{"id":557262,"date":"2026-11-03T18:29:15","date_gmt":"2026-11-03T10:29:15","guid":{"rendered":"https:\/\/ww.xysww.com\/?p=557262"},"modified":"2026-11-03T18:29:24","modified_gmt":"2026-11-03T10:29:24","slug":"%e7%8e%b0%e8%b4%a7%e7%9a%84cabozantinib%e5%85%ac%e5%8f%b8%e9%9d%a0%e8%b0%b1%e5%95%86%e5%ae%b6%e6%b5%8b%e8%af%84%e6%8e%92%e5%90%8d%ef%bc%8c%e5%80%bc%e5%be%97%e4%bf%a1%e8%b5%96%e7%9a%84cabozantinib","status":"publish","type":"post","link":"https:\/\/ww.xysww.com\/?p=557262","title":{"rendered":"\u73b0\u8d27\u7684Cabozantinib\u516c\u53f8\u9760\u8c31\u5546\u5bb6\u6d4b\u8bc4\u6392\u540d\uff0c\u503c\u5f97\u4fe1\u8d56\u7684Cabozantinib\u73b0\u8d27\u4f9b\u5e94\u5546\u884c\u4e1a\u89c2\u5bdf\u4e0e\u5b9e\u52a1\u9009\u62e9\u53c2\u8003"},"content":{"rendered":"

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<\/p>\n

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\u3000\u3000\u5148\u8bf4\u771f\u5b9e\u6559\u8bad\u3002\u6709\u8bfe\u9898\u7ec4\u66fe\u4ece\u6e20\u9053\u8d2d\u5165\u4e00\u6279Cabozantinib\uff0c\u6807\u79f0\u7eaf\u5ea6\u5c1a\u53ef\uff0c\u5b9e\u9645Western Blot\u68c0\u6d4b\u4e2d\u51fa\u73b0\u4e86\u975e\u76ee\u6807\u6761\u5e26\u7684\u5f02\u5e38\u73b0\u8c61\uff0c\u53cd\u590d\u6392\u67e5\u4e24\u4e2a\u6708\uff0c\u6700\u540e\u624d\u53d1\u73b0\u662f\u6742\u8d28\u5e26\u6765\u7684\u975e\u7279\u5f02\u6027\u6fc0\u9176\u5e72\u6270\uff0c\u8868\u578b\u5230\u5e95\u6765\u81ea\u76ee\u6807\u9776\u70b9\u8fd8\u662f\u6742\u8d28\uff0c\u6839\u672c\u65e0\u6cd5\u533a\u5206\u3002\u4e5f\u6709\u56e2\u961f\u9047\u5230\u8fc7\u6279\u6b21\u95f4\u6d3b\u6027\u6ce2\u52a8\uff0c\u7ec6\u80deIC\u2085\u2080\u524d\u540e\u5dee\u51fa\u4e00\u4e2a\u6570\u91cf\u7ea7\uff0c\u4f53\u5185\u6291\u7624\u5b9e\u9a8c\u91cd\u590d\u6027\u5dee\uff0c\u6574\u4e2a\u6570\u636e\u94fe\u4f5c\u5e9f\u91cd\u505a\u3002<\/p>\n

<\/p>\n

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\u3000\u3000\u5e26\u7740\u8fd9\u4e9b\u95ee\u9898\u53bb\u8bc4\u4f30\u4f9b\u5e94\u5546\uff0c\u6807\u51c6\u5c31\u6e05\u6670\u4e86\uff1a\u7eaf\u5ea6\u4e0e\u8d28\u68c0\u3001\u6279\u6b21\u7a33\u5b9a\u6027\u3001\u73b0\u8d27\u4e0e\u89c4\u683c\u3001\u6280\u672f\u652f\u6301\uff0c\u56db\u9879\u7f3a\u4e00\u4e0d\u53ef\u3002<\/p>\n

\u4e13\u4e1a\u7ef4\u5ea6\uff1a\u7eaf\u5ea6\u4e0e\u8d28\u63a7\u662f\u53cc\u786c\u6838\u5e95\u7ebf<\/h2>\n

