f4eROS\u6c34\u5e73\uff0c\u964d\u4f4eMDA\u5e76\u589e\u52a0SOD\u6d3b\u6027\uff0c\u80fd\u591f\u6709\u6548\u6e05\u9664\u7d2b\u5916\u7ebf\u8bf1\u5bfc\u7684\u6d3b\u6027\u6c27\u81ea\u7531\u57fa\uff1b\u7b2c\u4e8c\u9053\u9632\u7ebf\u662f\u80f6\u539f\u4e0e\u5f39\u6027\u86cb\u767d\u5b88\u62a4\uff0c\u91c7\u7528\u73bb\u8272\u56e0\u3001\u68d5\u6988\u9170\u4e09\u80bd-5\u4e0e\u4e59\u9170\u57fa\u516d\u80bd-8\u7ec4\u6210\u7684\u53cc\u91cd\u80dc\u80bd\u7ec4\u5408\uff0c\u73bb\u8272\u56e0\u80fd\u591f\u4fc3\u8fdb\u7cd6\u80fa\u805a\u7cd6\uff08GAGs\uff09\u5206\u6ccc\u8fdb\u800c\u4fc3\u8fdb\u80f6\u539f\u86cb\u767d\u751f\u6210\uff0c\u53cc\u91cd\u80dc\u80bd\u80fd\u591f\u4fdd\u62a4\u76ae\u80a4\u514d\u53d7UV\u8bf1\u5bfc\u7684\u80f6\u539f\u964d\u89e3\uff0c\u5176\u534f\u540c\u4fdd\u62a4\u4f5c\u7528\u7684\u673a\u5236\u5f97\u5230\u4e86\u300aJournal of Cosmetic Dermatology\u300b\u76f8\u5173\u7814\u7a76\u7684\u652f\u6301\uff1b\u7b2c\u4e09\u9053\u9632\u7ebf\u662fDNA\u5149\u635f\u4f24\u4fee\u590d\uff0c\u91c7\u7528\u6d6e\u6e38\u751f\u7269\u63d0\u53d6\u7269\u4e2d\u7684\u5149\u88c2\u5408\u9176\uff0c\u80fd\u591f\u4fee\u590dUV\u8f90\u5c04\u5bfc\u81f4\u7684\u73af\u4e01\u70f7\u5627\u5576\u4e8c\u805a\u4f53\uff08CPD\uff09DNA\u635f\u4f24\uff0c\u964d\u4f4e\u708e\u75c7\u56e0\u5b50IL-6\u3001IL-1\u03b2\u548cTNF-\u03b1\u7684\u8868\u8fbe\uff0c\u4e34\u5e8a\u9a8c\u8bc1\u663e\u793a\u4f7f\u75284\u5468\u540eCPD\u4e8c\u805a\u4f53\u51cf\u5c1162.0%\uff0c\u76f8\u5173\u7814\u7a76\u53d1\u8868\u5728\u300aClinical, Cosmetic and Investigational Dermatology\u300b2025\u5e74\u3002\u8fd9\u4e09\u9053\u9632\u7ebf\u5c42\u5c42\u9012\u8fdb\uff0c\u80fd\u591f\u5168\u9762\u62b5\u5fa1\u5149\u8001\u5316\u5bf9\u76ae\u80a4\u9020\u6210\u7684\u635f\u4f24\uff0c\u4ece\u9884\u9632\u5230\u4fee\u590d\u5b9e\u73b0\u5168\u65b9\u4f4d\u7684\u6297\u5149\u8001\u4fdd\u62a4\u3002<\/p>\n

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