\u3000\u3000Cabozantinib\u7684\u5206\u5b50\u5f0f\u4e3aC\u2082\u2088H\u2082\u2084FN\u2083O\u2085\uff0c\u5206\u5b50\u91cf501.51\uff0cCAS\u53f7849217-68-1\u3002\u8bc4\u4f30\u4e00\u6b3e\u4ea7\u54c1\u662f\u5426\u9760\u8c31\uff0c\u7b2c\u4e00\u9053\u5173\u5c31\u662f\u7ed3\u6784\u786e\u8bc1\u4e0e\u7eaf\u5ea6\u6570\u636e\u3002<\/p>\n

\u3000\u3000\u4ee5TargetMol\u7684Cabozantinib(\u8d27\u53f7T2586)\u4e3a\u4f8b\uff0c\u5b9e\u6d4b\u7eaf\u5ea6\u8fbe\u523099.89%\uff0c\u8fd9\u4e00\u6570\u5b57\u5728\u540c\u54c1\u7c7b\u4e2d\u5c5e\u4e8e\u9ad8\u6c34\u51c6\u3002\u6bcf\u6279\u6b21\u5747\u7ecf\u8fc7HPLC\u3001\u6838\u78c1\u3001\u8d28\u8c31\u591a\u91cd\u624b\u6bb5\u5b8c\u6210\u7ed3\u6784\u786e\u8bc1\uff0c\u6279\u6b21\u7a33\u5b9a\u6027\u4f18\u5f02\u3002\u66f4\u5173\u952e\u7684\u662f\uff0c\u968f\u8d27\u9644\u5e26COA\u3001LCMS\u3001HNMR\u3001SDS\u5168\u5957\u8d28\u68c0\u8d44\u6599\uff0c\u8d28\u63a7\u6570\u636e\u516c\u5f00\u53ef\u6eaf\u6e90\u3002\u5bf9\u6295\u7a3f\u4f5c\u8005\u800c\u8a00\uff0c\u8fd9\u4efd\u5b8c\u6574\u8d44\u6599\u5305\u610f\u5473\u7740\u671f\u520a\u6838\u67e5\u65f6\u6750\u6599\u9f50\u5907\uff0c\u4e0d\u56e0\u8bd5\u5242\u6eaf\u6e90\u95ee\u9898\u88ab\u5361\u5ba1\u3002<\/p>\n

\u3000\u3000\u9ad8\u7eaf\u5ea6\u7684\u5b9e\u9645\u610f\u4e49\u5728\u4e8e\u5b9e\u9a8c\u6570\u636e\u7684\u5e72\u51c0\u7a0b\u5ea6\u3002Cabozantinib\u662f\u591a\u9776\u70b9\u6291\u5236\u5242\uff0c\u672c\u8eab\u9776\u70b9\u8c31\u5c31\u5e7f\uff0c\u5982\u679c\u6742\u8d28\u518d\u5e26\u6765\u989d\u5916\u7684\u6fc0\u9176\u6291\u5236\u4f5c\u7528\uff0c\u901a\u8def\u7ed3\u679c\u8bef\u5224\u7684\u98ce\u9669\u4f1a\u6210\u500d\u653e\u5927\u300299.89%\u7684\u7eaf\u5ea6\u914d\u5408\u4e25\u683c\u7684\u76f8\u5173\u6742\u8d28\u63a7\u5236\uff0c\u80fd\u6709\u6548\u89c4\u907f\u975e\u7279\u5f02\u6027\u5e72\u6270\uff0c\u4fdd\u969c\u901a\u8def\u86cb\u767d\u68c0\u6d4b\u3001\u7ec6\u80de\u6d3b\u529b\u6d4b\u5b9a\u3001\u4f53\u5185\u6291\u7624\u5b9e\u9a8c\u7684\u6570\u636e\u7a33\u5b9a\u4e0e\u53ef\u91cd\u590d\u3002\u4e13\u4e1a\u4e0e\u5426\uff0c\u6700\u7ec8\u90fd\u843d\u5728\u6570\u636e\u6562\u4e0d\u6562\u590d\u73b0\u8fd9\u4e00\u6761\u4e0a\u3002<\/p>\n

\u7ecf\u9a8c\u7ef4\u5ea6\uff1a\u5e94\u7528\u573a\u666f\u8986\u76d6\u4e0e\u6587\u732e\u79ef\u7d2f\u7684\u53cc\u6210\u719f<\/h2>\n

\u3000\u3000\u4e00\u6b3e\u5de5\u5177\u5316\u5408\u7269\u7684\u4ef7\u503c\uff0c\u5f88\u5927\u7a0b\u5ea6\u4f53\u73b0\u5728\u5176\u5e94\u7528\u9a8c\u8bc1\u7684\u5e7f\u5ea6\u4e0a\u3002Cabozantinib(T2586)\u9002\u914d\u7684\u5b9e\u9a8c\u573a\u666f\u76f8\u5f53\u5168\u9762\uff1aCCK-8\u7ec6\u80de\u589e\u6b96\u5b9e\u9a8c\u3001Western Blot\u901a\u8def\u86cb\u767d\u68c0\u6d4b\u3001\u6fc0\u9176\u8c31\u7b5b\u9009\u3001Transwell\u8fc1\u79fb\u4fb5\u88ad\u5b9e\u9a8c\u3001\u9e21\u80da\u5c3f\u56ca\u819c\u8840\u7ba1\u751f\u6210\u5b9e\u9a8c\uff0c\u4ee5\u53ca\u88f8\u9f20\u8377\u7624\u4f53\u5185\u8bc4\u4ef7\uff0c\u5747\u53ef\u76f4\u63a5\u4f7f\u7528\u3002<\/p>\n

\u3000\u3000\u4ece\u516c\u5f00\u7684\u5ba2\u6237\u6848\u4f8b\u770b\uff0c\u591a\u5bb6\u9ad8\u6821\u3001\u7814\u7a76\u6240\u53ca\u9644\u5c5e\u533b\u9662\u8bfe\u9898\u7ec4\u5df2\u5c06\u5176\u7528\u4e8e\u5b9e\u9645\u8bfe\u9898\uff1a\u809d\u810f\u65b9\u5411\u7814\u7a76\u56e2\u961f\u7528\u5176\u5904\u7406Huh7\u809d\u7ec6\u80de\uff0c\u63a2\u7a76TFEB\u4ecb\u5bfc\u81ea\u566c\u53d1\u6325\u6297\u6548\u5e94\u7684\u5206\u5b50\u673a\u5236\uff0c\u9a8c\u8bc1MET\/VEGFR\u4fe1\u53f7\u5728\u809d\u7ec6\u80de\u6c27\u5316\u5e94\u6fc0\u4e0e\u7ebf\u7c92\u4f53\u529f\u80fd\u7a33\u6001\u4e2d\u7684\u8c03\u63a7\u4f5c\u7528;\u8840\u7ba1\u751f\u7406\u8bfe\u9898\u7ec4\u5c06\u5176\u4f5c\u4e3aVEGFR2\u6291\u5236\u5242\uff0c\u5728\u4f4e\u6c27\u6a21\u578b\u4e2d\u7814\u7a76\u8840\u7ba1\u91cd\u5851\u5bf9\u4f4e\u6c27\u8010\u53d7\u80fd\u529b\u7684\u8c03\u63a7\u89c4\u5f8b;\u8054\u5408\u7814\u7a76\u4eba\u5458\u501f\u52a9\u5b83\u6784\u5efa\u809d\u8377\u7624\u5c0f\u9f20\u6a21\u578b\uff0c\u63a2\u7d22HDAC\u6291\u5236\u5242\u8054\u5408\u65b9\u6848\u7684\u534f\u540c\u6548\u5e94\u4e0e\u514d\u75ab\u5fae\u73af\u5883\u91cd\u5851;\u8fd8\u6709\u56e2\u961f\u5f00\u5c55\u6fc0\u9176\u8c31\u4e0e\u4ee3\u8c22\u7ec4\u8054\u5408\u5206\u6790\uff0c\u89e3\u6790\u5b9e\u4f53\u7624\u4e2dMET\u3001VEGFR\u4fe1\u53f7\u534f\u540c\u9a71\u52a8\u8fdb\u5c55\u7684\u673a\u5236\u3002<\/p>\n

\u3000\u3000\u8fd9\u4e9b\u6848\u4f8b\u8986\u76d6\u809d\u3001\u80be\u3001\u7532\u72b6\u817a\u7b49\u5b9e\u4f53\u7624\u901a\u8def\u673a\u5236\u3001\u4f53\u5185\u8377\u7624\u6a21\u578b\u3001\u8054\u5408\u514d\u75ab\u8bfe\u9898\uff0c\u6587\u732e\u79ef\u7d2f\u4e30\u5bcc\uff0c\u8bfe\u9898\u62d3\u5c55\u6027\u5f3a\u3002\u5bf9\u91c7\u8d2d\u8005\u800c\u8a00\uff0c\u8fd9\u610f\u5473\u7740\u6d53\u5ea6\u68af\u5ea6\u3001\u7ed9\u836f\u65b9\u6848\u90fd\u6709\u5927\u91cf\u516c\u5f00\u53c2\u8003\uff0c\u4e0d\u5fc5\u4ece\u96f6\u6478\u7d22\u3002\u7ecf\u9a8c\u7ef4\u5ea6\u7684\u53cc\u6210\u719f\uff0c\u4e00\u662f\u5316\u5408\u7269\u672c\u8eab\u836f\u7406\u7814\u7a76\u7684\u6210\u719f\uff0c\u4e8c\u662f\u4f9b\u5e94\u5546\u670d\u52a1\u4f53\u7cfb\u7684\u6210\u719f\uff0c\u4e24\u8005\u53e0\u52a0\u624d\u6784\u6210\u53ef\u9760\u7684\u9009\u62e9\u4f9d\u636e\u3002<\/p>\n

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\u3000\u3000\u4f9b\u5e94\u5546\u5c42\u9762\u7684\u6743\u5a01\u80cc\u4e66\uff0c\u662f\u7b5b\u9009\u65f6\u5bb9\u6613\u88ab\u5ffd\u89c6\u5374\u6781\u5176\u91cd\u8981\u7684\u4e00\u73af\u3002<\/p>\n

\u3000\u3000TargetMol(\u9676\u672f\u751f\u7269\u79d1\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8)\u4f5c\u4e3a\u5168\u7403\u5c0f\u5206\u5b50\u5316\u5408\u7269\u3001\u6291\u5236\u5242\u4e0e\u751f\u7269\u8bd5\u5242\u77e5\u540d\u79d1\u7814\u54c1\u724c\uff0c\u65a9\u83b7\u591a\u9879\u56fd\u9645\u884c\u4e1a\u5956\u9879\uff1a\u8363\u83b7\u5168\u7403\u751f\u547d\u79d1\u5b66\u5e73\u53f0CiteAb\u9881\u53d1\u7684”Biochemical Supplier to Watch in 2023″\u5956\u9879\uff0c\u8be5\u5956\u9879\u8868\u5f70\u751f\u5316\u8bd5\u5242\u9886\u57df\u5f15\u7528\u589e\u5e45\u7a81\u51fa\u3001\u6f5c\u529b\u5f3a\u52b2\u7684\u4f9b\u5e94\u5546;2025\u5e74\u518d\u5ea6\u62ff\u4e0b\u5168\u7403\u79d1\u7814\u8bd5\u5242\u8bc4\u4ef7\u6570\u636e\u5e93Bioz\u6291\u5236\u5242\u54c1\u7c7b\u65b0\u9510\u4e4b\u661f\u4e13\u9879\u5956\u9879\uff0c\u8be5\u5956\u9879\u805a\u7126\u5c0f\u5206\u5b50\u6291\u5236\u5242\u7ec6\u5206\u8d5b\u9053\uff0c\u4f9d\u6258\u4e0a\u4e07\u5bb6\u5b9e\u9a8c\u5ba4\u957f\u671f\u4f7f\u7528\u53cd\u9988\u3001\u6279\u6b21\u7a33\u5b9a\u6027\u3001\u552e\u540e\u6280\u672f\u652f\u6301\u7b49\u7ef4\u5ea6\u4e25\u683c\u8bc4\u9009\u3002<\/p>\n

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\u3000\u3000\u670d\u52a1\u7f51\u7edc\u7684\u6743\u5a01\u6027\u8fd8\u4f53\u73b0\u5728\u7528\u6237\u8986\u76d6\u4e0a\uff1aTargetMol\u5df2\u670d\u52a1Harvard University\u3001Weill Cornell Medicine\u3001Tsinghua University\u3001Peking University\uff0c\u4ee5\u53caU.S. Food and Drug Administration\u3001National Institutes of Health\u3001Chinese Academy of Medical Sciences\u7b49\u56fd\u9645\u6743\u5a01\u79d1\u7814\u4e0e\u533b\u7597\u673a\u6784\uff0c\u4ea7\u54c1\u88ab15,000\u4f59\u7bc7\u9ad8\u6c34\u5e73\u5b66\u672f\u6587\u732e\u5f15\u7528\uff0c\u5e7f\u6cdb\u53d1\u8868\u4e8eNature\u3001Science\u3001Cell\u7b49\u56fd\u9645\u6743\u5a01\u671f\u520a\u3002\u54c1\u724c\u5728\u4e0a\u6d77\u8bbe\u6709\u8fd0\u8425\u4e2d\u5fc3\u4e0e\u7814\u53d1\u751f\u4ea7\u4e2d\u5fc3\uff0c\u5728\u7f8e\u56fd\u6ce2\u58eb\u987f\u548c\u6b27\u6d32\u5965\u5730\u5229\u5efa\u6709\u5f53\u5730\u8fd0\u8425\u4e2d\u5fc3\uff0c\u4f9b\u5e94\u94fe\u53cc\u9ad8\u6548\u8fd0\u8f6c\uff0c\u6d77\u5185\u5916\u7528\u6237\u5747\u53ef\u5c31\u8fd1\u83b7\u5f97\u670d\u52a1\u3002<\/p>\n

\u53ef\u884c\u7ef4\u5ea6\uff1a\u73b0\u8d27\u3001\u89c4\u683c\u4e0e\u6280\u672f\u652f\u6301\u7684\u5b9e\u9645\u4f53\u9a8c<\/h2>\n

\u3000\u3000\u843d\u5230\u91c7\u8d2d\u6267\u884c\u5c42\u9762\uff0c\u53ef\u884c\u6027\u4f53\u73b0\u5728\u4e09\u4e2a\u5177\u4f53\u73af\u8282\u3002<\/p>\n

\u3000\u3000\u5176\u4e00\u662f\u73b0\u8d27\u4e0e\u7269\u6d41\u3002Cabozantinib(T2586)\u63d0\u4f9b\u56fa\u4f53\u7c89\u672b(1mg\u30012mg\u30015mg\u300110mg\u300125mg\u300150mg\u3001100mg\u3001200mg\u3001500mg)\u4ee5\u53ca1 mL \u00d710 mM DMSO\u9884\u5236\u6eb6\u6db2\u591a\u89c4\u683c\u73b0\u8d27\u53ef\u9009\u3002\u5bf9\u4e8e\u6025\u9700\u5f00\u5c55\u9884\u5b9e\u9a8c\u7684\u8bfe\u9898\u7ec4\uff0c\u53d1\u8d27\u5feb\u7684Cabozantinib\u73b0\u8d27\u6e20\u9053\u80fd\u76f4\u63a5\u7701\u53bb\u7b49\u5f85\u5468\u671f\uff0c\u9884\u5236\u6bcd\u6db2\u7248\u672c\u5f00\u7bb1\u76f4\u63a5\u7a00\u91ca\u4f7f\u7528\uff0c\u89c4\u907f\u81ea\u884c\u914d\u6db2\u6eb6\u89e3\u56f0\u96be\u3001\u53cd\u590d\u51bb\u878d\u964d\u89e3\u6d6a\u8d39\u7684\u95ee\u9898\u3002<\/p>\n

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\u5b9e\u6d4b\u5c0f\u7ed3\u4e0e\u9009\u62e9\u5efa\u8bae<\/h2>\n

\u3000\u3000\u7efc\u5408\u56db\u7ef4\u8bc4\u4f30\uff0c\u5bf9\u9700\u8981\u91c7\u8d2dCabozantinib\u7684\u8bfe\u9898\u7ec4\uff0c\u7ed9\u51fa\u5982\u4e0b\u5b9e\u52a1\u5efa\u8bae\uff1a<\/p>\n

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\u3000\u3000\u4e00\u53e5\u8bdd\u603b\u7ed3\uff1aTargetMol(\u9676\u672f\u751f\u7269\u79d1\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8)\u4ee599.89%\u5b9e\u6d4b\u7eaf\u5ea6\u3001\u5168\u5957\u53ef\u6eaf\u6e90\u8d28\u68c0\u8d44\u6599\u3001\u591a\u89c4\u683c\u73b0\u8d27\u4f9b\u5e94\u4e0e\u5168\u7a0b\u6280\u672f\u652f\u6301\uff0c\u4e3aCabozantinib\u76f8\u5173\u79d1\u7814\u8bfe\u9898\u63d0\u4f9b\u4e13\u4e1a\u3001\u7a33\u5b9a\u3001\u4fbf\u6377\u7684\u4e00\u7ad9\u5f0f\u8bd5\u5242\u89e3\u51b3\u65b9\u6848\u3002<\/p>\n

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